Summary
Intracellular recordings were obtained from medial vestibular nuclei neurones (MVNn) in guinea-pig brainstem slices. Two main distinct neuronal classes were encountered. Type A MVNn (32.3%) were characterized by a broad action potential followed by a deep single afterhyperpolarization, a transient A-like rectification, and a single range of firing in response to current injection. Type B MVNn (47.1%), in contrast, were distinguished by the presence of a thin action potential followed first by a fast and then by a delayed and slower afterhyperpolarization. In addition, they displayed a secondary range of firing in their response to current injection. A majority of B MVNn also had either subthreshold plateau potentials or low threshold spike bursts or a combination thereof. A third, non-homogeneous class of cells, could not be fitted into either one of the two main classes (20.6%, type C MVNn).
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Baker R, Evinger C, McCrea RA (1981) Some thoughts about the three neurons in the vestibulo-ocular reflex. Ann NY Acad Sci 374:171–188
Bilotto G, Goldberg J, Peterson BW, Wilson VJ (1982) Dynamic properties of vestibular reflexes in the decerebrate cat. Exp Brain Res 47:343–352
de Waele C, Vibert N, Baudrimont M, Vidal PP (1990) NMDA receptors contribute to the resting discharge of the vestibular neurons in the normal and hemilabyrinthectomized guinea pig. Exp Brain Res 81:125–133
Goldberg JM, Smith CE, Fernandez C (1984) Relation between discharge regularity and responses to externally applied galvanic currents in vestibular nerve afferents of the squirrel monkey. J Neurophysiol 51:1236–1256
Goldberg JM, Highstein SM, Moschovakis AK, Fernandez C (1987) Inputs from regularly and irregularly discharging vestibular nerve afferents to secondary neurons in the vestibular nuclei of the squirrel monkey. I. An electrophysiological analysis. J Neurophysiol 58:700–718
Halliwell JV (1990) K+ channels in the central nervous system. In: Cook NS (eds) Potassium channels, structure, classification, function and therapeutic potential. John Wiley & Sons, NewYork, pp 348–381
Highstein SM, Goldberg JM, Moschovakis AK, Fernandez C (1987) Inputs from regularly and irregularly discharging ves- tibular nerve afferents to secondary neurons in the vestibular nuclei of the squirrel monkey. II. Correlation with output pathways of secondary neurons. J Neurophysiol 58:719–738
Llinás R, Sugimori M (1980) Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices. J Physiol (Lond) 305:171–195
Llinás R, Yarom Y (1981) Electrophysiology of mammalian inferior olivary neurones in vitro. Different types of voltage-dependent ionic conductances. J Physiol (Lond) 315:549–567
Llinás R (1988) The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. Science 242:1654–1664
Orlovsky GN (1972) Activity of vestibulospinal neurons during locomotion. Brain Res 46:85–98
Sah P, Hestrin S, Nicoll RA (1989) Tonic activation of NMDA receptors by ambient glutamate enhances excitability of neurons. Science 246:815–818
Serafin M, de Waele C, Khateb A, Vidal PP, Mühlethaler M (1991b) Medial vestibular nucleus in the guinea-pig. II. Ionic basis of the intrinsic membrane properties in brainstem slices. Exp Brain Res 84:426–433
Serafin M, Mühlethaler M (1989) Electrophysiological study of vestibular nuclei neurons in vitro. Experientia 45: A13
Serafin M, Vidal PP, de Waele C, Khateb A, Mühlethaler M (1989) Burst firing of medial vestibular nuclei neurones in vitro. Soc Neurosci Abstr 15:452
Serafin M, Khateb A, de Waele C, Vidal PP, Mühlethaler M (1990) Low threshold calcium spikes in medial vestibular nuclei neurones in vitro: a role in the generation of the vestibular nystagmus quick phase in vivo? Exp Brain Res 82:187–190
Wilson VJ, Melvill Jones G (1979) Mammalian vestibular physiology. Plenum Press, New York
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Serafin, M., de Waele, C., Khateb, A. et al. Medial vestibular nucleus in the guinea-pig. Exp Brain Res 84, 417–425 (1991). https://doi.org/10.1007/BF00231464
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DOI: https://doi.org/10.1007/BF00231464