Abstract
A rare case of primary cerebral zygomycosis in an Italian drug addict is described. The diagnosis was based on the histologic detection of broad, aseptate, hyaline mycelium in fluid aspirated from a brain mass detected by computerized axial tomography. The zygomycete isolated from the clinical specimen was identified as Rhizopus arrhizus var arrhizus. The patient had no known predisposing condition that would have suppressed his immunological defenses. Once the diagnosis was established, treatment with amphotericin B was initiated, but the patient died during the first day of treatment.
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References
AielloL., DeanD.F. and IrwinR.S. (1976): The zysomycete Saksenaea vasiformis as a pathogen of humans with a critical review of the etiology of zygomycosis. - Mycologia, 68: 52–62.
BakerR.D. (1971): Mucormycosis. In: The Pathologic Anatomy of Mycoses. Baker R.D. ed. Springer-Verlag, Berlin, pg. 832.
CamerlynckP., RifleG., ScholerH., JustraboE., ViryE., GuillaumieJ. and GeninR. (1977): Mucornycose (phycomycose) cerebrate chez un transplante renal. - Bull. Soc. Fr. Mycol. Med., 6: 239–241.
ChandlerF.W., KaplanW. and AjelloL. (1980): Zygomycosis. In: Color Atlas and Text of the Histopathology of Mycotic Diseases, Year Book Medical Publishers, Chicago, pg. 122.
EllisJ.J. (1985): Species and varieties in the Rhizopus arrhizus — Rhizopus oryzae group as indicated by their DNA complementarity. - Mycologia, 77: 243–247.
EschardJ.P., PoynardJ.P., JanodyD., RicardY., DieboldM.D., GariM. and LeuteneggerM. (1984): Mucormycose cutanee chez une diabetique. Problemes diagnostiques et therapeutiques. - Rev. Med. Interne, 5: 298–302.
FerryA.P. (1961): Cerebral mucormycosis (phycomycosis). Ocular findings and review of the literature.- Surv. Ophthalmol., 6: 1–24.
Fetchick R.J., Rinaldi M.G. and Sum S.H. (1986): Zygomyoosis due to Mucor circinelloides, a rare agent of fungal diseases. Abstracts Annual Meeting, Amer. Sac. Microbiol. — 1986, pg, 404, F-42.
HalwegH. and PodsiadloB. (1986): Rhizopus oryzae jako przyczyna grzybicy zatok przynosowych. -Acta Mycologica, 22: 43–48.
HamilR., OneyL.A. and CraneL.R. (1983): Successful therapy for rhinocerebral mucormycosis with associated bilateral brain abscesses. - Arch. Intern. Med., 143: 581–583.
HutchinsonJ.A., KingD.S. and NickersonM.A. (1972): Studies on temperature requirements, odor production and zygospore wall undulation of the genus Basidiobolus. - Mycologia, 64: 467–474.
KaufmanL. and ReissE. (1985): Serodiagnosis of fungal diseases. In: Manual of Clinical Microbiology, Lennette E.H., Balows A., Hausler W.J. & Shadomy J.H., eds. American Society for Microbiology, Washington, D.C., p. 924.
KingD.S. and JongS.C. (1976): Identity of the etiological agent of the first deep entomophthoraceous infection of mean in the United States. -Mycologia, 68: 181–183.
KrasinskiK., HolzmanR.S., HannaB., GrecoA., GraffM. and BhogalM. (1985): Nosocomial fungal infection during hospital renovation. - Infect. Control, 6: 278–282.
LehrerR.I., HowardD.H., SypherdP.S., EdwardsJ.E., SegalG.P. and WinstonD.J. (1980): Mucormycosis.- Ann. Intern. Med., 93: 93–108.
MarchevskyA.M., BottoneE.J., GellerS.A. and CigerD.K. (1980): The changing spectrum of disease, etiology, and diagnosis of mucormycosis. - Human Pathology, 11: 457–464.
McBrideR.A., CorsonJ.M. and DamminG.J. (1960): Mucormycosis. Two cases of disseminated disease with cultural identification of Rhizopus: Review of literature. - Am. J. Med., 28: 832–846.
McGinnisM.R. (1980): Laboratory Handbook of Medical Mycology. Academic Press, New York.
MeyerR.D. and ArmstrongD. (1973): Mucormycosis changing status. - CRC Crit. Rev. Clin. Lab. Sci., 4: 421–451.
MeyerR.D., RosenP. and ArmstrongD. (1972): Phycomycosis complicating leukemia and lymphoma. -Ann. Intern. Med., 77: 871–879.
Palacio HernanzA. Del, Delgado VazquezR., Bernaldo De QuirosJ.C., Perez RivallaA. and Martin-Rabadan CaballeroP. (1987): Cinco cases de zygo-micosis en un hospital general. Estudio epidemiologico de un possible origin nosocomial. - Rev. Iberica Micologia, 4: 135–148.
PierceP.F., SolomonS.L., KaufmanL., GaragusiV.F., ParkerR.H. and AielloL. (1982): Zygomycetes brain abscesses in narcotic addicts with serological diagnosis. - J. Am. Med. Assoc., 248: 2881–2892.
PileriS., BazzocchiF., GrigioniF.W., MartinelliG., MazzacuratiA., BaccaraniM. and MazzoniA. (1978): Leucemie e infezioni micotiche: Presentazione di un caso di ficomicosi. - Patologica, 70: 639–650.
RothburnM.M., ChambersD.K., RobertsC. and DownieR.T.G. (1986): Cutaneous mucormycosis: A rare cause of leg ulceration. - J. Infection, 13: 175–178.
SarfatiC., LevergerG., BadilletG. and LariviereM. (1985): Boule fongigue urinaire a mucormycose chez un enfant immunodeprime. - Bull. Soc. Fr. Mycol. Med., 14: 289–292.
SchipperM.A.A. (1978): On the genera Rhizomucor and Parasitella. pp. 53–71. Studies in Mycology, No. 17. Centraalbureau voor Schimmelcultures, Baarn, The Netherlands.
SchipperM.A.A. (1984): A revision of the genus Rhizopus. In: Studies in Mycology, No. 25. Centraalbureau voor Schimmelcutures, Baarn, The Netherlands.
ScholerH.J., MullerE. and SchipperM.A.A. (1983): Mucorales, pp. 9–59. In: D.H. Howard (ed.) Fungi Pathogenic for Humans and Animals. Vol. A. Marcel Dekker, Inc., New York.
StraatsmaB.R., ZimmermanL.E. and GassJ.D.M. (1962): Phycomycosis. A clinicopathologic study of fifty-one cases. - Lab. Invest., 11: 963–985.
VonlanthenM., ThielG., BrunnerF., HarderF., KellerM., StoecklinM., OhnackerH., JacquesW. and PodvinecM. (1977): Mucormycose craniale chez un transplante renal. - Schweiz. Med. Wschr., 107: 1784–1786.
WeidenM.A., SteinbronnK.K., PadhyeA.A., AjelloL. and ChandlerF.W. (1985): Zygomyoosis caused by Apophysomyces elegans. - J. Clin. Microbiol. 22: 522–526.
WeitzmanI. and CristM.Y. (1979): Studies with clinical isolates of Cunninghamella. I. Mating behavior. - Mycologia, 71: 1024–1033.
WeitzmanI. and CristM.Y. (1980): Studies with clinical isolates of Cunninghamella. II. Physiological and morphological studies. - Mycologia, 82: 661–669.
WetliC.V., WeissS.D., ClearyT.J. and GyoriE. (1984): Fungal cerebrities from intravenous drug abuse. - J. Forensic Sci., 29: 260–268.
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Oliveri, S., Cammarata, E., Augello, G. et al. Rhizopus arrhizus in Italy as the causative agent of primary cerebral zygomycosis in a drug addict. Eur J Epidemiol 4, 284–288 (1988). https://doi.org/10.1007/BF00148911
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DOI: https://doi.org/10.1007/BF00148911