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Effects of cisplatin on different measures of glomerular function in the human kidney with special emphasis on high-dose

  • Original Articles
  • GFR, Creatinine, Creatinine Clearance, Proteinuria
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Summary

To investigate the effect of high-dose cisplatin (40 mg/m2 daily for 5 days), 51Cr-EDTA clearance was used as a measure of glomerular filtration rate (GFR). 51Cr-EDTA clearance decreased significantly from 109±3 ml/min * 1.73 m2 to 68±3 ml/min * 1.73 m2 after three cycles of cisplatin and remained at this decreased level during the observation period (24 months). To determine the reliability of creatinine as a measure of GFR, we compared the simultaneous clearance of creatinine to that of 51Cr-EDTA. A good correlation between 51Cr-EDTA clearance and creatinine clearance was observed before and 3 months after termination of treatment, but no correlation was found during treatment. S-creatinine decreased significantly during treatment, probably due to muscle wasting. We conclude that s-creatinine and creatinine clearance are unsuitable measures of glomerular function during high-dose cisplatin treatment. All patients developed proteinuria during treatment. The changes in clearance ratios of beta-2-microglobulin/albumin and IgG/albumin show that the proteinuria observed during cisplatin infusion is predominantly of tubular origin, whereas the proteinuria between the treatment periods is mainly of glomerular origin.

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Authors and Affiliations

  1. Department of Oncology ONB, The Finsen Institute, Copenhagen, Denmark

    Gedske Daugaard & Mikael Rørth

  2. Department of Clinical Physiology, The Finsen Institute, Strandboulevarden 49, DK-2100, Copenhagen, Denmark

    Gedske Daugaard & Niels Rossing

Authors
  1. Gedske Daugaard
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  2. Niels Rossing
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  3. Mikael Rørth
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Daugaard, G., Rossing, N. & Rørth, M. Effects of cisplatin on different measures of glomerular function in the human kidney with special emphasis on high-dose. Cancer Chemother. Pharmacol. 21, 163–167 (1988). https://doi.org/10.1007/BF00257365

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  • DOI: https://doi.org/10.1007/BF00257365

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