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Cell Wall-Anchored Surface Proteins of Staphylococcus aureus

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Staphylococcus aureus

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Abstract

Staphylococcus aureus expresses a plethora of proteins that are covalently anchored to cell wall peptidoglycan. They are classified on the basis of structural and functional properties. Several proteins are multifunctional. They promote adhesion to host cells and tissue, invasion of non-phagocytic host cells, evasion of innate and adaptive immune responses, biofilm formation and iron acquisition. Their roles in host colonization and pathogenesis of infectious diseases have been demonstrated in animal models.

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Abbreviations

Aap:

Accumulation associated protein

AD:

Atopic dermatitis

AdsA:

Adenosine synthase

AFM:

Atomic force microscopy

CA-MRSA:

Community associated MRSA

CAUTI:

Catheter associated urinary tract infection

Clf:

Clumping factor

Cna:

Collagen binding adhesin

CWA:

Cell wall-anchored

dAMP:

2′-Deoxyadenosine 3′ monophosphate

DEv-IgG:

DE variant-immunoglobulin G fold

DLL:

Dock lock latch

ECM:

Extracellular matrix

Fg:

Fibrinogen

FIVAR:

Found in various architectures

Fn:

Fibronectin

FnBP:

Fibronectin binding protein

FnBR:

Fibronectin binding repeats

Gtf:

Glycosyltransferase

Isd:

Iron-regulated surface determinant

LPXTG:

Leucine, proline, any residue, threonine, glycine

MRSA:

Methicillin resistant Staphylococcus aureus

MSCRAMM:

Microbial surface component recognizing adhesive matrix molecules

NEAT:

Near transporter

NET:

Neutrophil extracellular trap

Neu5AC:

N-acetyl neuraminic acid

Plg:

Plasminogen

RGD:

Arginine glycine aspartate

Sbi:

Second immunoglobulin binding protein

SCCmec:

Staphylococcal chromosome cassette, methicillin resistance

SCV:

Small colony variant

Sdr:

Serine rich repeat protein

Spa:

Staphylococcal protein A

SraP:

Serine rich adhesin for platelets

SSR1:

Short serine-rich repeat region

WTA:

Wall teichoic acid

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  1. Microbiology Department, Trinity College Dublin, Dublin, Ireland

    Timothy J. Foster

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  1. Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan

    Akio Nakane

  2. Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan

    Krisana Asano

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Foster, T.J. (2024). Cell Wall-Anchored Surface Proteins of Staphylococcus aureus. In: Nakane, A., Asano, K. (eds) Staphylococcus aureus. Springer, Singapore. https://doi.org/10.1007/978-981-99-9428-1_2

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