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Abbreviations
- BLA:
-
beta-lactam antibiotic
References
CONAWAY, R.C. and LEHMAN, I.R. (1982). A DNA primase activity associated with DNA polymerase-α from Drosophila melanogaster embryo. Proc. Nat. Acad. Sci. USA 9:2523–2527.
COTTAGNOUD, P. and NEFTEL, K.A. (1986). Beta-lactams act on DNA synthesis in K-562 cells. Cell Biol. Toxicol. 2:523–529.
HüBSCHER, U., KüNZL, C.C. and SPADARI, S. (1979). Functional roles of DNA polymerase-β and γ. Proc. Nat. Acad. Sci. USA 76:2316–2320.
HüBSCHER, U. and KORNBERG, A. (1979). The δ subunit of Escherichia coli DNA polymerase III holoenzyme is the dnaX gene product. Proc. Nat. Acad. Sci. USA 76:6284–6288.
HüBSCHER, U., GERSCHWILER, P. and McMASTER, G.K. (1982). A mammalian DNA polymerase-α holoenzyme functioning on defined in vivo-like templates. EMBO Journal 1:1513–1559.
HüBSCHER, U. (1983). The mammalian primase is part of a high molecular weight DNA polymerase-α polypeptide. EMBO Journal 2:133–136.
HüBSCHER, U. (1984). DNA polymerase holoenzymes. Trends Biochem. Sci. 9:390–393.
HüGIN, A.W., CERNY, A., ZINKERNAGEL, R.M. and NEFTEL, K.A. (1986). Suppressive effects of B-lactam-antibiotics on in vitro generation of cytotoxic T-cells. Int. J. Immunopharmacol., in press.
NEFTEL, K.A., HAUSER, S.P. and MüLLER, M.R. (1985). Inhibition of granulopoiesis in vivo and in vitro by betalactam antibiotics. J. Inf. Dis. 52:90–98.
NEFTEL, K.A., MüLLER, M.R., WWIDER, U. and HüGIN, A.W. (1986). Beta-lactam antibiotics inhibit human in vitro granulopoiesis and proliferation of some other cell types. Cell Biol. Toxicol. 2:513–521.
OTTIGER, H.P. and HüBSCHER, U. (1984). Mammalian DNA polymerase-a holoenzymes with possible functions at the leading and lagging strand of the replication fork. Proc. Nat. Acad. Sci. USA 81:3993–3997.
SADOWSKI, P. and HURWITZ, J. (1969). Enzymatic breakage of deoxyribonucleic acid. J. Biol. Chem. 244:6192–6198.
SPADARI, S., SALA, F. and PEDRALI-NOY, G. (1982). Aphidicolin, a specific inhibitor of nuclear DNA replication in eukaryotes. Trends Biochem. Sci. 7:29–32.
WASER, J., HüBSCHER, U., KüNZLE, C.C. and SPADARI, S. (1979). DNA polymeraseβ from brain neurons is a repair enzyme. Eur. J. Biochem. 97:361–368.
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Hübscher, U., Huynh, U.D., Hässig, M. et al. Effects of beta-lactams on DNA replication. Cell Biol Toxicol 2, 541–548 (1986). https://doi.org/10.1007/BF00117856
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DOI: https://doi.org/10.1007/BF00117856