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Non-coordinate expression of collagen mRNAs during carbon monoxide-induced cardiac hypertrophy

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Abstract

Collagen gene expression during volume overload-induced cardiac hypertrophy was investigated in adult male rats. Hypertrophy of the left ventricle (22%) and right ventricle (37%) occurred following 27 days continuous exposure to 700 ppm carbon monoxide; hematocrit increased nearly 47%. To examine potential cellular and molecular control of restructuring in the heart, we investigated the expression of two specific procollagen mRNAs for collagen types which have different structural-functional roles [Type I (alpha-1) & Type IV]. Type I (interstitial) mRNA levels increased at least 100% relative to controls within 3 days of initial exposure to 700ppm CO, then declined afterwards; type IV(basement membrane) mRNA levels increased more modestly at first, and increased further afterwards. The ratio of type I/type IV RNA's also increased initially, then later declined, with the greatest differences in the relative responses of type I and IV mRNAs seen in the right ventricle. These data suggest that types I and IV collagen mRNA expression is not coordinately expressed during this type of volume overload-induced hypertrophy in rat heart.

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Authors and Affiliations

  1. Wayne State University School of Medicine, 48201, Detroit, MI, USA

    David G. Penney

  2. The University of Alabama at Birmingham, 35294, Birmingham, AL, USA

    Lawrence B. Bugaisky

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  1. David G. Penney
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  2. Lawrence B. Bugaisky
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Penney, D.G., Bugaisky, L.B. Non-coordinate expression of collagen mRNAs during carbon monoxide-induced cardiac hypertrophy. Mol Cell Biochem 109, 37–41 (1992). https://doi.org/10.1007/BF00230871

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  • DOI: https://doi.org/10.1007/BF00230871

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