Summary
Myxovirescin A is a new antibiotic from Myxococcus virescens. Conditions of growth on peptone media result in the antibiotic being secreted during the transition to the stationary phase. When growth is exponential, no detectable production occurs.
In an attempt to improve production of the antibiotic, peptone was fed to the peptone-limited culture at differing feed rates. Product formation was found to be dependent on the peptone supply, and the product concentration could be improved from 0.04 to 2 mg/l myxovirescin A.
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References
Gerth K, Irschik H, Reichenbach H, Trowitzsch W (1982) The myxovirescins, a family of antibiotics from Myxococcus virescins (Myxobacterales). J Antibiotics 35:1454–1459
Lehmann J, Berthe-Corti L, Steven W, Nothnagel J, Piehl G-W, Gerth K “Offenlegungsschrift 2924868”, Deutsches Patentamt 1981, Application 1979
Trowitzsch W, Wray V, Gerth K, Höfle G (1982) Structure of myxovirescin A, a new macrocyclic antibiotic from gliding bacteria. J Chem Soc Chem Commun 1340–1342
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Article No. 13 on antibiotics from gliding bacteria Article No. 12: Thierbach G, Reichenbach H (1983). The effect of the new antibiotic myxothiazol on the respiration of Paracoccus denitrificans. Arch Microbiol 134: 104–107
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Nigam, J.N., Lehmann, J., Gerth, K. et al. Feeding strategy for the production of the new antibiotic myxovirescin A from Myxococcus virescens (Myxobacterales). Appl Microbiol Biotechnol 19, 157–160 (1984). https://doi.org/10.1007/BF00256447
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DOI: https://doi.org/10.1007/BF00256447