Skip to main content
Log in

C-anaphases in lymphocyte cultures versus premature centromere division syndromes

  • Review
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

Different cases in which chromosomes obtained from short-term lymphocyte cultures appear with separated centromeres are reviewed. These include: (1) C-anaphases in the colchicine-resistance mutation, (2) C-anaphases as a common variant, (3) premature centromere division (PCD) in elderly women, (4) PCD in Alzheimer's disease, (5) early splitting and puffing of centromeres in Roberts' syndrome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Abruzzo MA, Mayer M, Jacobs PA (1985) Aging and aneuploidy: evidence for the preferential involvement of the inactive X chromosome. Cytogenet Cell Genet 39:275–278

    Google Scholar 

  • Battin J, Stanescu V, Stanescu R, Maroteaux P, Joussein M (1977) Chondrodystrophie secondaire à un trouble de la division cellulaire chez deux jumeaux monozygotiques. Arch Fr Pédiatr 34: 233–239

    Google Scholar 

  • Bergener M, Jungklass FK (1970) Genetische Befunde bei Morbus Alzheimer und seniler Demenz. Gerontol Clin 12:71–75

    Google Scholar 

  • Chamla Y, Bégueret J (1982) Colchicine resistance in human cell lines. Pleiotropic phenotype and decreased membrane permeability. Hum Genet 61:73–75

    Google Scholar 

  • Chamla Y, Roumy M, Lassègues M, Battin J (1980) Altered sensitivity to colchicine and PHA in human cultured cells. Hum Genet 53:249–253

    Google Scholar 

  • Daniel A (1979) Single Cd band in dicentric translocations with one suppressed centromere. Hum Genet 48:85–92

    Google Scholar 

  • Eiberg H (1974) New selective Giemsa technique for human chromosomes, Cd staining. Nature 248:55

    Google Scholar 

  • Fitzgerald PH (1975) A mechanism of X chromosome aneuploidy in lymphocytes of aging women. Humangenetik 28:153–158

    Google Scholar 

  • Fitzgerald PH, McEwan CM (1977) Total aneuploidy and age-related sex chromosome aneuploidy in cultured lymphocytes of normal men and women. Hum Genet 39:329–337

    Google Scholar 

  • Fitzgerald PH, Pickering AF, Mercer JM, Meithke PM (1975) Premature centromere division: a mechanism on non-disjunction causing X chromosome aneuploidy in somatic cells of man. Ann Hum Genet 38:417–428

    Google Scholar 

  • Fitzgerald PH, Archer SA, Morris CM (1986) Evidence for the repeated primary non-disjunction of chromosome 21 as a result of premature centromere division (PCD). Hum Genet 72:58–62

    Google Scholar 

  • Freeman MVR, Williams DW, Schimke RN, Temtamy SA, Vachier E, German J (1974) The Roberts' syndrome. Clin Genet 5:1–16

    Google Scholar 

  • Gabarron J, Jimenez A, Glover G (1986) Premature centromere division dominantly inherited in a subfertile family. Cytogenet Cell Genet 43:69–71

    Google Scholar 

  • German J (1979) Roberts' syndrome. I. Cytological evidence for a disturbance in chromatid pairing. Clin Genet 16:441–447

    Google Scholar 

  • Moorhead PS, Heyman A (1983) Chromosome studies of patients with Alzheimer disease. Am J Med Genet 14:545–556

    Google Scholar 

  • Moreau PJF, Zickler D, Leblon G (1985) One class of mutants with disturbed centromere cleavage and chromosome pairing in Sordaria macrospora. Mol Gen Genet 198:189–197

    Google Scholar 

  • Nakagome Y, Teramura F, Kataoka K, Hosono F (1976) Mental retardation, malformation syndrome and partial 7p monosomy [45,XX, t dic (7;15)(q21; p11)]. Clin Genet 9:621–624

    Google Scholar 

  • Nakagome Y, Abe T, Misawa S, Takeshita T, Inuma K (1984) The “loss” of centromeres of aged women. Am J Hum Genet 36:398–404

    Google Scholar 

  • Oaks MK, O'Malley DP, Kateley JR, Maldonado WE (1987) Detection of centromeric regions of chromosomes by immunofluorescence: procedure and application. J Med Genet 24:498–499

    Google Scholar 

  • Parry DM, Mulvihill JJ, Tsai S, Kaiser-Kupfer MI, Cowan JM (1986) SC phocomelia syndrome, premature centromere separation, and congenital cranial nerve paralysis in two sisters, one with malignant melanoma. Am J Med Genet 24:653–672

    Google Scholar 

  • Römke C, Froster-Iskenius U, Heyne K, Höhn W, Hof M, Grzejszczyk G, Rauskolb R, Rehder H, Schwinger E (1987) Roberts syndrome and SC phocomelia. A single genetic entity. Clin Genet 31:170–177

    Google Scholar 

  • Rudd NL, Teshima IE, Martin RH, Sisken JE, Weksberg R (1983) A dominantly inherited cytogenetic anomaly: a possible cell division mutant. Hum Genet 65:117–121

    Google Scholar 

  • Scheres JMJC, Hustinx TWJ, Madan K, Beltman JD, Lindhout D (1986) A mitotic mutant causing non-disjunction in man. 9th International Chromosome Conference, Marseilles 1986 (abstr)

  • Tomkins D, Hunter A, Roberts M (1979) Cytogenetic findings in Roberts'-SC phocomelia syndrome(s). Am J Med Genet 4:17–26

    Google Scholar 

  • Zergollern L, Hitrec V (1982) Four siblings with Roberts' syndrome. Clin Genet 21:1–6

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chamla, Y. C-anaphases in lymphocyte cultures versus premature centromere division syndromes. Hum Genet 78, 111–114 (1988). https://doi.org/10.1007/BF00278177

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00278177

Keywords

Navigation