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Epigenetic Regulators of Inflammatory Gene Expression

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Targeting Epigenetics in Inflammatory Lung Diseases

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Abstract

Epigenetics is defined as changes in the expression of genes whose core is confined within a non-expressed portion of DNA. All the mechanisms of epigenetics including DNA methylation, acetylation of histones and micro-RNAs and all these factors are under the direct control of diet, age, maternal mental health and environmental factors. There is an increasing suggestion of epigenetics in the expansion of several lung diseases. Epigenetics also exerts its influence over inflammation which is a common feature of many lungs inflammatory diseases including COPD, asthma and IPF. All the immune cells which play a vital part in the growth of inflammation also fall under the control of epigenetic changes. Epigenetics influences both adaptive and innate branches of protection to bring inflammation at a heightened rate in inflammatory diseases by controlling their activity and differentiation. Immune cells are generally associated with protective responses to harm in lung inflammatory diseases. Hence, therapeutics targeting epigenetics have emerged as attractive candidates that in addition to controlling epigenetic mechanisms control gene activity, thus providing a suitable alternative in place of already available drugs.

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Authors and Affiliations

  1. Laboratory of Translational Medicine and Nanotherapeutics, Department of Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab, Bathinda, India

    Satinder Kaur, Jayapriya Mishra, Abhishek Sehrawat & Jasvinder Singh Bhatti

  2. Department of Medical Lab Technology, University Institute of Applied Health Sciences, Chandigarh University, Mohali, India

    Gurjit Kaur Bhatti

  3. Department of Pharmacology, School of Health Sciences, Central University of Punjab, Bathinda, India

    Umashanker Navik

  4. Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA

    P. Hemachandra Reddy

  5. Department of Pharmacology and Neuroscience and Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA

    P. Hemachandra Reddy

  6. Department of Public Health, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, Lubbock, TX, USA

    P. Hemachandra Reddy

  7. Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX, USA

    P. Hemachandra Reddy

  8. Department of Speech, Language, and Hearing Sciences, Texas Tech University Health Sciences Center, Lubbock, TX, USA

    P. Hemachandra Reddy

  9. Nutritional Sciences Department, College of Human Sciences, Texas Tech University, Lubbock, TX, USA

    P. Hemachandra Reddy

Authors
  1. Satinder Kaur
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  2. Jayapriya Mishra
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  3. Abhishek Sehrawat
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  4. Gurjit Kaur Bhatti
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  5. Umashanker Navik
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  6. P. Hemachandra Reddy
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  7. Jasvinder Singh Bhatti
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Corresponding author

Correspondence to Jasvinder Singh Bhatti .

Editor information

Editors and Affiliations

  1. School of Pharmacy, Suresh Gyan University, Jaipur, Rajasthan, India

    Gaurav Gupta

  2. Department of Science, University of Technology Sydney, Ultimo, NSW, Australia

    Brian G. Oliver

  3. Discipline of Pharmacy, University of Technology Sydney, Schofields, NSW, Australia

    Kamal Dua

  4. Division of Pulmonary and Critical Care Medicine, Stanford Medicine, Stanford, CA, USA

    Md Khadem Ali

  5. School of Pharmacy, Gyan Vihar University, Jaipur, Rajasthan, India

    Piyush Dave

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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Kaur, S. et al. (2023). Epigenetic Regulators of Inflammatory Gene Expression. In: Gupta, G., Oliver, B.G., Dua, K., Ali, M.K., Dave, P. (eds) Targeting Epigenetics in Inflammatory Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-99-4780-5_4

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