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Metabolic and hemodynamic response to hyperventilation in patients with head injuries

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Abstract

The effects of controlled moderate hyperventilation (paCo2∼31 mmHg) on cardiovascular parameters and whole-body-oxygen-uptake (\(\dot VO_2 \))was studied in 10 patients with head injuries, who were unconscious and artificially ventilated at the time of the investigation. \(\dot VO_2 \)was measured with the Beckmann Metabolic Measurement Cart and also calculated from cardiac output and arterio-mixed venous oxygen content difference. A mean increase in \(\dot VO_2 \)(+19.6% of control) was observed after 2 h of hyperventilation. Cardiac output remained unchanged. This resulted in a decrease of venous oxygen content and impaired full oxygenation of the blood. Our results indicate that hyperventilation should not be a routine procedure. Close monitoring of arterial and venous blood gases is recommended, when hyperventilation is applied.

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Authors and Affiliations

  1. Centre for Anaesthesiology, University of Göttingen School of Medicine, Göttingen, FRG

    E. Turner, O. Hilfiker & U. Braun

  2. Neurological Medicine, University of Göttingen School of Medicine, Göttingen, FRG

    W. Wienecke & B. Rama

  3. Zentrum Anaesthesiologie, Universität Göttingen, D-3400, Göttingen, FRG

    E. Turner

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  1. E. Turner
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  2. O. Hilfiker
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  4. W. Wienecke
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  5. B. Rama
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Turner, E., Hilfiker, O., Braun, U. et al. Metabolic and hemodynamic response to hyperventilation in patients with head injuries. Intensive Care Med 10, 127–132 (1984). https://doi.org/10.1007/BF00265801

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