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Effect of D-mannose and D-glucose on Escherichia coli bacteriuria in rats

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Summary

The effect of D-mannose and D-glucose on bacteriuria due to Escherichia coli with mannose-sensitive adhesins was investigated in adult male Sprague-Dawley rats undergoing diuresis. Inocula of 105, 107, or 108 bacteria in 0.1 ml of normal saline or 2.5% or 10% D-mannose or D-glucose were injected intravesically and urine was cultured 1, 3, 5, 7 and 9 days later. The levels of bacteriuria on days 1 and 5 were significantly lower in rats inoculated with 105 E. coli and 10% D-mannose than in controls (p<0.05 and 0.01 respectively) and the percentages of rats with < 100 bacteria/ml were higher on days 1 and 3 (p=0.05 and 0.02 respectively). Bacteriuria was significantly lower in rats inoculated with 107 bacteria and 10% D-mannose than in controls on days 5 and 7 (p<0.01 for each day) and the percentage of rats with <100 bacteria/ml was higher on day 7 (p=0.01). D-glucose reduced bacteriuria significantly only with a concentration of 10% after instillation of 105 E. coli (p<0.05, day 1). The results indicate that D-mannose and D-glucose can significantly reduce bacteriuria within 1 day and that their efficacy is dependent upon the concentration of both saccharide and bacteria.

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Author notes

  1. E. K. Michaels

    Present address: Department of Urology, Loyola Medical Center, Maywood, Illinois, USA

Authors and Affiliations

  1. Department of Urology, Northwestern University Medical School, Chicago, Illinois, USA

    E. K. Michaels, B. J. Plotkin &  A. J. Schaeffer

  2. Department of Community Health and Preventive Medicine, Cancer Center Biometry Section, Northwestern University Medical School, Chicago, Illinois, USA

    J. S. Chmiel

Authors
  1. E. K. Michaels
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  2. J. S. Chmiel
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  3. B. J. Plotkin
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  4. A. J. Schaeffer
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Michaels, E.K., Chmiel, J.S., Plotkin, B.J. et al. Effect of D-mannose and D-glucose on Escherichia coli bacteriuria in rats. Urol. Res. 11, 97–102 (1983). https://doi.org/10.1007/BF00256954

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