Abstract
The only possible treatment of non-removable tumors of the diencephalon or recurring tumors invading the diencephalon after partial resection or percutaneous radiotherapy is interstitial irradiation (Curie therapy). With the CT/MRI stereotactic method, biopsy for histological tumor classification can be performed and 125I or 192Ir implanted, provided the neuroimaging methods show the delimitation of the tumor, its diameter does not exceed 3 cm and, given the patient's condition, focal irradiation seems advisable. As of 31 August 1987, a total of 1883 cases had been stereotactically biopsied and interstitially irradiated. The indications and results are reported in 204 patients under 18 years of age with diencephalic and deep-seated astrocytomas, after a follow-up period of up to 10 years; the data were compared for tumor resection, percutaneous irradiation, and for interstitial irradiation. The latter proved to be the most effective treatment.
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References
Beks JWF, Bouma GJ, Journée HL (1987) Tumors of the thalamic region. A retrospective study of 27 cases. Acta Neurochir (Wien) 85:125–127
Bernstein M, Gutin PH (1981) Interstitial irradiation of brain tumors: a review. Neurosurgery 9:741–750
Bernstein M, Hoffman HJ, Halliday WC, Hendricks EB, Humphreys RP (1984) Thalamic tumors in children. Long-term follow-up and treatment guidelines. J Neurosurg 61:649–656
Gulotta F (1988) Zum biologischen Verhalten niedriggradiger Astrocytome. In: Bamberg M, Sack H (eds) Therapie primärer Hirntumoren. W Zuckschwerdt, Munich, pp 186–189
Hoffman HJ (1982) Supratentorial brain tumors in children. In: Youmans JR (ed) Neurological surgery, vol 5. Saunders, London, pp 2702–2732
Jimenez J (1983) Brain tumors in children. Results of treatment in 138 patients. Neoplasma 30:93–96
Krauseneck P, Richter E, Dittmann W, Müller H-A, Ködel B, Bogdahn U (1988) Zu Indikation und Zeitpunkt der Strahlentherapie bei niedriggradigen Gliomen (WHO I and II). In: Bamberg M, Sack H (eds) Therapie primärer Hirntumoren. W Zuckschwerdt, Munich, pp 205–209
Leibel ASt, Sheline GE (1987) Radiation therapy for neoplasms of the brain. J Neurosurg 66:1–22
Morantz RA (1987) Radiation therapy in the treatment of cerebral astrocytoma. Neurosurgery 20:975–982
Mundinger F (1966) Treatment of brain tumors with radio-isotopes. In: Krayenbühl H, Maspes M, Sweet Ch (eds) Progress of neurological surgery, vol I. Karger, Basel, pp 202–257
Mundinger F (1970) The treatment of brain tumors with interstitially applied radioactive isotopes. In: Yen Wang, Paoletti P (eds) Radionuclide applications in neurology and neurosurgery. Thomas, Springfield, Illinois, pp 199–265
Mundinger F (1982) Stereotactic interstitial therapy of nonresectable intracranial tumors with iridium-192 and iodine-125. In: Kärcher KH, Kogelnik HD, Reinartz G (eds) Progress in radiooncology II. Raven Press, New York, pp 371–380
Mundinger F (1982) Implantation of radioisotopes (Curie therapy). In: Schaltenbrand, Walker (eds) Textbook of sterotaxy of the human brain. Thieme, Stuttgart, pp 410–435
Mundinger F (1986) Stereotactic biopsy and technique of implantation (installation) of radionuclides. In: Jellinger K (ed) Therapy of malignant brain tumors. Springer, Heidelberg Berlin New York, pp 134–194
Mundinger F (1988) Stereotactic biopsy and implantation of radionuclides guided by computed tomography or magnetic resonance imaging for therapy of brain tumors. In: Schmidek HH, Sweet WH (eds) Operative neurosurgical techniques, vol I. Grune & Stratton, London, pp 491–514
Mundinger F, Weigel K (1988) Considerations in the usage and results of Curie therapy. In: Dade Lundsford (ed) Modern stereotactic neurosurgery. Martinus Nijhoff, Boston, pp 245–258
Ostertag CB, Burger PC, Leetz H-K, Kleihues P, Warnke PC (1988) Experimentelle Dosiseffekte nach interstitieller Bestrahlung des Gehirns. In: Bamberg M, Sack H (eds) Therapie primärer Hirntumoren. W Zuckschwerdt, Munich, pp 279–283
Schulte FJ (1984) Intracranial tumors in childhood — concepts of treatment and prognosis. Neuropediatrics 15:25–27
Thiel HJ, Sauer R, Müller RG, Huk W, Schmidt H, Thierauf P (1988) Kombinierte interstitielle und perkutane Bestrahlung von Hirngliomen: Probleme der Dosierung und der Dosisverteilung. In: Bamberg M, Sack H (eds) Therapie primärer Hirntumoren. W Zuckschwerdt, Munich, pp 291–296
Wendt ThG, Willich N, Rohloff R (1988) Stellenwert der Strahlentherapie in der Behandlung niedrigmaligner Großhirnmalignome. In: Bamberg M, Sack H (eds) Therapie primärer Hirntumoren. W Zuckschwerdt, Munich, pp 201–203
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Etou, A., Mundinger, F., Mohadjer, M. et al. Stereotactic interstitial irradiation of diencephalic tumors with iridium 192 and iodine 125: 10 years follow-up and comparison with other treatments. Child's Nerv Syst 5, 140–143 (1989). https://doi.org/10.1007/BF00272114
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DOI: https://doi.org/10.1007/BF00272114