Summary
Gestational diabetes is a clinical entity associated with a significant incidence in diabetes in the later life of the mother and increase in fetal and neonatal morbidity. Lack of agreement on diagnostic criteria and the methodology of glucose tolerance testing has led to inconsistency in the results of published studies. It is recommended that all women should be screened for carbohydrate intolerance in pregnancy.
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Hadden DR (1980) Screening for abnormalities of carbohydrate metabolism in pregnancy 1966-77. The Belfast experience. Diabetes Care 3: 440–446
White P (1965) Pregnancy and diabetes. Medical aspects. Med Clin North Am 49: 1015–1024
Pedersen J (1977) The pregnant diabetic and her newborn. Munksgaard, Copenhagen
Gibbons JM, Nagle MP (1980) Assessing fetal health when the mother is diabetic. Contemp Obgyn 15: 115–124
Freinkel N (1980) Of pregnancy and progeny. Diabetes 20: 1023–1035
O'Sullivan JB (1979) Gestational diabetes: factors influencing the rates of subsequent diabetes. In: Sutherland HW, Stowers JM (eds) Carbohydrate metabolism in pregnancy and the newborn 1978. Springer Verlag, Berlin, pp 425–435
O'Sullivan JB, Mahan CM (1964) Criteria for the oral glucose tolerance test in pregnancy. Diabetes 13: 278–285
Proceedings of Symposium on Gestational Diabetes (1980) Summary and Recommendations. Diabetes Care 3: 499–501
Pettit DJ, Knowler WC, Baird R, Bennett PH (1980) Gestational diabetes: infant and maternal complications of pregnancy in relation to third trimester glucose tolerance in Pima Indians. Diabetes Care 3: 458–464
Merkatz IR, Duchon MA, Yamashita TS, Houser HB (1980) A pilot community based screening programme for gestational diabetes. Diabetes Care 3: 453–457
Gillmer MDG, Oakley NW, Beard RW, Nithyananthan R, Cawston M (1980) Screening for diabetes during pregnancy. Br J Obstet Gynaecol 87: 377–382
O'Sullivan JB (1980) Establishing criteria for gestational diabetes. Diabetes Care 3: 437–439
Kučera J (1971) Rate and type of congenital anomalies among offspring of diabetic women. J Reprod Med 7: 73–82
Naeye RL (1965) Infants of diabetic mothers — a quantitative morphological study. Pediatrics 35: 980–985
Pedersen LM, Tygstrup I, Pedersen J (1964) Congenital malformations in newborn infants of diabetic women. Lancet 1: 1124–1126
Miller E, Hare JW, Cloherty JP, Dunn PJ, Gleason RE, Soeldner JE, Kitzmiller JL (1981) Elevated maternal HbA1c in early pregnancy and major congenital anomalies in infants of diabetic mothers. New Eng J Med 304: 1331–1333
Leslie RDG, Pyke DA, John PN, White PM (1978) Haemoglobin a1 in diabetic pregnancy. Lancet 2: 958–959
Pedersen LM (1980) Pregnancy and diabetes. A survey. Acta Endocrinol 94:(Suppl 238): 13–19
Malins JM (1979) Fetal anomalies related to carbohydrate metabolism — the epidemiological approach. In: Sutherland HW, Stowers JM (eds) Carbohydrate metabolism in pregnancy and the newborn 1978. Springer-Verlag, Berlin, pp 229–246
Haukkamaa M, Nilsson CG, Luukkaainen J (1980) Screening, management and outcome of pregnancy in diabetic mothers. Obstet Gynecol 55: 596–602
Deuchar EM (1979) Culture in vitro as a means of analysing the effect of maternal diabetes on embryonic development in rats. In: Elliott K, O'Connor M (eds) Pregnancy, metabolism, diabetes and the fetus. CIBA Foundation Symposium No. 63 (new series). Excerpta Medica, Amsterdam, Oxford, New York pp 181–197
Eriksson U (1981) Diabetes in pregnancy. A study of complications in the offspring of the rat. MD Thesis, Acta Universitatis Upsaliensis, Uppsala, Sweden
Baker L, Egler JM, Klein SH, Goldman AS (1981) Meticulous control of diabetes during organogenesis prevents congenital lumbosacral defects in rats. Diabetes 30: 955–959
Yssing M (1975) Long-term prognosis of children born to diabetic mothers when pregnant. In: Camerini-Davalas RA, Cole HS (eds) Early diabetes in early life, Academic Press, New York, pp 575–586
Gabbe SG (1977) Congenital malformations in infants of diabetic mothers. Obstet and Gynecol Surv 32: 125–132
Roversi GD, Gargiulo M, Nicolini U, Pecretti E, Marini A, Barbarini V, Peneff P (1979) A new approach to the treatment of pregnant diabetic women. 479 cases (1963–1975). Am J Obstet Gynecol 135: 567–576
Gyves MT, Schulman PK, Merkatz IM (1980) Results of individualised intervention in gestational diabetes. Diabetes Care 3: 495–496
Gabbe SG, Mestman JH, Freeman RK, Anderson GV, Lowensohn RI (1977) Management and outcome of class A diabetic mellitus. Am J Obstet Gynecol 127: 465–469
Karlsson K, Kjellmer I (1972) The outcome of diabetic pregnancies in relation to the mothers blood sugar level. Am J Obstet Gynecol 112: 213–217
Jarrett R (1981) Reflections on gestational diabetes. Lancet 2: 1220–1222
O'Sullivan JB, Charles D, Mahan CM, Dandrow RV (1973) Gestational diabetes and perinatal mortality rate. Am J Obstet Gynecol 116: 901–904
Mestman JH (1980) Outcome of diabetes screening in pregnancy and perinatal morbidity in infants of mothers with mild impairment in glucose tolerance. Diabetes Care 3: 477–452
Muck BR, Christ F (1973) Pathologische Glukosetoleranz bei Schwangeren. Eine Untersuchung des geburtshilflichen Kollektivs der Erlanger Universitäts-Frauenklinik 1971. Arch Gynaekol 215: 95–109
O'Sullivan JB (1975) Insulin treatment for gestational diabetes. In: Camerini-Davalos RA, Cole HS (eds). Early diabetes in early life. Academic Press, New York, pp 447–453
O'Sullivan JB, Mahan CM (1980) Insulin treatment and high risk groups. Diabetes Care 3: 482–485
Isles TE, Dickson M, Farquahar JN (1968) Glucose tolerance and plasma insulin in newborn infants of normal and diabetic mothers. Pediat Res 2: 198–208
Molsted-Pedersen L (1972) Aspects of carbohydrate metabolism in newborn infants of diabetic mothers — intravenous glucose tolerance tests. Acta Endocrinol 69: 174–188
Hulquist GT, Olding L (1975) Pancreatic islet fibrosis in young infants of diabetic mothers. Lancet 2: 1015–1016
Jovanovic L, Druzin M, Peterson CM (1981) Effect of euglycemia on the outcome of pregnancy in insulin-dependent diabetic women as compared with normal control subjects. Am J Med 71: 921–927
Hoet JJ, Beard RW (1979) Clinical perspectives in the care of the pregnant diabetic patient. In: Elliott K, O'Conner M (eds). Pregnancy, metabolism, diabetes and the fetus. CIBA Foundation Symposium No 63 (new series). Excerpta Medica, Amsterdam, Oxford, New York, pp 283–300
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Beard, R.W., Hoet, J.J. Is gestational diabetes a clinical entity?. Diabetologia 23, 307–312 (1982). https://doi.org/10.1007/BF00253735
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DOI: https://doi.org/10.1007/BF00253735