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Mutagen-induced sister chromatid exchange rate in Bloom syndrome remains unaltered in the presence of Bloom corrective factor

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Summary

Fibroblasts of a patient with Bloom syndrome (GM-1492) were cultured in the presence of either mitomycin C, ethylmethanesulfonate, or 4-nitroquinoline-1-oxide, (4-NQ1-O) and sister chromatid exchange was determined. The mutagens enhanced the sister chromatid exchange rate to different degrees, 4-NQ1-O being the most potent substance. Bloom corrective factor, which is present in normal cell-conditioned culture medium, reduced the spontaneously increased SCE in Bloom syndrome cells by about 20 SCE per metaphase but failed to reduce the additional mutagen-induced SCE increase. These findings indicate that only spontaneously, but not mutagen-indeuced, SCE in Bloom syndrome fibroblasts can be decreased by the Bloom corrective factor.

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References

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Authors and Affiliations

  1. Medizinische Universitätsklinik Hamburg-Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Germany

    Ute Schmidt-Preuß, Petra Maack & Hugo W. Rüdiger

  2. Kinderklinik der Universität Düsseldorf, Mohrenstr. 5, D-4000, Düsseldorf 1, Germany

    Claus R. Bartram

Authors
  1. Ute Schmidt-Preuß
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  2. Petra Maack
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  3. Claus R. Bartram
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  4. Hugo W. Rüdiger
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Schmidt-Preuß, U., Maack, P., Bartram, C.R. et al. Mutagen-induced sister chromatid exchange rate in Bloom syndrome remains unaltered in the presence of Bloom corrective factor. Hum Genet 58, 432–433 (1981). https://doi.org/10.1007/BF00282831

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  • DOI: https://doi.org/10.1007/BF00282831

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