With a view to elaborating a bioactive bone substitute, the association of an artificial extracellular matrix, basically constituted of elastin-solubilized peptides (ESP) and type I+III collagens, with different types of calcium phosphates, was investigated. This paper describes the selective adsorption of ESP on some calcium phosphate samples, and the further association of the adsorbed peptides with type I+III collagens. A preliminary study of the material cytotoxicity was carried out, investigating the behaviour of human osteoblast cells in contact with the yielded composite material.
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References
C. Rey, Biomaterials 11 (1991) 13.
G. Daculsi and N. Passuti, in “Bioceramics II”, edited by H. Onishi and Hemcke (Ishigakuro, Tokyo, 1991) pp. 345–354.
A. Sugaya, M. Minabe, T. Tamura, T. Hori and Y. Watanave, J. Periodont. Res. 24 (1989) 284.
D. A. Glass, J. T. Mellonig and H. J. Towle, J. Periodont. Res. 60 (1989) 121
M. Rabaud, F. Lefebvre and D. Ducassou, Biomaterials 12 (1991) 313.
F. Lefebvre, S. Gorecki, R. Bareille, J. Amedee, L. Bordenave and M. Rabaud Biomaterials, 13 (1992) 28.
L. Bordenave, F. Lefebrve, R. Bareille, F. Rouais, C. Baquey and M. Rabaud Biomaterials, 13 (1992) 439.
M. P. Jacob and W. Hornebeck, in “Frontiers of Matrix Biology”, vol. 10, edited by L. Robert (Créteil, Karget, Basel, 1989), p. 92.
M. F. Harmand, L. Bordenave, R. Duphil and D. Ducassou, Calcif. Tissue Int. 36 (1984) 29.
Association Française de normmalisation (AFNOR), Comission “Biocompatibilité des implants chirurgicaux”. “Matériel Médico-chirurgical. Biocompatibilité des Implants Chirurgicaux. Méthodes d'Extraction”, S93F, Dec. 12, Pr. S. 90.701 (April 1977).
T. Mosmann, J. Immunol. Methods 65 (1983) 55.
G. A. Ackerman, Lab. Invest. 11 (1962) 563.
L. S. Kaplow, Ann. NY Acad. Sci. 155 (1968) 911.
G. Bernardi and T. Kawasaki, Biochim. Biophys. Acta 160 (1968) 301.
C. J. Kirkpatrick and C. Mittermayer, J. Mater. Sci. Mater. Med. 1 (1990) 9.
T. Rae, in “Technics of Biocompatibility Testing”, edited by D. F. Williams, (CRC Press, Boca Raton, Florida, 1986) p. 81.
M. Gregoire, I. Orly and J. Menanteau, J. Biomed. Mater. Res. 24 (1990) 165.
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Rovira, A., Bareille, R., Lopez, I. et al. Preliminary report on a new composite material made of calcium phosphate, elastin peptides and collagens. J Mater Sci: Mater Med 4, 372–380 (1993). https://doi.org/10.1007/BF00122195
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DOI: https://doi.org/10.1007/BF00122195