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Über Hemmungs- und Potenzierungs-Phänomene am quergestreiften Muskel

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Summary

1. Studies were carried out on isolated striated muscles (M. Rectus abdom. of frogs), which were previously inhibited by four groups of different organic compounds: a) Amides, Amidines and Diamidines, b) Guanidine, Creatine and Diguanidines, c) Localanesthetics, d) Thiols. The muscles were then treated with the following muscle-stimulants: Prostigmine, the prostigmine like quaternary ammonium bases Tensilon (3-hydroxyphenyldimethylethylammoniumchloride [RO 2-3198]) and 3-hydroxyphenyltrimethylammoniumbromide (RO 2-2561) as well as Tetraethylpyrophosphate. Of these drugs Tensilon was blocked most readily, followed by RO 2-2561; Prostigmine and Tetraethylpyrophosphate as the stronger stimulants, were also more difficult to block

2. The inhibited muscles, even after failing to react to the above mentioned stimulants, are sensitized by these ineffective compounds to respond with a strong contraction on addition of small doses of Acetylcholine or Potassium chloride, which alone would be unable to produce contraction of the inhibited or even the normal muscle (Potentiation of Acetylcholine or Potassiumchloride by inhibited muscle-stimulants).

3. The inhibited muscles are sensitized, on the other hand, by the addition of small, apparently ineffective amounts of Acetylcholine or Potassiumchloride, because in their presence the above mentioned otherwise inactive muscle-stimulants induce a maximum contraction (Potentiation of muscle-stimulants by inhibited Acetylcholin or Potassiumchloride.)

4. Both these potentiation-phenomena a) the potentiation of Acetylcholine or Potassiumchloride by inhibited muscle-stimulants and b) the potentiation of muscle-stimulants by inhibited Acetylcholine or Potassiumchloride are explained as results of depolarisation and increased permeability of muscle-cells and muscle-membranes primarily by Acetylcholine and Potassiumchloride with similar though weaker additive effects of the muscle-stimulants (Potentiation by depolarisation).

5. These experiments serve to emphasize the important function of Acetylcholine and Potassium-ions in the sensitization and contraction of the isolated inhibited muscle.

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Authors and Affiliations

  1. Aus dem „Merck Institute for Therapeutic Research“ Rahway, N. Y., USA

    E. P. Pick, H. L. Hollinck & G. Zacharellis

  2. der pharmakol. Abteilung des Mount Sinai Hospitals, N. Y., USA

    E. P. Pick, H. L. Hollinck & G. Zacharellis

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  1. E. P. Pick
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Zur Feier des 80. Geburtstages von Professor Dr. Otto Loewi in alter Freundschaft und aufrichtiger Verehrung.

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Pick, E.P., Hollinck, H.L. & Zacharellis, G. Über Hemmungs- und Potenzierungs-Phänomene am quergestreiften Muskel. Naunyn - Schmiedebergs Arch 220, 83–99 (1953). https://doi.org/10.1007/BF00246097

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