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Chromosome 1 in human colorectal tumors

Cytogenetic research on structural changes and their significance

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Summary

The significance of short and long arm anomalies of chromosome 1 was investigated in 55 colorectal tumors comprising 41 carcinomas and 14 adenomas. The tumors were at various stages of transformation from adenoma to carcinoma. Our investigation was prompted by the observation of a p32-pter deletion on the short arm of chromosome 1 in a case of benign tubulovillous adenoma with mild dysplasia, as well as by frequent reports that chromosome 1 is involved in many neoplastic processes. Long arm anomalies were found in seven of the 41 carcinomas, six of which were in stage B2, and short arm anomalies in ten carcinomas at various stages. Three of the adenomas exhibited chromosome 1 anomalies, which in one case comprised a 1p32-pter deletion only. Overall, short arm anomalies especially concerned the p32–36 region. These results suggest that the cytogenetic anomalies respectively located on the short and long arms of chromosome 1 should be considered separately. Damage to the long arm might constitute a late non-specific event, whereas damage to the p32-pter region of the short arm might be involved in triggering colorectal tumor development.

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Authors and Affiliations

  1. Laboratoire d'Histologie, Biologie Cellulaire, et Cytogénétique, UER X. Bichat, 16, Rue Henri Huchard, F-75018, Paris, France

    Marie-Hélène Couturier-Turpin & Yvonne Poirier

  2. Groupe de Recherche en Pathologie Digestive, Hôpital Cochin, 27, Rue du Faubourg Saint-Jacques, F-75014, Paris, France

    Catherine Esnous & Daniel Couturier

  3. Laboratoire d'Anatomie Pathologique, Hôpital Cochin, 27, Rue du Faubourg Saint-Jacques, F-75014, Paris, France

    Albert Louvel

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  1. Marie-Hélène Couturier-Turpin
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  2. Catherine Esnous
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  3. Albert Louvel
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  4. Yvonne Poirier
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  5. Daniel Couturier
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Couturier-Turpin, MH., Esnous, C., Louvel, A. et al. Chromosome 1 in human colorectal tumors. Hum Genet 88, 431–438 (1992). https://doi.org/10.1007/BF00215678

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  • DOI: https://doi.org/10.1007/BF00215678

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