Riassunto
Uno studio sistematico mirante ad accertare la radiosensibilità cellulare nelle varie zone dell'epitelio lenticolare è stato condotto nel ratto sottoposto ad irradiazione del solo occhio destro con 1000 r.
La zona post-equatoriale e quella equatoriale dell'epitelio sono state riscontrate particolarmente radiosensibili, in rapporto alla attività differenziativa e proliferativa delle cellule in queste zone.
Cellule a nucleo gigante e mitosi a numero probabilmente poliploide di cromosomi, sono state riscontrate corne effetto tardivo della irradiazione.
I reperti ottenuti vengono analizzati e discussi.
Résumé
Une étude systématique visant à établir la radiosensibilité cellulaire dans les diverses zones de l'épithélium du cristallin, a été effectuée sur le rat soumis à une irradiation de 1000 r au niveau de l'oeil droit.
La zone post-équatoriale et celle équatoriale de l'épithélium ont montré une radiosensibilité particulière, celle-ci est en rapport avec les activités de différentiation et de prolifération des cellules à ces niveaux.
L'irradiation a eu comme effet tardif l'apparition de cellules à noyau géant et de mitoses présentant probablement un nombre polyploïde de chromosomes.
Les résultats obtenus sont analysées et discutées.
Summary
The radiosensitivity of cells in the different zones of lens epithelium was sistematically studied in rats whose right eye was irradiated with 1000 r X rays.
The post-equatorial and the equatorial zones of the lens epithelium were found highly damaged in connection with the differentiating and proliferative activity of the cells in these areas.
Cells with giant nuclei and giant mitoses are frequent in the lens epithelium as a late effect of irradiation.
Results are discussed.
Zusammenfassung
Die Radiosensibilität der Zellen in den verschiedenen Zonen des Linsenepithels wurde an Ratten untersucht, bei denen das rechte Auge mit 1000 r bestrahlt wurde.
Die post-equatoriale und die equatoriale Zone des Epithels erwiesen sich als besonders empfindlich, in Zusammenhang mit der Differentiations- und Proliferationstätigkeit der Zellen in diesen Gebieten.
Riesenkernzellen und Riesenmitosen waren häufig im Linsenepithel als Spätwirkung der Bestrahlung zu finden.
Die erhobenen Befunde werden analysiert und besprochen.
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Questo lavoro è stato iniziato mentre il Dr. Scullica si trovava presse il "National Institute of Neurological Diseases and Blindness - National Institutes of Health, Bethesda, Md., U.S.A.
Clinica Oculistica dell'Università (Direttore Prof. G. B. Bietti)
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Scullica, L. Alterazioni istopatologiche dell'epitelio lenticolare dopo Roentgen - Irradiazione. Doc Ophthalmol 16, 231–239 (1962). https://doi.org/10.1007/BF00146730
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DOI: https://doi.org/10.1007/BF00146730