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Computational Validation and Nanofabrication of Withania Somifera Extract for CNS Targeting Against Alzheimer’s Disease

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Recent Trends in Nanotechnology for Sustainable Living and Environment (ICON-NSLE 2022)

Part of the book series: Lecture Notes in Mechanical Engineering ((LNME))

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Abstract

The prevalence and distribution of Central nervous system (CNS) disorders are increasing globally until 2021. It was estimated that 55 million people worldwide were already affected by dementia or Alzheimer's disease (AD). As a result, effective bioactive chemicals are in high demand. Withania somnifera is an Indian herb that has been used to treat a variety of neurological disorders. In our study, we have computationally evaluated the efficacy of Withania somnifera for their neuroprotective targets against AD. Thereafter, they have been formulated for the oil-in-water nano-emulsion system and optimized to attain the nanometric size range. Subsequently, Withania somnifera nanoemulsions were developed by selecting Linseed oil, Tween 20, and Ethanol as oil, surfactant, and co-surfactant respectively with an aqueous titration method. The characterization results exhibited the nanometric size range of the optimized nano-formulations.

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Acknowledgements

The research group is thankful to Jaypee Institute of Information Technology, Noida for providing the facility to carry out fabrication of nano-formulation work.

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Authors and Affiliations

  1. Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Noida Sector-62, 201301, Uttar Pradesh, India

    Divya Jindal, Pranav Pancham, Shalini Mani,  Rachana, Shazia Haider & Manisha Singh

Authors
  1. Divya Jindal
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  2. Pranav Pancham
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  3. Shalini Mani
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  4. Rachana
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  5. Shazia Haider
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  6. Manisha Singh
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Corresponding author

Correspondence to Manisha Singh .

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Editors and Affiliations

  1. Department of Chemical Engineering, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India

    Rabibrata Mukherjee

  2. Institute of Inorganic and Structural Chemistry, Heinrich Heine University, Düsseldorf, Germany

    Christoph Janiak

  3. Linköping University, Linköping, Sweden

    Ziyauddin Khan

  4. Department of Chemical Engineering, Birla Institute of Technology and Science, Pilani, Rajasthan, India

    Somak Chatterjee

  5. Department of Chemical Engineering, Birla Institute of Technology and Science, Pilani, Rajasthan, India

    Banasri Roy

  6. Department of Chemical Engineering, Birla Institute of Technology and Science, Pilani, Rajasthan, India

    Sarbani Ghosh

  7. Department of Chemical Engineering, Birla Institute of Technology and Science, Pilani, Rajasthan, India

    Krishna Etika

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Jindal, D., Pancham, P., Mani, S., Rachana, Haider, S., Singh, M. (2023). Computational Validation and Nanofabrication of Withania Somifera Extract for CNS Targeting Against Alzheimer’s Disease. In: Mukherjee, R., et al. Recent Trends in Nanotechnology for Sustainable Living and Environment. ICON-NSLE 2022. Lecture Notes in Mechanical Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-99-3386-0_17

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  • DOI: https://doi.org/10.1007/978-981-99-3386-0_17

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-3385-3

  • Online ISBN: 978-981-99-3386-0

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