Summary
Different cases in which chromosomes obtained from short-term lymphocyte cultures appear with separated centromeres are reviewed. These include: (1) C-anaphases in the colchicine-resistance mutation, (2) C-anaphases as a common variant, (3) premature centromere division (PCD) in elderly women, (4) PCD in Alzheimer's disease, (5) early splitting and puffing of centromeres in Roberts' syndrome.
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Chamla, Y. C-anaphases in lymphocyte cultures versus premature centromere division syndromes. Hum Genet 78, 111–114 (1988). https://doi.org/10.1007/BF00278177
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DOI: https://doi.org/10.1007/BF00278177