Abstract
Thirty-five patients with long-standing deep stromal herpes simplex keratitis were treated with 3% acyclovir ointment and corticosteroids. All patients were cured in 2 to 4 weeks, independent of both the duration of the keratitis before acyclovir therapy and the previous antiviral medication. Corticosteroids in tapering dosages had to be continued for many months after healing to prevent recurrence of stromal corneal oedema; recurrences could not be prevented by acyclovir therapy. No serious side-effects of acyclovir were noted.
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Bauer DJ, Collins P. Tucker WE and Macklin AW (1979) Treatment of experimental herpes simplex keratitis. Brit J Ophthal 63:429–435
Charpentier B, Lefèvre JJA, Verneau A, Lebuisson DA and Fries D (1980) Kératoconjonctivite herpétique grave après transplantation rénale. Nouv Presse Méd 9:255–256
Colin J, Chastel C, Quillien MC and Renard G (1981) Traitement comparé de la kératite herpétique expérimentale du lapin par l'idoxuridine et l'acyclovir: Correlations clinique, virologiques et histopathologiques. J Fr Ophtal 4:33–44
Colin J, Tournoux A, Chastel C and Renard G (1981) Kératite herpétique superficielle. Traitement comparatif en double insu par acyclovir et idoxuridine. Nouv Presse Méd 10:2969–2975
Collum LMT and Benedict-Smith A (1981) Acyclovir (Zovirax) in herpes simplex In: Herpetische Augenerkrankungen, ed: R Sundmacher. München, Bergmann, pp 323–327
Collum LMT, Benedict-Smith A and Hillary IB (1980) Randomised double blind trial of acyclovir and idoxuridine in dendritic corneal ulceration. Brit J Ophthal 64:766–769
Collum LMT, Logan P, Hillary IB and Ravenscroft T (1982) Acyclovir in herpes keratitis. Amer J Med (Acyclovir Symposium) 73:290–293
Coster DJ, Wilhelmus KR, Michaud R and Jones BR (1980) A comparison of acyclovir and idoxuridine as treatment for ulcerative herpetic keratitis. Brit J Ophthal 64:763–765
Desbordes IM, Thompson P, Giraud J, Denis J and Pouliquen Y (1981) Antiviraux et cicatrisation de l'épithelium cornéen. Une étude expérimentale sur le lapin. J Fr Ophtal 4:797–804
Falcon MG and Jones BR (1979) Acycloguanosine: antiviral activity in the rabbit cornea. Brit J Ophthal 63:422–424
Gundersen T (1936) Herpes corneae with special reference to its treatment with strong solution of iodine. Arch Ophthal 15:225–249
Jones BR, Fison PN, Cobo LM, Coster DJ, Thompson GM and Falcon MG (1980) Efficacy of acycloguanosine (Wellcome 248U) against herpes simplex corneal ulcers. Lancet I:243–244
Kaufman HE (1978) Herpetic Keratitis. Proctor Lecture. Invest Ophthal Vis Sci 17:941–957
Kaufman HE (1981) Animal models in the development of antiviral therapy. In: Herpetische Augenerkrankungen, ed: R Sundmacher. München, Bergmann, pp 229–236
Kaufman HE, Martola EL and Dohlman CH (1963) Herpes simplex treatment with IDU and corticosteroids. Trans Amer Acad Ophthal Otolaryng 67:695–701
Kaufman HE, Varnell ED, Centifanto YM and Rheinstrom SD (1978) Effect of 9-(2-hydroxyethoxymethyl)guanine on herpesvirus-induced keratitis and iritis in rabbits. Antimicrobial Agents and Chemotherapy 4:842–845
La Lau C, Oosterhuis JA, Versteeg J, Van Rij G, Renardel de Lavalette JGC, Craandijk A, Lamers WRMJ and Mierlobensteyn Th (1981) Aciclovir and trifluorothymidine in herpetic keratitis. Preliminary report of a multicentered trial. Docum Ophthal 50:287–290
Lass JH, Pavan-Langston D and Park N-H (1979) Aciclovir and corneal wound healing. Amer J Ophthal 88:102–108.
McGill J and Tormey P (1982) Use of acyclovir in herpetic ocular infection. Amer J Med (Acyclovir Symposium) 73:286–289
McGill J, Tormey P and Walker C (1981) The clinical use of acyclovir in the treatment of herpes simplex corneal ulceration. In: Herpetische Augenerkrankungen, ed: R. Sundmacher. München, Bergmann, pp 319–322
Nesburn AB and Trousdale MD (1981) Treatment of acute and chronic ocular herpes infection with acyclovir. In: Herpetische Augenerkrankungen, ed: R Sundmacher. München, Bergmann, pp 309–314
O'Brien WJ, Clough DW, Geroski DH and Edelhauser HF (1981) Effects of nucleoside antivirals and their metabolites on the corneal endothelium. Curr Eye Res 1:243–248
Oosterhuis JA, Versteeg J, Kruit PJ and Postma BH (1980) Aciclovir treatment in experimental herpetic keratitis in rabbits. Ophthal Res 12:38–44
Pavan-Langston D and Abelson MB (1977) The role of steroids in ocular herpes. In: Controversy in ophthalmology, eds: RJ Brockhurst a.o. Philadelphia, Saunders, pp 438–449
Pavan-Langston D, Campbell R and Lass J (1978) Acyclic antimetabolite therapy of experimental herpes simplex keratitis. Amer J Ophthal 86:618–623
Pavan-Langston D, Lass J, Hettinger M and Udell I (1981) Acyclovir and vidarabine in the treatment of ulcerative herpes simplex keratitis. Amer J Ophthal 92:829–835
Pokier R, Kingham JD and Hutcherson S (1982) Human aqueous penetration of topically applied acyclovir ophthalmic ointment. Amer J Med (Acyclovir Symposium) 73:393
Shiota H, Inouie S and Yamane S (1979) Efficacy of acycloguanosine against herpetic ulcers in rabbit cornea. Brit J Ophthal 63:425–428
Shiota H, Ogawa T and Yamane S (1981) Studies of Acyclovir and Ara-AMP against herpetic keratitis in rabbits. In: Herpetische Augenerkrankungen, ed: R Sundmacher. München, Bergmann, pp 315–318
Sundmacher R and Neumann-Haefelin D (1979) Herpes-simplex-Virus-Isolierung aus Kammerwasser bei fokaler Iritis, Endotheliitis und langdauernder Keratitis disciformis mit Sekundärglaukom. Klin Mbl Augenheilk 175:488–501
Taylor JL and O'Brien WJ (1981) The cytotoxicity of nucleoside antivirals to epithelial cells of ocukr origin. In: Herpetische Augenerkrankungen, ed: R Sundmacher. München, Bergmann, pp 269–276
Tormey P, McGill Jand Walker C (1981) Use of acyclovir in herpes simplex corneal ulcers. Trans Ophthal Soc UK 101:6–8
Trousdale MD, Dunkel EC and Nesburn AB (1980) Effect of acyclovir on acute and latent herpes simplex virus infections in the rabbit. Invest Ophthal Vis Sci 19:1336–1341
Varnell ED and Kaufman HE (1981) Antiviral agents in experimental herpetic stromal disease. In: Herpetische Augenerkrankungen, ed: R Sundmacher. München, Bergmann, pp 303–308
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Oosterhuis, J.A., Van Ganswijk, R. & Versteeg, J. Acyclovir treatment in stromal herpetic keratitis. Doc Ophthalmol 56, 81–88 (1983). https://doi.org/10.1007/BF00154713
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DOI: https://doi.org/10.1007/BF00154713