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Stem Cells Therapy for Cartilage Regeneration in Clinic: Challenges and Opportunities

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Cartilage: From Biology to Biofabrication

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Abstract

For both academics and clinicians, the repair and regeneration of articular cartilage have offered a challenging array of issues. Injuries to articular cartilage have a poor chance of healing since it is an avascular tissue. Small defects may eventually heal on their own without treatment, but the repair tissue is inferior to the body’s own hyaline cartilage because it is made of fibrocartilage. Due to its regenerative capabilities, the idea of stem cell therapy has sparked intense research into its potential application for treating cartilage lesions, including OA. The purpose of this chapter is to present a perspective on stem cell-based therapy for cartilage repair and to highlight recent developments in advanced cell therapy, in particular, the use of embryonic stem cells, mesenchymal stem cells, and induce pluripotent stem cells for treating diseases associated with cartilage defects, particularly OA.

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Authors and Affiliations

  1. Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Mina Shahnazari, Reza Naeimi, Marzieh Savari, Niloofar Shokrollah & Mohsen Sheykhhasan

  2. Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA

    Sara Malih

  3. Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

    Sara Malih

  4. Department of Operating Room, School of Nursing and Midwifery, ShahidBeheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

    Parisa Samadi

  5. Department of Mesenchymal Stem Cells, The Academic Center for Education, Culture and Research, Qom, Iran

    Mohsen Sheykhhasan

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  1. Cell Science Research Center, Royan Institute, Tehran, Iran

    Mohamadreza Baghaban Eslaminejad

  2. Cell Science Research Center, Royan Institute, Tehran, Iran

    Samaneh Hosseini

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Shahnazari, M. et al. (2023). Stem Cells Therapy for Cartilage Regeneration in Clinic: Challenges and Opportunities. In: Baghaban Eslaminejad, M., Hosseini, S. (eds) Cartilage: From Biology to Biofabrication. Springer, Singapore. https://doi.org/10.1007/978-981-99-2452-3_17

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