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Epigenetics of Influenza: The Host-Virus Interaction.

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Targeting Epigenetics in Inflammatory Lung Diseases

Abstract

With advancements in science and technology, an equivalent growth in diseases has also been observed. A disease that has remained prevalent for decades, showing an almost incomparable persistence and adaptability is influenza. With increasing research on DNA, we now know that external influences, like influenza, can successfully alter gene expression with lasting effects through epigenetics. In this chapter, the possible role that both influenza and its host play on an epigenetic level to alter each other’s gene expression will be explored along with the possible effects these epigenetic changes have on virulence, the immune system, and other cellular mechanisms.

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References

  1. Riddihough G, Zahn LM. What is epigenetics? American Association for the Advancement of Science; 2010. p. 611.

    Google Scholar 

  2. Marcos-Villar L, Díaz-Colunga J, Sandoval J, Zamarreño N, Landeras-Bueno S, Esteller M, et al. Epigenetic control of influenza virus: role of H3K79 methylation in interferon-induced antiviral response. Sci Rep. 2018;8(1):1–13.

    Article  CAS  Google Scholar 

  3. Mosnier A, Caini S, Daviaud I, Nauleau E, Bui TT, Debost E, et al. Clinical characteristics are similar across type a and B influenza virus infections. PLoS One. 2015;10(9):e0136186.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Hirsch A. Handbook of geographical and historical pathology. New Sydenham Society; 1883.

    Google Scholar 

  5. Taubenberger JK, Morens DM. The pathology of influenza virus infections. Annu Rev Pathol. 2008;3:499.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Bannister S, Messina NL, Novakovic B, Curtis N. The emerging role of epigenetics in the immune response to vaccination and infection: a systematic review. Epigenetics. 2020;15(6-7):555–93.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Dou D, Revol R, Östbye H, Wang H, Daniels R. Influenza a virus cell entry, replication, Virion Assembly and movement. Front Immunol. 2018;9:1581.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Keshavarz M, Sabbaghi A, Koushki K, Miri SM, Sarshari B, Vahdat K, et al. Epigenetic reprogramming mechanisms of immunity during influenza A virus infection. Microbes Infect. 2021;23(8):104831.

    Article  CAS  PubMed  Google Scholar 

  9. Li S, Kong L, Yu X, Zheng Y. Host–virus interactions: from the perspectives of epigenetics. Rev Med Virol. 2014;24(4):223–41.

    Article  CAS  PubMed  Google Scholar 

  10. Kouzarides T. Chromatin modifications and their function. Cell. 2007;128(4):693–705.

    Article  CAS  PubMed  Google Scholar 

  11. Marcos-Villar L, Díaz-Colunga J, Sandoval J, Zamarreño N, Landeras-Bueno S, Esteller M, et al. Epigenetic control of influenza virus: role of H3K79 methylation in interferon-induced antiviral response. Sci Rep. 2018;8(1):1230.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Hughes LAE, van den Brandt PA, de Bruïne AP, Wouters KAD, Hulsmans S, Spiertz A, et al. Early life exposure to famine and colorectal cancer risk: a role for epigenetic mechanisms. PLoS One. 2009;4(11):e7951.

    Article  PubMed  PubMed Central  Google Scholar 

  13. de Vogel S, Bongaerts BW, Wouters KA, Kester AD, Schouten LJ, de Goeij AF, et al. Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer. Carcinogenesis. 2008;29(9):1765–73.

    Article  PubMed  Google Scholar 

  14. Ling C, Rönn T. Epigenetic adaptation to regular exercise in humans. Drug Discov Today. 2014;19(7):1015–8.

    Article  CAS  PubMed  Google Scholar 

  15. He Y, Zhao Y, Zhang S, Chen W, Lin S, Yang Q, et al. Not polymorphism but methylation of class II transactivator gene promoter IV associated with persistent HBV infection. J Clin Virol. 2006;37(4):282–6.

    Article  CAS  PubMed  Google Scholar 

  16. Zheng L, Leung ETY, Wong HK, Lui G, Lee N, To K-F, et al. Unraveling methylation changes of host macrophages in Mycobacterium tuberculosis infection. Tuberculosis. 2016;98:139–48.

    Article  CAS  PubMed  Google Scholar 

  17. Chertow DS, Memoli MJ. Bacterial coinfection in influenza: a grand rounds review. JAMA. 2013;309(3):275–82.

    Article  CAS  PubMed  Google Scholar 

  18. Morens DM, Taubenberger JK, Fauci AS. Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J Infect Dis. 2008;198(7):962–70.

    Article  PubMed  Google Scholar 

  19. Didierlaurent A, Goulding J, Patel S, Snelgrove R, Low L, Bebien M, et al. Sustained desensitization to bacterial Toll-like receptor ligands after resolutionof respiratory influenza infection. J Exp Med. 2008;205(2):323–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Mukherjee S, Vipat VC, Chakrabarti AK. Infection with influenza a viruses causes changes in promoter DNA methylation of inflammatory genes. Influenza Other Respir Viruses. 2013;7(6):979–86.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Steger DJ, Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhuo D, et al. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol. 2008;28(8):2825–39.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Menachery VD, Schäfer A, Burnum-Johnson KE, Mitchell HD, Eisfeld AJ, Walters KB, et al. MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape. Proc Natl Acad Sci U S A. 2018;115(5):E1012–E21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Shirey KA, Perkins DJ, Lai W, Zhang W, Fernando LR, Gusovsky F, et al. Influenza "trains" the host for enhanced susceptibility to secondary bacterial infection. MBio. 2019;10:3.

    Article  Google Scholar 

  24. Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen J-L. Host immune response to influenza a virus infection. Front Immunol. 2018;9:320.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Ashraf U, Benoit-Pilven C, Lacroix V, Navratil V, Naffakh N. Advances in analyzing virus-induced alterations of host cell splicing. Trends Microbiol. 2019;27(3):268–81.

    Article  CAS  PubMed  Google Scholar 

  26. Zhang L, Wang J, Muñoz-Moreno R, Kim M, Sakthivel R, Mo W, et al. Influenza virus NS1 protein-RNA interactome reveals intron targeting. J Virol. 2018;92(24):e01634-18.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Heinz S, Texari L, Hayes MGB, Urbanowski M, Chang MW, Givarkes N, et al. Transcription elongation can affect genome 3D structure. Cell. 2018;174(6):1522–36.e22

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Zhao N, Sebastiano V, Moshkina N, Mena N, Hultquist J, Jimenez-Morales D, et al. Influenza virus infection causes global RNAPII termination defects. Nat Struct Mol Biol. 2018;25(9):885–93.

    Article  CAS  PubMed  Google Scholar 

  29. Bauer DLV, Tellier M, Martínez-Alonso M, Nojima T, Proudfoot NJ, Murphy S, et al. Influenza virus mounts a two-pronged attack on host RNA polymerase II transcription. Cell Rep. 2018;23(7):2119–29.e3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. More S, Zhu Z, Lin K, Huang C, Pushparaj S, Liang Y, et al. Long non-coding RNA PSMB8-AS1 regulates influenza virus replication. RNA Biol. 2019;16(3):340–53.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Ichida Y, Matsushita K, Fujiwara Y, Hoshizaki M, Fujiwara S, Kuba K, et al. Influenza virus infection affects host epigenome structure associated with histone methylation. 日本薬理学会年会要旨集. 2018;WCP2018:PO2-11-24.

    Google Scholar 

  32. Marazzi I, Ho JSY, Kim J, Manicassamy B, Dewell S, Albrecht RA, et al. Suppression of the antiviral response by an influenza histone mimic. Nature. 2012;483(7390):428–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Vasileva D, Badawi A. C-reactive protein as a biomarker of severe H1N1 influenza. Inflamm Res. 2019;68(1):39–46.

    Article  CAS  PubMed  Google Scholar 

  34. Davey RT Jr, Lynfield R, Dwyer DE, Losso MH, Cozzi-Lepri A, Wentworth D, et al. The association between serum biomarkers and disease outcome in influenza A (H1N1) pdm09 virus infection: results of two international observational cohort studies. PLoS One. 2013;8(2):e57121.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Peng F, He J, Loo JFC, Yao J, Shi L, Liu C, et al. Identification of microRNAs in throat swab as the biomarkers for diagnosis of influenza. Int J Med Sci. 2016;13(1):77.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Hernandez-Vargas EA, Wilk E, Canini L, Toapanta FR, Binder SC, Uvarovskii A, et al. Effects of aging on influenza virus infection dynamics. J Virol. 2014;88(8):4123–31.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Hu J, Zhang L, Liu X. Role of post-translational modifications in influenza a virus life cycle and host innate immune response. Front Microbiol. 2020;11:517461.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Hatakeyama D, Shoji M, Yamayoshi S, Yoh R, Ohmi N, Takenaka S, et al. Influenza A virus nucleoprotein is acetylated by histone acetyltransferases PCAF and GCN5. J Biol Chem. 2018;293(19):7126–38.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Nishioka K, Daidoji T, Nakaya T. Demethylation around the transcriptional start site of the IFN-β gene induces IFN-β production and protection against influenza virus infection. Biochem Biophys Res Commun. 2019;520(2):269–76.

    Article  CAS  PubMed  Google Scholar 

  40. Tang B, Zhao R, Sun Y, Zhu Y, Zhong J, Zhao G, et al. Interleukin-6 expression was regulated by epigenetic mechanisms in response to influenza virus infection or dsRNA treatment. Mol Immunol. 2011;48(8):1001–8.

    Article  CAS  PubMed  Google Scholar 

  41. Fang J, Hao Q, Liu L, Li Y, Wu J, Huo X, et al. Epigenetic changes mediated by MicroRNA miR29 activate cyclooxygenase 2 and Lambda-1 interferon production during viral. Infection. 2012;86(2):1010–20.

    CAS  Google Scholar 

  42. LeMessurier KS, Rooney R, Ghoneim HE, Liu B, Li K, Smallwood HS, et al. Influenza A virus directly modulates mouse eosinophil responses. J Leukoc Biol. 2020;108(1):151–68.

    Article  CAS  PubMed  Google Scholar 

  43. Li W, Sun W, Liu L, Yang F, Li Y, Chen Y, et al. IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza a virus infection. J Immunol. 2010;185(9):5056–65.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. KAM School of Life Sciences, Forman Christian College (A Chartered University), Lahore, Pakistan

    Muhammad Mustafa

  2. Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

    Muhammad Shahid Nadeem, Abeer Asif & Imran Kazmi

Authors
  1. Muhammad Mustafa
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  2. Muhammad Shahid Nadeem
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  3. Abeer Asif
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  4. Imran Kazmi
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Editor information

Editors and Affiliations

  1. School of Pharmacy, Suresh Gyan University, Jaipur, Rajasthan, India

    Gaurav Gupta

  2. Department of Science, University of Technology Sydney, Ultimo, NSW, Australia

    Brian G. Oliver

  3. Discipline of Pharmacy, University of Technology Sydney, Schofields, NSW, Australia

    Kamal Dua

  4. Division of Pulmonary and Critical Care Medicine, Stanford Medicine, Stanford, CA, USA

    Md Khadem Ali

  5. School of Pharmacy, Gyan Vihar University, Jaipur, Rajasthan, India

    Piyush Dave

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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Mustafa, M., Nadeem, M.S., Asif, A., Kazmi, I. (2023). Epigenetics of Influenza: The Host-Virus Interaction.. In: Gupta, G., Oliver, B.G., Dua, K., Ali, M.K., Dave, P. (eds) Targeting Epigenetics in Inflammatory Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-99-4780-5_10

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