Summary
The pathologic grasp reflex (“forced grasping”) was used to study restitution of function in monkeys conditioned to grasp and release a stick for food. Cortical lesions (area 6) made it impossible for the animals to relinquish the stick or to avoid grasping an unconditioned (tactile) stimulus. Normal tactile evasion was abolished but returned during recovery, i.e. as forced grasping waned. Pyramidal lesions alone provoked no forced grasping but abolished all tactile reflexes. Seriatim cortical and pyramidal (1 year later) lesions brought back pathological grasping after “total” restitution of normal grasping had occurred, whereas ventrolateral spinal lesions hastened restitution and enhanced tactile evasion. The possible mechanisms underlying restitution are discussed; it is suggested that the abnormal grasp is compensated by enhancement of its opposing reflex, tactile evasion, which is subserved by the pyramid. The fundamental physiological change due to area 6 lesion is a reflex imbalance which endures covertly in spite of behavioral restitution and is exposed once again when tactile evasion is abolished by pyramidotomy. Therefore, during “recovery”, pyramidal function vis a vis tactile evasion was enhanced in response to loss of inhibitory control over tactile and proprioceptive grasp reflex activity. This model is offered as an alternative to “functional reorganization” and “vicarious function”.
Similar content being viewed by others
References
Adie, W.J., Critchley, M.: Forced grasping and groping. Brain 50, 142–170 (1927).
Beck, C.H., Chambers, W.W.: Speed, accuracy and strength of forelimb movement after unilateral pyramidotomy in rhesus monkeys. J. comp. physiol. Psychol. 70, 1–22 (1970).
Bernhard, C.G., Bohm, E.: Monosynaptic cortico-spinal activation of forelimb motorneurons in monkeys (macaca mulatta). Acta physiol. scand. 31, 104–122 (1954).
Bonin, G. von, Bailey, P.: The Neocortex of Macaca Mulatta. University of Ill. Press 1947.
Brodal, A.: Experimental Anatomical Studies of the Corticospinal and Cortico-Rubro-Spinal Connections in the cat. Sump. Biol. Hung. 5, 207–217 (1965).
Chambers, W.W., Kozart, D.: Conditioned tactile discrimination of monkey with corticospinal or pyramidal tract lesions. Anat. Rec. 151, 499 (1965).
Denny-Brown, D.: The cerebral Control of Movement. University of Liverpool 1966.
Eccles, J.C., Ito, M., Szenthágothai, J.: Cerebellum as a Neuronal Machine. Berlin-Heidelberg-New York: Springer 1967.
Fulton, J.F.: Forced grasping and groping in relation to the syndrome of permotor area: A physiological analysis. Arch. Neurol. Psychiat. (Chic.) 31, 221–235 (1934).
Glaser, G.H., Higgins, D.C.: Motor Stability Stretch Responses and the Cerebellum. In: R. Granit, Ed. Muscular afferents and Motor Control, pp. 121–139. Nobel Symposium I: New York: Wiley 1966.
Goldberger, M.E.: The extrapyramidal systems of the spinal cord: results of combined spinal and cortical lesions in the Macaque. J. comp. Neurol. 124, 161–174 (1965).
—: The extrapyramidal systems of the spinal cord: II. Results of combined pyramidal and extrapyramidal lesions in the macaque. J. comp. Neurol. 135, 1 (1969).
—, Growdon, J.: Cerebellar tremor and ataxia: The role of the cerebral cortex in recovery. Anat. Rec. 163, 190 (1969).
Goodman, D.C., Horel, J.A.: Sprouting of Optic Tract projections in the Brain Stem of the Rat. J. comp. Neurol. 27, 71–88 (1966).
Growdon, J.H., Chambers, W.W., Liu, C.N.: An experimental Study of Cerebellar Dyskinesia in the Rhesus Monkey. Brain 90, 603–632 (1967).
Hines, M.: The development and regression of reflexes, postures and progression in the young macaque. Contr. Embryol. Carneg. Instn. 30, 154–217 (1942).
Holmquist, B., Lundberg, A.: Differential supraspinal control of synaptic actions evoked by volleys in the flexion reflex afferents in alpha motoneurons. Acta physiol. scand. 54, Suppl. 186, 5–51 (1961).
Jackson, J.H.: On the Anatomical and Physiological Localization of movements in the Brain. Brit. med. J. (1974).
Jacobsen, C.F., Taylor, F.B., Haslerud, G.M.: Restitution of function after cortical injury in monkeys. Amer. J. Physiol. 116, 85–86 (1936).
Kennard, M.A.: Reorganization of motor function in the cerebral cortex of monkeys deprived of motor and premotor areas in infancy. J. Neurophysiol. 1, 477–496 (1938).
Knapp, H.D., Taub, E., Berman, A.J.: Movements in monkeys with deafferented forelimbs. Exp. Neurol. 7, 105–315 (1936).
Koenig, H., Grand, R.A., Windle, W.F.: A physiological approach to perfusion — fixation of tissue with formalin. Stain Technol. 20, 13–22 (1945).
Lashley, K.S.: Integrative Functions of the Cerebral Cortex. Physiol. Rev. 13, 1–24 (1933).
Lawrence, D.G., Kuypers, H.G.J.M.: The functional organization of the motor system in the monkey. I. The effects of bilateral pyramidal lesions. Brain 91, 1–14 (1968a).
Llinás, R., Terzuolo, C.A.: Mechanisms of supraspinal actions upon spinal cord activities. Reticular inhibitory mechanisms on alpha-extensor motoneurons. J. Neurophysiol. 27, 579–591 (1964).
Lundberg, A., Voorhoeve, P.: Effects from the pyramidal tract on spinal reflex arcs. Acta physiol. scand. 56, 201–219 (1962).
McCouch, G.P., Austin, G.M., Liu, C.N., Liu, C.Y.: Sprouting as a cause of spasticity. J. Neurophysiol. 21, 205–216 (1958).
Peele, T.L.: Acute and chronic parietal lobe ablations in monkeys. J. Neurophysiol. 7, 269–286 (1944).
Preston, J.B., Whitlock, D.C.: Precentral facilitation and inhibition of spinal motoneurons. J. Neurophysiol. 23, 154–170 (1960).
—: Intracellular potentials recorded from motoneurons following precentral gyrus stimulation in primate. J. Neurophysiol. 24, 91–100 (1961).
Raisman, G.: Neuronal Plasticity in the Septal Nuclei of the Adult Rat. Brain Res. 14, 25–48 (1969).
Richter, C.F., Hines, M.: The production of the grasp reflex in adult macaques by experimental frontal lobe lesions. Res. Publ. Ass. nerv. ment. Dis. 13, 211–244 (1934).
Rushworth, G., Denny-Brown, D.: The two components of the grasp reflex after ablation of the frontal cortex in monkeys. J. Neurol. Neurosurg. Psychiat. 22, 91–98 (1959).
Schneider, G.E.: Mechanisms of Recovery Following Lesions of Visual Cortex or Superior Collicus in Neonate and Adult Hamsters. Brain Behav. Evol. 3, 295–323 (1970).
Sperry, R.W.: Effect of Crossing Nerves to Antagonistic Limb Muscles in the Monkey. Arch. Neurol. Psychiat. (Chic.) 58, 452–473 (1947).
Taub, E.: Prism Compensation as a Learning Phenomenon: a Phylogenetic Perspective. In: S.J. Freedman, Ed. The Neuropsychology of Spatially Oriented Behavior. Illinois: Dorsey Press 1968.
Tower, S.S.: Pyramidal and extrapyramidal factors in the production of proprioceptive reflex grasping in the monkey. Amer. J. Physiol. 123, 205 (1938).
—: Pyramidal lesion in the monkey. Brain 63, 36–90 (1490).
Wagley, P.F.: A study of spasticity and paralysis. Bull. Johns Hopk. Hosp. 77, 218–273 (1945).
Wall, P.D.: The laminar organization of dorsal horn and effects of descending impulses. J. Physiol. (Lond.) 188, 403–423 (1967).
Woolsey, C.N., Settlage, H., Moyer, D.P., Sencer, W., Hamuy, T.P., Travis, A.M.: Patterns of localization in percentral and supplementary motor areas and their relation to the concept of a premotor area. Res. Publ. Ass. nerv. ment. Dis. 30, 238–264 (1952).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Goldberger, M.E. Restitution of function in the CNS: The pathologic grasp in Macaca mulatta. Exp Brain Res 15, 79–96 (1972). https://doi.org/10.1007/BF00234959
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00234959