Skip to main content
SpringerLink
Log in

Nanomedicine for Orthopaedics

  • Chapter
  • First Online:
Nanomedicine

Part of the book series: SpringerBriefs in Applied Sciences and Technology ((BRIEFSNANO))

  • 122 Accesses

Abstract

This chapter discusses the usefulness of different nanocomposites for the promotion of angiogenesis, osteogenesis, and bone regeneration. Typical examples include graphene oxide–collagen nanocomposite, polylactic acid (PLA)—carbon nanotubes, dexamethasone-loaded calcium phosphate—collagen nanocomposites, nanofiber scaffolds (e.g., chitosan/poly-ethylene oxide), porous hydroxyapatite (HA) and reduced graphene oxide (rGO) nanocomposite scaffold, and injectable bone cement reinforced with Au NPs decorated HA/rGO nanocomposites for bone regeneration.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 34.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 44.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Adarkwa E, Roy A, Ohodnicki J, Lee B, Kumta PN, Desai S (2023) 3D printing of drug-eluting bioactive multifunctional coatings for orthopedic applications. Int J Bioprint 9(2)

    Google Scholar 

  • Behzadi S, Luther GA, Harris MB, Farokhzad OC, Mahmoudi M (2017) Nanomedicine for safe healing of bone trauma: opportunities and challenges. Biomaterials 146:168–182

    Article  Google Scholar 

  • Biswas DP, O’Brien-Simpson NM, Reynolds EC, O’Connor AJ, Tran PA (2018) Comparative study of novel in situ decorated porous chitosan-selenium scaffolds and porous chitosan-silver scaffolds towards antimicrobial wound dressing application. J Colloid Interface Sci 515:78–91

    Article  ADS  Google Scholar 

  • Chen Y, Chen S, Kawazoe N, Chen G (2018) Promoted angiogenesis and osteogenesis by dexamethasone-loaded calcium phosphate nanoparticles/collagen composite scaffolds with microgroove networks. Sci Rep 8(1):14143

    Article  ADS  Google Scholar 

  • Chopra V, Thomas J, Kaushik S, Rajput S, Guha R, Mondal B, Naskar S, Mandal D, Chauhan G, Chattopadhyay N (2023) Injectable bone cement reinforced with gold nanodots decorated rGO‐hydroxyapatite nanocomposites, augment bone regeneration. Small 2204637

    Google Scholar 

  • Christenson EM, Anseth KS, van den Beucken JJ, Chan CK, Ercan B, Jansen JA, Laurencin CT, Li WJ, Murugan R, Nair LS (2007) Nanobiomaterial applications in orthopedics. J Orthop Res 25(1):11–22

    Article  Google Scholar 

  • Dohnert MB, Venâncio M, Possato JC, Zeferino RC, Dohnert LH, Zugno AI, De Souza CT, Paula MM, Luciano TF (2012) Gold nanoparticles and diclofenac diethylammonium administered by iontophoresis reduce inflammatory cytokines expression in Achilles tendinitis. Int J Nanomed 7:1651

    Article  Google Scholar 

  • Gao X, Xu Z, Li S, Cheng L, Xu D, Li L, Chen L, Xu Y, Liu Z, Liu Y (2023) Chitosan-vancomycin hydrogel incorporated bone repair scaffold based on staggered orthogonal structure: a viable dually controlled drug delivery system. RSC Adv 13(6):3759–3765

    Article  ADS  Google Scholar 

  • Ghaffari R, Salimi-Kenari H, Fahimipour F, Rabiee SM, Adeli H, Dashtimoghadam E (2020) Fabrication and characterization of dextran/nanocrystalline β-tricalcium phosphate nanocomposite hydrogel scaffolds. Int J Biol Macromol 148:434–448

    Article  Google Scholar 

  • Hormozi B (2023) Plant polysaccharides for orthopedic drug delivery. Plant polysaccharides as pharmaceutical excipients. Elsevier, pp 513–532

    Book  Google Scholar 

  • Keller L, Pijnenburg L, Idoux-Gillet Y, Bornert F, Benameur L, Tabrizian M, Auvray P, Rosset P, Gonzalo-Daganzo RM, Barrena EG (2019) Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration. Nat Commun 10

    Google Scholar 

  • Li J, Li K, Du Y, Tang X, Liu C, Cao S, Zhao B, Huang H, Zhao H, Kong W (2023) Dual-nozzle 3D printed nano-hydroxyapatite scaffold loaded with vancomycin sustained-release microspheres for enhancing bone regeneration. Int J Nanomed 307–322

    Google Scholar 

  • Liu S, Mou S, Zhou C, Guo L, Zhong A, Yang J, Yuan Q, Wang J, Sun J, Wang Z (2018) Off-the-shelf biomimetic graphene oxide-collagen hybrid scaffolds wrapped with osteoinductive extracellular matrix for the repair of cranial defects in rats. ACS Appl Mater Interfaces 10(49):42948–42958

    Article  Google Scholar 

  • Liu F, Liu C, Zheng B, He J, Liu J, Chen C, Lee I-S, Wang X, Liu Y (2020) Synergistic effects on incorporation of β-tricalcium phosphate and graphene oxide nanoparticles to silk fibroin/soy protein isolate scaffolds for bone tissue engineering. Polymers 12(1):69

    Article  Google Scholar 

  • Mazaheri M, Eslahi N, Ordikhani F, Tamjid E, Simchi A (2015) Nanomedicine applications in orthopedic medicine: state of the art. Int J Nanomed 10:6039

    Google Scholar 

  • Mo X, Zhang D, Liu K, Zhao X, Li X, Wang W (2023) Nano-hydroxyapatite composite scaffolds loaded with bioactive factors and drugs for bone tissue engineering. Int J Mol Sci 24(2):1291

    Article  Google Scholar 

  • Park H, Kim JS, Oh EJ, Kim TJ, Kim HM, Shim JH, Yoon WS, Huh JB, Moon SH, Kang SS (2018) Effects of three-dimensionally printed polycaprolactone/β-tricalcium phosphate scaffold on osteogenic differentiation of adipose tissue-and bone marrow-derived stem cells. Arch Craniofac Surg 19(3):181

    Article  Google Scholar 

  • Samie M, Khan AF, Rahman SU, Iqbal H, Yameen MA, Chaudhry AA, Galeb HA, Halcovitch NR, Hardy JG (2023) Drug/bioactive eluting chitosan composite foams for osteochondral tissue engineering. Int J Biol Macromol 229:561–574

    Article  Google Scholar 

  • Serra I, Fradique R, M. C. d. S. Vallejo, T. R. Correia, S. P. Miguel and I. Correia, (2015) Production and characterization of chitosan/gelatin/β-TCP scaffolds for improved bone tissue regeneration. Mater Sci Eng C 55:592–604

    Article  Google Scholar 

  • Seyedsalehi A, Daneshmandi L, Barajaa M, Riordan J, Laurencin CT (2020) Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds. Sci Rep 10(1):22210

    Article  ADS  Google Scholar 

  • Song Y, Hu Q, Liu Q, Liu S, Wang Y, Zhang H (2023) Design and fabrication of drug-loaded alginate/hydroxyapatite/collagen composite scaffolds for repairing infected bone defects. J Mater Sci 1–16

    Google Scholar 

  • Sullivan M, McHale K, Parvizi J, Mehta S (2014) Nanotechnology: current concepts in orthopaedic surgery and future directions. Bone Joint J 96(5):569–573

    Article  Google Scholar 

  • Tran PA, O’Brien-Simpson N, Palmer JA, Bock N, Reynolds EC, Webster TJ, Deva A, Morrison WA, O’Connor AJ (2019) Selenium nanoparticles as anti-infective implant coatings for trauma orthopedics against methicillin-resistant Staphylococcus aureus and epidermidis: in vitro and in vivo assessment. Int J Nanomed 14:4613

    Article  Google Scholar 

  • Wang W, Liu Y, Yang C, Qi X, Li S, Liu C, Li X (2019a) Mesoporous bioactive glass combined with graphene oxide scaffolds for bone repair. Int J Biol Sci 15(10):2156–2169

    Article  Google Scholar 

  • Wang X, Lin M, Kang Y (2019b) Engineering porous β-tricalcium phosphate (β-TCP) scaffolds with multiple channels to promote cell migration, proliferation, and angiogenesis. ACS Appl Mater Interfaces 11(9):9223–9232

    Article  Google Scholar 

  • Wang Q, Li M, Cui T, Wu R, Guo F, Fu M, Zhu Y, Yang C, Chen B, Sun G (2023) A novel zwitterionic hydrogel incorporated with graphene oxide for bone tissue engineering: synthesis, characterization, and promotion of osteogenic differentiation of bone mesenchymal stem cells. Int J Mol Sci 24(3):2691

    Article  Google Scholar 

  • Yin Q, Tang L, Cai K, Tong R, Sternberg R, Yang X, Dobrucki LW, Borst LB, Kamstock D, Song Z (2016) Pamidronate functionalized nanoconjugates for targeted therapy of focal skeletal malignant osteolysis. Proc Natl Acad Sci 113(32):E4601–E4609

    Article  Google Scholar 

  • Zhang J, Eyisoylu H, Qin X-H, Rubert M, Müller R (2021) 3D bioprinting of graphene oxide-incorporated cell-laden bone mimicking scaffolds for promoting scaffold fidelity, osteogenic differentiation and mineralization. Acta Biomater 121:637–652

    Article  Google Scholar 

  • Zhou K, Yu P, Shi X, Ling T, Zeng W, Chen A, Yang W, Zhou Z (2019) Hierarchically porous hydroxyapatite hybrid scaffold incorporated with reduced graphene oxide for rapid bone ingrowth and repair. ACS Nano 13(8):9595–9606

    Article  Google Scholar 

  • Zhou P, Xia D, Ni Z, Ou T, Wang Y, Zhang H, Mao L, Lin K, Xu S, Liu J (2021) Calcium silicate bioactive ceramics induce osteogenesis through oncostatin M. Bioact Mater 6(3):810–822

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Alpha Biomedical Pte. Ltd., Singapore, Singapore

    Tamil Selvan Subramanian

Authors
  1. Tamil Selvan Subramanian
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tamil Selvan Subramanian .

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Subramanian, T.S. (2023). Nanomedicine for Orthopaedics. In: Nanomedicine. SpringerBriefs in Applied Sciences and Technology(). Springer, Singapore. https://doi.org/10.1007/978-981-99-2139-3_4

Download citation

Publish with us

Policies and ethics

Search

Navigation