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Nanotechnological Drug Delivery Strategies in Epilepsy

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Drug Delivery Strategies in Neurological Disorders: Challenges and Opportunities

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Abstract

Epilepsy is a chronic disease of the central nervous system characterized by an electrical imbalance in neurons. It is the second most prevalent neurological disease, with 50 million people affected worldwide. Although there are a wide range of drugs approved for epilepsy, 30% of the patients do not respond to these treatments. In this context, nanomedicine constitutes a promising alternative to enhance the central nervous system bioavailability of antiepileptic drugs. The encapsulation of different active compounds in nanocarriers gives rise to enhanced effectiveness mainly due to their targeting and penetration into the deepest brain regions as well as the protection of the encapsulated drug. Thus, in this chapter we explore the recent advances in the development of different controlled drug delivery systems for the management of epilepsy disorders.

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Abbreviations

AEDs:

Antiepileptic drugs

AMT:

Adsorptive-mediated transcytosis

BBB:

Blood–brain barrier

CNS:

Central nervous system

CPP:

Cell penetrated peptide

EGCG:

Epigallocatechin-3-gallate

ILAE:

International League Against Epilepsy

NLC:

Nanostructured lipid carriers

NPs:

Nanoparticles

PEG:

Polyethylene glycol

PLGA:

Poly lactic-co-glycolic acid

SLNs:

Solid lipid nanoparticles

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Acknowledgments

A. Cano acknowledges the support of the Instituto de Salud Carlos III (ISCIII) under the grant Sara Borrell (CD22/00125) and Ministerio de Ciencia e Innovación, Proyectos de Generación de Conocimiento grant PID2021-122473OA-I00 and grant PID2021-122187NB-C32. E.S.L. acknowledges the support of the Requalification of the Spanish University System Program.

Author information

Author notes

  1. Elena Sánchez-López and Amanda Cano contributed equally to this work.

Authors and Affiliations

  1. Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain

    Gerard Esteruelas, Lorena Bonilla, Marta Espina, Mª. Luisa García, Elena Sánchez-López & Amanda Cano

  2. Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain

    Gerard Esteruelas, Lorena Bonilla, Marta Espina, Mª. Luisa García, Elena Sánchez-López & Amanda Cano

  3. Unit of Synthesis and Biomedical Applications of Peptides, IQAC-CSIC, Barcelona, Spain

    Gerard Esteruelas, Isabel Haro, María José Gómara & Elena Sánchez-López

  4. Centre for Biomedical Research in Neurodegenerative Diseases Network (CIBERNED), Carlos III Health Institute, Madrid, Spain

    Miren Ettcheto, Antonio Camins, Mª. Luisa García, Elena Sánchez-López & Amanda Cano

  5. Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain

    Miren Ettcheto

  6. Institute of Neurosciences, University of Barcelona, Barcelona, Spain

    Miren Ettcheto

  7. Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Porto, Portugal

    Eliana B. Souto & Antonio Camins

  8. REQUIMTE/UCIBIO, Faculty of Pharmacy, University of Porto, Porto, Portugal

    Eliana B. Souto & Antonio Camins

  9. Ace Alzheimer Center Barcelona – Universitat Internacional de Catalunya, Barcelona, Spain

    Amanda Cano

Authors
  1. Gerard Esteruelas
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  2. Lorena Bonilla
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  3. Miren Ettcheto
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  4. Isabel Haro
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  5. María José Gómara
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  6. Eliana B. Souto
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  7. Marta Espina
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  8. Antonio Camins
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  9. Mª. Luisa García
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  10. Elena Sánchez-López
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  11. Amanda Cano
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Corresponding authors

Correspondence to Elena Sánchez-López or Amanda Cano .

Editor information

Editors and Affiliations

  1. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India

    Awanish Mishra

  2. School of Nano Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India

    Hitesh Kulhari

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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Esteruelas, G. et al. (2023). Nanotechnological Drug Delivery Strategies in Epilepsy. In: Mishra, A., Kulhari, H. (eds) Drug Delivery Strategies in Neurological Disorders: Challenges and Opportunities. Springer, Singapore. https://doi.org/10.1007/978-981-99-6807-7_14

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  • DOI: https://doi.org/10.1007/978-981-99-6807-7_14

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  • Online ISBN: 978-981-99-6807-7

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