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Fungal Endophytes: An Accessible Natural Repository for Discovery of Bioactive Compounds

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Fungi Bioactive Metabolites

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Abstract

Microorganisms are proficient synthesizers of natural product molecules that are often bioactive and a source of various antibiotics and other pharmaceutical agents. The demand for new bioactive molecules is ever-increasing due to the emergence of new diseases, novel pathogens, and drug-resistant microbes. It is imperative to extend our search for molecules with novel bioactivities from unique and unexplored niches. Since the discovery of microbial Taxol (1), from a fungus inhabiting the tissues of Taxus brevifolia, endophytes, the microbes living within the plant tissues in mutualistic associations, have become an important source for the discovery of bioactive molecules. Since the endophytic associations are plant-specific, each plant forms a unique niche for the accumulation of a specific set of microbial species. The endophytes also pass through various stages of evolution within the plant system to evolve their natural product arsenal. Consequently, numerous plants are being analysed for the isolation and characterization of their endophytes for bioactive molecules and enzymes. Here, we report the progress of research and the current status of endophyte biology and biochemistry for the production of bioactive natural products.

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Authors and Affiliations

  1. Fermentation and Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Srinagar, Jammu and Kashmir, India

    Malik Muzafar Manzoor & Syed Riyaz-Ul-Hassan

  2. Department of Botany, Government Degree College Anantnag, Anantnag, Jammu and Kashmir, India

    Zahoor Ahmed Wani

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  1. Malik Muzafar Manzoor
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  2. Zahoor Ahmed Wani
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  3. Syed Riyaz-Ul-Hassan
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Correspondence to Syed Riyaz-Ul-Hassan .

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  1. Research and Development, Greenvention Biotech Pvt. Ltd., Pune, Maharashtra, India

    Sunil Kumar Deshmukh

  2. Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

    Jacqueline Aparecida Takahashi

  3. Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, Punjab, India

    Sanjai Saxena

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Manzoor, M.M., Wani, Z.A., Riyaz-Ul-Hassan, S. (2024). Fungal Endophytes: An Accessible Natural Repository for Discovery of Bioactive Compounds. In: Deshmukh, S.K., Takahashi, J.A., Saxena, S. (eds) Fungi Bioactive Metabolites. Springer, Singapore. https://doi.org/10.1007/978-981-99-5696-8_3

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