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A Magnetically Actuated Diatom-Biohybrid Microrobot as a Drug Delivery Capsule

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Intelligent Robotics and Applications (ICIRA 2023)

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 14272))

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Abstract

Targeted drug delivery is a strategy to efficiently deliver drugs to a specific target area and has broad application prospects in the treatment of cancer, inflammatory diseases, and neurological diseases. Currently, biohybrid microrobots have been developed as drug-carrying systems and have great potential in the field of drug delivery. However, the efficient carrying and delivery of drugs is still an urgent problem to be solved in the design of drug delivery systems. Here, we fabricated a Thalassiosira weissflogii-based biohybrid microrobot as a drug delivery capsule for targeted therapy. Diatom frustules with complete cavities were obtained through a simple and economical preparation method. The drugs were encapsulated into the cavity of the diatom frustules by means of vacuum loading, so that they had good drug-loading properties. The magnetic engine is loaded onto the surface of frustules by electrostatic adsorption, so that they can achieve flexible and controllable movement under the action of an external rotating magnetic field, which is expected to achieve targeted drug delivery. The prepared diatom microrobots have great application potential for drug delivery platforms.

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Acknowledgments

This work was supported by the CAS Project for Young Scientists in Basic Research (Grant No. YSBR-036), and National Natural Science Foundation of China (Grant Nos. 62273331, 61925307, 62127811, 61821005), and CAS/SAFEA International Partnership Program for Creative Research Teams.

Author information

Authors and Affiliations

  1. State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, 110016, China

    Mengyue Li, Niandong Jiao, Xiaodong Wang & Lianqing Liu

  2. Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang, 110016, China

    Mengyue Li, Niandong Jiao, Xiaodong Wang & Lianqing Liu

  3. University of Chinese Academy of Sciences, Beijing, 100049, China

    Mengyue Li, Niandong Jiao & Xiaodong Wang

Authors
  1. Mengyue Li
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  2. Niandong Jiao
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  3. Xiaodong Wang
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  4. Lianqing Liu
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Corresponding author

Correspondence to Niandong Jiao .

Editor information

Editors and Affiliations

  1. Zhejiang University, Hangzhou, China

    Huayong Yang

  2. Harbin Institute of Technology, Shenzhen, China

    Honghai Liu

  3. Zhejiang University, Hangzhou, China

    Jun Zou

  4. Huazhong University of Science and Technology, Wuhan, China

    Zhouping Yin

  5. Shenyang Institute of Automation, Shenyang, Liaoning, China

    Lianqing Liu

  6. Zhejiang University, Hangzhou, China

    Geng Yang

  7. Zhejiang University, Hangzhou, China

    Xiaoping Ouyang

  8. Harbin Institute of Technology, Shenzhen, China

    Zhiyong Wang

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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Li, M., Jiao, N., Wang, X., Liu, L. (2023). A Magnetically Actuated Diatom-Biohybrid Microrobot as a Drug Delivery Capsule. In: Yang, H., et al. Intelligent Robotics and Applications. ICIRA 2023. Lecture Notes in Computer Science(), vol 14272. Springer, Singapore. https://doi.org/10.1007/978-981-99-6480-2_39

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  • DOI: https://doi.org/10.1007/978-981-99-6480-2_39

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-6479-6

  • Online ISBN: 978-981-99-6480-2

  • eBook Packages: Computer ScienceComputer Science (R0)

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