Summary
A description is given of the distribution of peroxidatic (PO) activity in murine monocytes of blood and peritoneal cavity, and in murine macrophages residing in the unstimulated peritoneal cavity as well as in liver, spleen, bone marrow, and small intestine. In the monocytes, PO activity is restricted to some of the cytoplasmic granules; in the tissue (or resident) macrophages present in peritoneal cavity, liver, spleen, and small intestine, the PO activity is located in the nuclear envelope and the rough endoplasmic reticulum. Macrophages in the bone marrow are PO-negative. In the spleen and bone marrow, reticulum cells show PO activity in the nuclear envelope and the RER.
Transitional forms between monocytes and tissue macrophages were not observed.
Similar content being viewed by others
References
Berman, I.: The ultrastructure of erythroblastic islands and reticular cells in mouse bone marrow. J. Ultrastruct. Res. 17, 291–314 (1967)
Bissel, D.M., Hammakar, L., Schmid, R.: Liver sinusoidal cells. Identification of a subpopulation for erythrocyte catabolism. J. Cell Biol. 54, 107–119 (1972)
Bodel, P.T., Nichols, B.A., Bainton, D.F.: Appearance of peroxidase reactivity within the rough endoplasmic reticulum of blood monocytes after surface adherence. J. exp. Med. 145, 264–274 (1977)
Boyum, A.: Separation of blood leucocytes, granulocytes and lymphocytes. Tiss. Antigens. 4, 269–275 (1974)
Breton-Gorius, J., Reyes, F.: Ultrastructure of human bone marrow cell maturation. Int. Rev. Cytol. 46, 251–320 (1976)
Cavallo, T.: Cytochemical localization of endogeneous peroxidase activity in renal medullary collecting tubules and papillary mucosa of the rat. Lab. Invest. 34, 223–228 (1976)
Cline, M.J.: Monocytes and macrophages: differentiation and function. In: Formation and destruction of blood cells (Greenwalt, T.J., Jamieson, G.A., eds.), pp. 222–239. Philadelphia and Toronto: Lippincott 1970
Cohn, Z.A.: The structure and function of monocytes and macrophages. Adv. Immunol. 9, 163–214 (1968)
Daems, W.Th.: Erythroclasia in lysosomes of mouse spleen macrophages. 4th Eur. Reg. Conf. on Electron Microscopy, Rome, pp. 237–238 (1968)
Daems, W.Th., Brederoo, P.: Electron microscopical studies on the structure, phagocytic properties and peroxidatic activity of resident and exudate peritoneal macrophages in the guinea pig. Z. Zellforsch. 144, 247–297 (1973)
Daems, W.Th., Gemund, J.J. van, Vio, P.M.A., Willighagen, R.J.G., den Tandt, W.R.: The use of intestinal suction-biopsy material for the study of lysosomal storage diseases. In: Lysosomes and storage diseases (Hers, H.G., van Hoof, F., eds.), pp. 575–598. New York-London: Academic Press 1973
Daems, W.Th., Koerten, H.K.: The effect of various stimuli on the cellular composition of peritoneal exudates in the mouse. Cell and Tiss. Res., in press (1978)
Daems, W.Th., Koerten, H.K., Soranzo, M.R.: Differences between monocyte-derived and tissue macrophages. In: The reticuloendothelial system in health and disease: Functions and characteristics (Reichard, S.M., Escobar, M.R., Friedman, H., eds.), pp. 27–40. New York-London: Plenum Press 1976
Daems, W.Th., Wisse, E., Brederoo, P.: Electron microscopy of the vacuolar apparatus. In: Lysosomes in biology and pathology (Dingle, J.T., Fell, H.B., eds.), Vol. I., pp. 64–112. Amsterdam-London: North-Holland Publ. Comp. 1969
Daems, W.Th., Wisse, E., Brederoo, P., Emeis, J.J.: Peroxidatic activity in monocytes and macrophages. In: Mononuclear phagocytes in immunity, infection and pathology (van Furth, R., ed.), pp. 57–77. Oxford: Blackwell Sci. Publ. 1975
Deane, H.W.: Some electron microscopic observations on the lamina propria of the gut, with comments on the close association of macrophages, plasma cells and eosinophils. Anat. Rec. 149, 453–474 (1964)
Ebert, R.H., Florey, H.W.: The extravascular development of the monocyte observed in vivo. Brit. J. exp. Path. 20, 342–356 (1939)
Fahimi, H.D.: The fine structural localization of endogeneous and exogeneous peroxidase activity in Kupffer cells of rat liver. J. Cell Biol. 47, 247–262 (1970)
Fedorko, M.E.: Morphological and functional characteristics of bone marrow macrophages from Imferon-treated mice. Blood 45, 435–449 (1975)
Fedorko, M.E., Hirsch, J.G.: Structure of monocytes and macrophages. Sem. Haemat. 7, 109–124 (1970)
Furth, R. van: Origin and kinetics of mononuclear phagocytes. Ann. N.Y. Acad. Sci. 278, 161–175 (1976)
Furth, R. van, Cohn, Z.A., Hirsch, J.G., Humphrey, J. H., Spector, W.G., Langevoort, H.L.: The mononuclear phagocyte system: A new classification of macrophages, monocytes and their precursor cells. Bull. World Hlth Org. 46, 845–852 (1972)
Furth, R. van, Fedorko, M.E.: Ultrastructure of mouse mononuclear phagocytes in bone marrow colonies grown in vitro. Lab. Invest. 34, 440–450 (1976)
Gerrard, J.M., White, J.G., Rao, G.H.R., Townsend, W.: Localization of platelet prostaglandin production in the platelet dense tubular system. Amer. J. Path. 83, 283–293 (1976)
Goud, T.J.L.M., Schotte, C., Furth, R. van: Identification and characterization of the monoblast in mononuclear phagocyte colonies grown in vitro. J. exp. Med. 142, 1180–1199 (1975)
Hoefsmit, E.Ch.M.: Mononuclear phagocytes, reticulum cells and dendrite cells in lymphoid tissue. In: Mononuclear phagocytes in immunity, infection and pathology (Furth, R. van, ed.), pp. 129–146. Oxford-London-Edinburgh-Melbourne: Blackwell Sci. Publ. 1975
Janszen, F.H.A., Nugteren, D.H.: Histochemical localization of prostaglandin synthetase. Histochem. 27, 159–164 (1971)
Kaplow, L.S.: Simplified myeloperoxidase stain using benzidine dihydrochloride. Blood 26, 215–219 (1965)
Klebanoff, S.J., Hamon, B.: Antimicrobial systems of mononuclear phagocytes. In: Mononuclear phagocytes in immunity, infection and pathology (Furth, R. van, ed.), pp. 507–529. Oxford-London-Edinburgh-Melbourne: Blackwell Sci. Publ. 1975
Kojima, M.: Macrophages, reticuloendothelial system and mononuclear phagocyte system. Rec. Adv. in RES Research 16, in press (1977)
Mims, C.A.: The peritoneal macrophages of mice. Brit. J. exp. Path. 45, 37–43 (1964)
Naito, M., Wisse, E.: Observations on the fine structure, cytochemistry and kinetics of sinusoid lining cells in neonatal and fetal rat liver. Ultramicroscopy 2, 131 (1976)
Nichols, B.A., Bainton, D.F.: Ultrastructure and cytochemistry of mononuclear phagocytes. In: Mononuclear phagocytes in immunity, infection and pathology (Furth, R. van, ed.), pp. 17–55. Oxford: Blackwell Sci. Publ. 1975
Ogawa, T., Koerten, H.K., Daems, W.Th.: Peroxidatic activity in mouse tissue macrophages. Ultramicroscopy 2, 132 (1976)
Orenstein, J.M., Shelton, E.: Surface topography of leucocytes in situ: Cells of mouse peritoneal milky spots. Exp. molec. Path. 24, 415–423 (1976)
Ploeg, M. van der, Streefkerk, J.G., Daems, W.Th., Brederoo, P.: Quantitative aspects of cytochemical peroxidase reaction with 3,3′-diaminobenzidine and 5,6-dihydroxy indole as substrates. In: Electron microscopy and cytochemistry (Wisse, E., Daems, W. Th., Molenaar, I., van Duijn, P., eds.), Proc. 2nd Int. Symp., Drienerloo, The Netherlands, pp. 123–126. Amsterdam: North-Holland Publ. Comp. 1974
Rhee, H.J. van der, Brederoo, P., Daems, W.Th.: In vivo adherence of monocytes does not lead to the appearance of peroxidatic activity in the rough endoplasmic reticulum. Cell Biol. Int. Rep. 2, 99–102 (1978)
Rhee, H.J. van der, Winter, C.P.M. de, Daems, W.Th.: Fine structure and peroxidatic activity of rat blood monocytes. Cell and Tiss. Res. 185, 1–16 (1977 a)
Roels, F., Wisse, E., Prest, B.D. de Meulen, J. van der: Cytochemical discrimination between catalases and peroxidases using diaminobenzidine. Histochem. 41, 281–312 (1975)
Roos, B.: Macrophagen: Herkunft, Entwicklung, und Funktion. In: Handbuch der allgemeinen Pathologie, Bd VII/3 (Studer, A., Cottier, H., Hrsg.), S. 1–128. Berlin-Heidelberg-New York: Springer 1970
Shands, J.W., Axelrod, B.J.: Mouse peritoneal macrophages: tritiated thymidine labeling and cell kinetics. J. reticuloendoth. Soc. 21, 69–76 (1977)
Simmons, S.R., Karnovsky, M.L.: Iodinating ability of various leukocytes and their bactericidal activity. J. exp. Med. 138, 44–63 (1973)
Simon, G.T., Burke, J.S.: Electron microscopy of the spleen. III Erythro-leucophagocytosis. Amer. J. Path. 58, 451–470 (1970)
Soranzo, M.R., Koerten, H.K., Daems, W.Th.: Peroxidatic activity and morphometric analysis of alveolar macrophages in the guinea pig. J. reticuloendoth. Soc. in press (1978)
Sutton, J.S.: Ultrastructural aspects of in vitro development of monocytes into macrophages, epitheloid cells and multi-nucleated giant cells. Nat. Cancer Inst. Monogr. 26, 71–141 (1967)
Volkman, A.: The origin and fate of the monocyte. In: Aspects of inflammation (Jensen, K.G., Killmann, S.A., eds.) Ser. Haematol. III/2, 62–92 (1970)
Volkman, A.: A current perspective of monocytopoiesis. Curr. Top. Pathol. 54, 76–94 (1971)
Volkman, A.: Disparity in origin of mononuclear phagocyte populations. J. reticuloendoth. Soc. 19, 249–268 (1976)
Walker, W.S.: Functional heterogeneity of macrophages. In: Immunobiology of the macrophages (Nelson, D.S., ed.), pp. 91–108. New York: Academic Press 1976
Watanabe, K.S., Masubuchi, S., Kageyama, K.: Ultrastructural localization of peroxidase in mononuclear cells from the peritoneal cavity, blood, bone marrow and omentum, with a special reference to the origin of peritoneal macrophages. In: Rec. Adv. RES Research, 11, 120–147 (1973)
Wisse, E., Giphart, M., Meulen, J. van der, Roels, F., Emeis, J.J. Daems, W.Th.: Peroxidatic activity in bacteria-phagocytizing Kupffer cells, demonstrated by a new method: perfusion incubation. In: Electron Microscopy 1972. Proc. 5th Eur. Congress, Manchester 1972 (Cosslett, V.E., pres.), pp. 272–273. London-Bristol: The Inst. of Physics 1972
Wisse, E.: Kupffer cell reaction in rat liver under various conditions as observed in the electron microscope. J. Ultrastruct. Res. 46, 499–520 (1974)
Wisse, E.: Ultrastructure and function of Kupffer cells and other sinusoidal cells in the liver. In: Kupffer cells and other sinusoidal cells (Wisse, E., Knook, D.L., eds.), pp. 33–60. Amsterdam: Elsevier 1977
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ogawa, T., Koerten, H.K. & Daems, W.T. Peroxidatic activity in monocytes and tissue macrophages of mice. Cell Tissue Res. 188, 361–373 (1978). https://doi.org/10.1007/BF00219778
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00219778