Skip to main content
Log in

Type III collagen in normal human articular cartilage

  • Papers
  • Published:
The Histochemical Journal Aims and scope Submit manuscript

Summary

Type III collagen in normal human articular cartilage has been detected biochemically and its location in a diffuse area around the chondrocytes demonstrated by immunofluorescence. It can be found pericellularly throughout the depth of the cartilage and is evident in specimens ranging in age from 17 to 81 years.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Aigner, T., Bertling, W., Stob, H., Weseloh, G. & Von DerMark, K. (1993) Independent expression of fibril-forming collagens I, II and III in chondrocytes of human osteoarthritic cartilage. J. Clin. Invest. 91, 829–37.

    Google Scholar 

  • Duance, V. C. (1983) Surface of articular cartilage: immunohistological studies. Cell. Biochem. Funct. 1, 143–4.

    Google Scholar 

  • Duance, V. C. & Wotton, S. F. (1991) Changes in the distribution of mammalian cartilage collagens with age. Biochem. Trans. 19, 376S.

    Google Scholar 

  • Duance, V. D., Wotton, S. F., Voyle, C. A. & Bailey, A. J. (1984) Isolation and characterisation of the precursor of type M collagen. Biochem. J. 221, 885–9.

    Google Scholar 

  • Eyre, D. R., Apone, S., Wu, J. J., Ericsson, L. H. & Walsh, K. A. (1987a) Collagen type IX: evidence for covalent linkages to type II collagen in cartilage. FEBS Lett. 220, 337–41.

    Google Scholar 

  • Eyre, D. R., Wu, J. J. & Apone, S. (1987b) A growing family of collagens in articular cartilage: identification of five genetically distinct types. J. Rheumatol. 14, 25–7.

    Google Scholar 

  • Eyre, D. R., Wu, J. J. & Woods, P. (1992) Cartilage-specific collagens: structural studies. In Articular Cartilage and Osteoarthritis (edited by Kuettner, K. E., Schleyerbach, R., Peyron, J. G. & Hascall, V. C.) pp. 119–31. New York: Raven Press.

    Google Scholar 

  • Fleischmajer, R., Timpl, R., Tuderman, L., Raisher, L., Wiestner, M., Perlish, J. S. & Graves, P. N. (1981) Ultrastructural identification of extension aminopropeptides of type I and III collagens in human skin. Proc. Natl Acad. Sci. USA 78, 7380–4.

    Google Scholar 

  • Furuto, D. K., Gay, R. E., Stewart, T. E., Miller, E. J. & Gay, S. (1991) Immunolocalisation of type V and type XI collagen in cartilage using monoclonal antibodies. Matrix 11, 144–9.

    Google Scholar 

  • Gannon, J. M., Walker, G., Fischer, M., Carpenter, R., Thompson, R. C. & Oegema, T. R. (1991) Localisation of type X collagen in canine growth plate and adult canine articular cartilage. J. Orthop. Res. 9, 485–94.

    Google Scholar 

  • Gay, S. & Miller, E. J. (1978) In Collagen in the Physiology and Pathology of Connective Tissue (edited by) pp. 6–7, 105. Stuttgart, New York: Gustav Fischer Verlag.

    Google Scholar 

  • Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680–5.

    Google Scholar 

  • Mayne, R. (1986) Collagen types in cartilage. In Articular Cartilage Biochemistry (edited by Kuettner, K. E., Schleyerbach, R. & Hascall, V. C.) pp. 23–38. New York: Raven Press.

    Google Scholar 

  • Poole, C. A., Ayad, S. & Schofield, J. R. (1988) Chondrons from articular cartilage: immunolocalisation of type VI collagen in the pericellular capsule of isolated canine tibial chondrons. J. Cell Sci. 90, 635–43.

    Google Scholar 

  • Roberts, S., Menage, J., Duance, V. & Wotton, S. (1991a) Type III collagen in the intervertebral disc. Histochem. J. 23, 503–8.

    Google Scholar 

  • Roberts, S., Menage, J., Duance, V., Wotton, S. & Ayad, S. (1991b) Collagen types around the cells of the intervertebral disc and cartilage end plate: an immunolocalisation study. Spine 16, 1030–8.

    Google Scholar 

  • Towbin, H., Stachlin, T. & Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets; procedure and some applications. Proc. Natl Acad. Sci. USA 76, 4350–4.

    Google Scholar 

  • Wardale, R. J. & Duance, V. C. (1993) Quantification and immunolocalisation of porcine articular and growth plate collagens. J. Cell Sci. 105, 975–84.

    Google Scholar 

  • Wotton, S. F., Duance, V. C. & Fryer, P. R. (1988) Type IX collagen: a possible function in articular cartilage. FEBS Lett. 234, 79–82.

    Google Scholar 

  • Wotton, S. F., Jeacocke, R. E., Maciewicz, R. A., Wardale, R. J. & Duance, V. C. (1991) The application of scanning microscopy in cartilage research. Histochem. J. 23, 328–35.

    Google Scholar 

  • Woessner, J. F. (1976) In The Methodology of Connective Tissue Research (edited by Hall, D. A.), p. 227. Oxford: Johnson-Bruvvers.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wotton, S.F., Duance, V.C. Type III collagen in normal human articular cartilage. Histochem J 26, 412–416 (1994). https://doi.org/10.1007/BF00160053

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00160053

Keywords

Navigation