Summary
Although glucagon-like peptide-1 has the appearance of a glucagon-homologue that may be co-secreted with glucagon, synthetic glucagon-like peptide-1-(1–37) does not significantly affect plasma glucose and insulin concentrations when administered at high doses (100 and 400 μg) to cortisone-pretreated rabbits. This synthetic preparation thus lacks the primary metabolic effect of glucagon at the doses tested. An intra- or extra-pancreatic role of glucagon-like peptide-1 has yet to be discovered.
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References
Bell GI, Santerre RF, Mullenbach GT (1983) Hamster preproglucagon contains the sequence of glucagon and two related peptides. Nature 302: 716–718
Lopez LC, Frazier ML, Su C-J, Kumar A, Saunders GF (1983) Mammalian pancreatic preproglucagon contains three glucagonrelated peptides. Proc Natl Acad Sci USA 80: 5485–5489
Bell GI, Sanchez-Pescador R, Laybourn PJ, Najarian RC (1983) Exon duplication and divergence in the human preproglucagon gene. Nature 304: 368–371
Lund PK, Goodman RH, Montminy MR, Dee PC, Habener JF (1983) Angler-fish islet pre-proglucagon. II. Nucleotide and corresponding amino acid sequence of the cDNA. J Biol Chem 258: 3280–3284
Merrifield RB (1963) Solid phase synthesis. J Am Chem Soc 85: 2149–2156
Tarding F, Nielsen P, Keiser-Nielsen B, Nielsen AV (1969) Biological assay of glucagon in rabbits. Diabetologia 5: 146–154
Albano JDM, Ekins RP, Maritz G, Turner RC (1972) A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties. Acta Endocrinol 70: 487–509
Holst JJ (1983) Gut glucagon, enteroglucagon, gut glucagon-like immunoreactivity, glicentin — current status. Gastroenterology 84: 1602–1613
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Ghiglione, M., Uttenthal, L.O., George, S.K. et al. How glucagon-like is glucagon-like peptide-1?. Diabetologia 27, 599–600 (1984). https://doi.org/10.1007/BF00276976
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DOI: https://doi.org/10.1007/BF00276976