Skip to main content
SpringerLink
Log in

Linkage group HL-A-MLC-Bf (properdin factor B)

The site of the Bf locus at the immunogenetic linkage group on chromosome 6

  • Original Investigations
  • Published:
Humangenetik Aims and scope Submit manuscript

Summary

Genetic linkage between the HL-A and Bf loci could be confirmed in 43 families with 168 offspring. In 4 families, 5 recombinants out of 82 informative meiotic divisions were observed (r=6.1%). The localisation of the Bf marker system was studied in 3 families with crossovers between HL-A and MLC. From these data the following map order of human chromosome 6 can be proposed: HL-A (1st locus) —HL-A (2nd locus)—MLC-Bf---PGM3. The fact that important components of the classical and alternate pathway of complement activation are governed by genes closely linked with HL-A and MLC loci leads to the proposition to include the Bf system into the Major Histocompatibility Complex in man.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Agnello, V., de Bracco, M. M. E., Kunkel, H. G.: Hereditary C2 deficiency with some manifestations of systemic lupus erythematosus. J. Immunol. 106, 837–840 (1973)

    Google Scholar 

  • Albert, E. D., Mickey, M. R., Ting, A., Terasaki, P. I.: Deduction of 2140 HL-A haplotypes and segregation analysis in 535 families. Transplant. Proc.5, 215–221 (1973)

    Google Scholar 

  • Allen, F. H., Jr.: Linkage of HL-A and GBG. Vox Sang.(Basel) 27, 382–384 (1974)

    Google Scholar 

  • Alper, C. A., Boenisch, T., Watson, L.: Glycine-rich β-glycoprotein (GBG): Evidence for relation to the complement system and for genetic polymorphism in man. J.Immunol. 107, 323 (1971) (Abstr.)

    Google Scholar 

  • Alper, C. A., Boenisch, T., Watson, L.: Genetic polymorphism in human glycine-rich β-glycoprotein. J. exp. Med. 135, 68–80 (1972)

    Google Scholar 

  • Alper, C. A., Johnson, A. M.: Immunofixation electrophoresis: a technique for the study of protein polymorphism. Vox Sang. (Basel) 17, 445–452 (1969)

    Google Scholar 

  • Amos, D. B., Bach, F. H.: Phenotypic expression of the major histocompatbility locus in man (HL-A): Leukocyte antigens and a mixed leukocyte culture reactivity. J. exp. Med. 128, 623–627 (1968)

    Google Scholar 

  • Blum, L., Pillemer, L., Lepow, J. H.: The properdin system and immunity. XIII: Assay and properties of a heat-labile serum factor (factor B) in the properdin system. Z. Immun.-Forsch. 118, 350–356 (1959)

    Google Scholar 

  • Bodmer, W. F.: Population genetics of the HL-A system: retrospect and prospect. Histocompatibility Testing 1972, pp. 611–617. Copenhagen: Munksgaard 1973

    Google Scholar 

  • Boenisch, T., Alper, C. A.: Isolation and properties of a glycine-rich β-glycoprotein of human serum. Biochim. biophys. Acta (Amst.) 221, 529–532 (1970)

    Google Scholar 

  • Capová, J., Démant, P.: Genetic studies of the H-2-associated complement gene. Folia biol. (Prague) 20, 101–115 (1974)

    Google Scholar 

  • Démant, P., Capková, J., Hinzová, E., Vorácová, B.: The role of the histocompatibility-2-linked SS-Slp region in the control of mouse complement. Proc. nat. Acad. Sci. (Wash.) 70, 863–866 (1973)

    Google Scholar 

  • Delmas-Marsalet, Y., Hors, J., Colombani, J., Dausset, J.: Study of HL-A genotypes in a case of familial chronic lymphocytic leukaemia (CLL). Tissue Antigens 4, 441–445 (1974)

    Google Scholar 

  • Edwards, J. H., Allen, F. H., Jr., Glenn, K. P., Lamm, L. U., Robson, E. B.: The linkage relationship of HL-A. Histocompatibility Testing 1972, pp 745–751. Copenhagen: Munksgaard 1973

    Google Scholar 

  • Ferreira, A., Nussenzweig, V.: Genetic linkage between serum levels of the third component of complement and the H-2 complex. J. exp. Med. 141, 513–517 (1975)

    Google Scholar 

  • Fu, S. M., Kunkel, H. G., Brusman, H. P., Allen, F. H., Jr., Fotino, M.: Evidence for linkage between HL-A histocompatibility genes and those involved in the synthesis of the second component of complement. J. exp. Med. 140, 1108–1111 (1974)

    Google Scholar 

  • Götze, O., Müller-Eberhard, H. J.: Isolation of the precursor and the active form of the C3 proactivator from human serum. J.Immunol. 107, 313 (1971a) (Abstr.)

    Google Scholar 

  • Götze, O., Müller-Eberhard, H. J.: The C3-activator system. An alternative pathway of complement activation. J. exp. Med. 134, 89–95 (1971b)

    Google Scholar 

  • Haupt, H., Heide, K.: Isolierung und Eigenschaften eines β2-Glykoproteins aus Humanserum. Clin. chim. Acta 12, 419–423 (1965)

    Google Scholar 

  • Hunzicker, L. G., Ruddy, S., Carpenter, C. B., Schur, P. H., Merrill, J. P., Müller-Eberhard, H. J., Austen, K. F.: Metabolism of third complement component (C3) in nephritis. Involvement of the classic and alternate (properdin) pathways for complement activation. New Engl. J. Med. 287, 835–840 (1972)

    Google Scholar 

  • Jongsma, A., van Someren, H., Westerveld, A., Hagemeijer, A., Pearson, P.: Localization of genes on human chromosomes using human-Chinese hamster somatic cell hybrids. Assignment of PGM3 to chromosome C6 and regional mapping of the PGD, PGM1 and Pep-C genes on chromosome A1. Humangenetik 20, 195–202 (1973)

    Google Scholar 

  • Lachman, P. J.: Remark at the Second International Congress of Immunology, Brighton, England, 1974

  • Lamm, L. U., Jensen, K. B.: An abnormal phosphoglucomutase component in chronic lymphatic leukaemia. Scand. J. Haemat. 7, 243–246 (1970)

    Google Scholar 

  • Lamm, L. U., Svejgaard, A., Kissmeyer-Nielsen, F.: PGM3-HL-A is another linkage in man. Nature (Lond.) New Biol. 231, 109–110 (1971)

    Google Scholar 

  • Lilly, F.: H-2, membranes and viral leukemogenesis. Cellular Interactions in the Immune Response. 2nd Int. Convoc. Immun., Buffalo, N.Y., 1970, pp. 103–108. Basel: Karger 1971

    Google Scholar 

  • Maynard-Smith, Sh., Penrose, L. S., Smith, C. A. B.: Mathematical talbes for research workers in human genetics. London: Churchill 1961

    Google Scholar 

  • McDevitt, H. O., Benacerraf, B.: Genetic control of specific immune responses. Advanc. Immunol. 11, 31–40 (1969)

    Google Scholar 

  • Mempel, W., Albert, E. D., Burger, A.: Further evidence for a separate MLC locus. Tissue Antigens 2, 250–254 (1972)

    Google Scholar 

  • Mempel, W., Grosse-Wilde, H., Albert, E. D., Thierfelder, S.: Atypical MLC reactions in HL-A typed related and unrelated pairs. Transplant. Proc. 5, 401–404 (1973)

    Google Scholar 

  • Mempel, W., Grosse-Wilde, H., Netzel, B., Bertrams, J., Albert, E. D.: Definition and population studies of LD determinants in man. Transplant. Proc. (in press)

  • Oldstone, M. B. A., Dixon, F. J.: Acute viral infection: Tissue injury mediated by anti-viral antibody through a complement effector system. J. Immunol. 107, 1274–1280 (1971)

    Google Scholar 

  • Race, R. R., Sanger, R.: Blood groups in man, 5th ed. Oxford-Edinburgh: Blackwell 1968

    Google Scholar 

  • Rittner, Ch., Kalbheim, H.-D.: Phosphoglucomutase 3: Formal and population genetics and observations on abnormal phenotypes. Vox Sang. (Basel) (in press)

  • Rittner, Ch., Rittner, B., Scholz, S., Lorenz, H., Albert, E. D.: Data on a “new” linkage group: HL-A-Bf (factor B of the properdin system). Z. Immun.-Forsch. (in press) (Abstr)

  • Ruley, E. J., Forristal, J., Davis, N. C., Andres, C., West, C. D.: Hypocomplementemia of membranoproliferative nephritis. Dependence of the nephritic factor reaction on properdin factor B. J. clin. Invest. 52, 896–904 (1973)

    Google Scholar 

  • Shreffler, D. C., Klein, J.: Genetic organization and gene action of mouse H-2 region. Transplant. Proc. 2, 5–8 (1970)

    Google Scholar 

  • Someren, H. van, Westerveld, A., Hagemeijer, A., Mees, J. R., Meera Khan, P.: Human antigen and enzyme markers in man-Chinese hamster somatic cell hybrids: Evidence for synteny between HL-A, PGM3, ME1, and IPO-B loci. Proc. nat. Acad. Sci. (Wash.) 71, 962–965 (1974)

    Google Scholar 

  • Teisberg, P.: High voltage agarose gel electrophoresis in the study of the C3 polymorphism. Vox Sang. (Basel) 19, 47–56 (1970)

    Google Scholar 

  • Terasaki, P. I., McClelland, J. D.: Microdroplet assay of human serum cytotoxins. Nature (Lond.) 204, 998–1000 (1964)

    Google Scholar 

  • Thorsby, E.: The human major histocompatibility system. Transplant. Rev. 18, 51–126 (1974)

    Google Scholar 

  • Vogel, F., Helmbold, W.: Blutgruppen-Populationsgenetik und Statistik. In: Humangenetik (ed. P. E. Becker), Vol. I/4, pp. 129–557 (1972)

  • Weitkamp, L. R., van Rood, J. J., Thorsby, E., Bias, W., Fotino, M., Lawler, S. D., Dausset, J., Mayr, W. R., Bodmer, J., Ward, F. E., Seignalet, J., Payne, R., Kissmeyer-Nielsen, F., Gatti, R. A., Sachs, J. A., Lamm, L. U.: The relation of parental sex and age to recombination in the HL-A system. Hum. Hered. 23, 197–205 (1973)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für gerichtliche Medizin der Universität Bonn, Bonn, Germany

    Ch. Rittner & B. Rittner

  2. Institut für Hämatologie der Gesellschaft für Strahlen-und Umweltforschung mbH., München

    H. Grosse-Wilde & B. Netzel

  3. Tissue Typing Laboratory, Kinderpoliklinik München, Munchen, Germany

    S. Scholz, H. Lorenz & E. D. Albert

Authors
  1. Ch. Rittner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Grosse-Wilde
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. Rittner
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. Netzel
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Scholz
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. Lorenz
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. E. D. Albert
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported in part by grants from Deutsche Forschungsgemeinschaft (Ri 164/8, Al 92/9 and Sonderforschungsbereich 37 München).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rittner, C., Grosse-Wilde, H., Rittner, B. et al. Linkage group HL-A-MLC-Bf (properdin factor B). Hum Genet 27, 173–183 (1975). https://doi.org/10.1007/BF00278344

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00278344

Keywords

Search

Navigation