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Biomaterials in Autoimmune Diseases

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Interaction of Nanomaterials With Living Cells

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Abstract

For a safe and efficient study of disease pathogenesis, biomaterials are utilized to treat tissue engineering and regeneration applications. Scientists have made an immense contribution to the stimulation of antigen-specific responses and the development of immunotherapeutics. One such disorder, e.g., autoimmune disease, needs to be controlled at molecular and cellular levels. Biomaterials have also been considered as means of delivering autoantigens or drugs for treating autoimmune disorders in a sustained and specific-release manner. However, their use has certain drawbacks, like the development of chronic inflammation, compatibility issues, etc. Despite these concerns, using biomaterials to engineer the immune system for various applications in the autoimmunity field is primarily considered beneficial. This chapter discusses how biomaterials have been planned for drug delivery and disease detection of autoimmune diseases. Biomaterials have also been engineered to treat autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, and type 1 diabetes, which are also discussed.

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References

  • Agusti A et al (2003) Hypothesis: does COPD have an autoimmune component? BMJ Publishing Group Ltd.

    Google Scholar 

  • Alijotas-Reig J (2015) Human adjuvant-related syndrome or autoimmune/inflammatory syndrome induced by adjuvants. Where have we come from? Where are we going? A proposal for new diagnostic criteria. Lupus 24(10):1012–1018

    Article  CAS  PubMed  Google Scholar 

  • Alijotas-Reig J et al (2012) Autoimmune/inflammatory syndrome (ASIA) induced by biomaterials injection other than silicone medical grade. Lupus 21(12):1326–1334

    Article  CAS  PubMed  Google Scholar 

  • Alkilany AM, Murphy CJ (2010) Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? J Nanopart Res 12(7):2313–2333

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Alkilany AM et al (2012) Gold nanorods: their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions. Adv Drug Deliv Rev 64(2):190–199

    Article  CAS  PubMed  Google Scholar 

  • Andrews SF, Wilson PC (2010) The anergic B cell. Blood 115(24):4976–4978

    Article  CAS  PubMed  Google Scholar 

  • Assaraf YG, Leamon CP, Reddy JA (2014) The folate receptor as a rational therapeutic target for personalized cancer treatment. Drug Resist Updat 17(4–6):89–95

    Article  PubMed  Google Scholar 

  • Banchereau J et al (2000) Immunobiology of dendritic cells. Annu Rev Immunol 18(1):767–811

    Article  CAS  PubMed  Google Scholar 

  • Bansal A, Sekhon JS, Verma S (2014) Scattering efficiency and LSPR tunability of bimetallic Ag, Au, and Cu nanoparticles. Plasmonics 9(1):143–150

    Article  CAS  Google Scholar 

  • Bluestone JA, Herold K, Eisenbarth G (2010) Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 464(7293):1293–1300

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Büyüktimkin B et al (2012) Vaccine-like controlled-release delivery of an immunomodulating peptide to treat experimental autoimmune encephalomyelitis. Mol Pharm 9(4):979–985

    Article  PubMed  PubMed Central  Google Scholar 

  • Cao X, Ye Y, Liu S (2011) Gold nanoparticle-based signal amplification for biosensing. Anal Biochem 417(1):1–16

    Article  CAS  PubMed  Google Scholar 

  • Carambia A et al (2015) Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice. J Hepatol 62(6):1349–1356

    Article  CAS  PubMed  Google Scholar 

  • Castro JE et al (1996) Fas modulation of apoptosis during negative selection of thymocytes. Immunity 5(6):617–627

    Article  CAS  PubMed  Google Scholar 

  • Chan AW, Neufeld RJ (2010) Tuneable semi-synthetic network alginate for absorptive encapsulation and controlled release of protein therapeutics. Biomaterials 31(34):9040–9047

    Article  CAS  PubMed  Google Scholar 

  • Chen Y-S et al (2009) Assessment of the in vivo toxicity of gold nanoparticles. Nanoscale Res Lett 4(8):858–864

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Choh S-Y, Cross D, Wang C (2011) Facile synthesis and characterization of disulfide-cross-linked hyaluronic acid hydrogels for protein delivery and cell encapsulation. Biomacromolecules 12(4):1126–1136

    Article  CAS  PubMed  Google Scholar 

  • Chou AI, Nicoll SB (2009) Characterization of photocrosslinked alginate hydrogels for nucleus pulposus cell encapsulation. J Biomed Mater Res A 91(1):187–194

    Article  PubMed  Google Scholar 

  • Clegg JR, Wechsler ME, Peppas NA (2017) Vision for functionally decorated and molecularly imprinted polymers in regenerative engineering. Regen Eng Transl Med 3(3):166–175

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Convertine AJ et al (2009) Development of a novel endosomolytic diblock copolymer for siRNA delivery. J Control Release 133(3):221–229

    Article  CAS  PubMed  Google Scholar 

  • Correale J, Farez M, Gilmore W (2008) Vaccines for Multiple sclerosis. CNS Drugs 22(3):175–198

    Article  CAS  PubMed  Google Scholar 

  • Daniels TR et al (2006) The transferrin receptor part I: biology and targeting with cytotoxic antibodies for the treatment of cancer. Clin Immunol 121(2):144–158

    Article  CAS  PubMed  Google Scholar 

  • Desgrosellier JS, Cheresh DA (2010) Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 10(1):9–22

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dickerson EB et al (2008) Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice. Cancer Lett 269(1):57–66

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • El-Kamel A et al (2001) Preparation and evaluation of ketoprofen floating oral delivery system. Int J Pharm 220(1–2):13–21

    Article  CAS  PubMed  Google Scholar 

  • Ferrara N, Hillan KJ, Novotny W (2005) Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy. Biochem Biophys Res Commun 333(2):328–335

    Article  CAS  PubMed  Google Scholar 

  • Forrester JV et al (2008) Immune privilege or privileged immunity? Mucosal Immunol 1(5):372–381

    Article  CAS  PubMed  Google Scholar 

  • Foster GA et al (2017) Protease-degradable microgels for protein delivery for vascularization. Biomaterials 113:170–175

    Article  CAS  PubMed  Google Scholar 

  • França DCC, de Castro AL, Soubhia AMP (2013) Evaluation of the biocompatibility of silicone gel implants–histomorphometric study. Acta Inform Med 21(2):93

    Article  PubMed  PubMed Central  Google Scholar 

  • Gabriel SE et al (1994) Risk of connective-tissue diseases and other disorders after breast implantation. N Engl J Med 330(24):1697–1702

    Article  CAS  PubMed  Google Scholar 

  • Getts DR et al (2012) Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis. Nat Biotechnol 30(12):1217–1224

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Goren I, Segal G, Shoenfeld Y (2015) Autoimmune/inflammatory syndrome induced by adjuvant (ASIA) evolution after silicone implants. Who is at risk? Clin Rheumatol 34(10):1661–1666

    Article  PubMed  Google Scholar 

  • Hajdu SD, Agmon-Levin N, Shoenfeld Y (2011) Silicone and autoimmunity. Eur J Clin Investig 41(2):203–211

    Article  CAS  Google Scholar 

  • Higa LH et al (2017) Ultra-small solid archaeolipid nanoparticles for active targeting to macrophages of the inflamed mucosa. Nanomedicine 12(10):1165–1175

    Article  CAS  PubMed  Google Scholar 

  • Hölmich LR et al (2007) Breast implant rupture and connective tissue disease: a review of the literature. Plast Reconstr Surg 120(7):62S–69S

    Article  PubMed  Google Scholar 

  • Hoveizi E, Tavakol S, Ebrahimi-Barough S (2015) Neuroprotective effect of transplanted neural precursors embedded on PLA/CS scaffold in an animal model of multiple sclerosis. Mol Neurobiol 51(3):1334–1342

    Article  CAS  PubMed  Google Scholar 

  • Hu Q, Katti PS, Gu Z (2014) Enzyme-responsive nanomaterials for controlled drug delivery. Nanoscale 6(21):12273–12286

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hunter Z et al (2014) A biodegradable nanoparticle platform for the induction of antigen-specific immune tolerance for treatment of autoimmune disease. ACS Nano 8(3):2148–2160

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hwang J et al (2008) α-Methylprednisolone conjugated cyclodextrin polymer-based nanoparticles for rheumatoid arthritis therapy. Int J Nanomedicine 3(3):359

    CAS  PubMed  PubMed Central  Google Scholar 

  • Jain RK et al (2006) Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 3(1):24–40

    Article  CAS  PubMed  Google Scholar 

  • Jiang HH et al (2011) PEGylated TNF-related apoptosis-inducing ligand (TRAIL) for effective tumor combination therapy. Biomaterials 32(33):8529–8537

    Article  CAS  PubMed  Google Scholar 

  • Kapoor B et al (2014) Application of liposomes in treatment of rheumatoid arthritis: quo vadis. Sci World J 2014:978351

    Article  Google Scholar 

  • Kim WU et al (2002) Suppression of collagen-induced arthritis by single administration of poly (lactic-co-glycolic acid) nanoparticles entrapping type II collagen: a novel treatment strategy for induction of oral tolerance. Arthritis Rheum 46(4):1109–1120

    Article  CAS  PubMed  Google Scholar 

  • Kim D, Daniel WL, Mirkin CA (2009) Microarray-based multiplexed scanometric immunoassay for protein cancer markers using gold nanoparticle probes. Anal Chem 81(21):9183–9187

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kim TH et al (2011) PEGylated TNF-related apoptosis-inducing ligand (TRAIL)-loaded sustained release PLGA microspheres for enhanced stability and antitumor activity. J Control Release 150(1):63–69

    Article  CAS  PubMed  Google Scholar 

  • Kumagai Y et al (1984) Clinical spectrum of connective tissue disease after cosmetic surgery. Arthritis Rheum 27(1):1–12

    Article  CAS  PubMed  Google Scholar 

  • Lasagna-Reeves C et al (2010) Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice. Biochem Biophys Res Commun 393(4):649–655

    Article  CAS  PubMed  Google Scholar 

  • Le Droumaguet B et al (2012) Versatile and efficient targeting using a single nanoparticulate platform: application to cancer and Alzheimer’s disease. ACS Nano 6(7):5866–5879

    Article  PubMed  Google Scholar 

  • Lee W-K et al (2005) Preparation and characterization of biodegradable nanoparticles entrapping immunodominant peptide conjugated with PEG for oral tolerance induction. J Control Release 105(1–2):77–88

    Article  CAS  PubMed  Google Scholar 

  • Lehuen A et al (2010) Immune cell crosstalk in type 1 diabetes. Nat Rev Immunol 10(7):501–513

    Article  CAS  PubMed  Google Scholar 

  • Lewis JS, Roy K, Keselowsky BG (2014) Materials that harness and modulate the immune system. MRS Bull 39(1):25–34

    Article  PubMed  PubMed Central  Google Scholar 

  • Liang LS et al (2004) Methotrexate loaded poly (L-lactic acid) microspheres for intra-articular delivery of methotrexate to the joint. J Pharm Sci 93(4):943–956

    Article  CAS  PubMed  Google Scholar 

  • Liechty WB, Scheuerle RL, Peppas NA (2013) Tunable, responsive nanogels containing t-butyl methacrylate and 2-(t-butylamino) ethyl methacrylate. Polymer 54(15):3784–3795

    Article  CAS  Google Scholar 

  • Liu D et al (2010) Solid lipid nanoparticles for transdermal delivery of diclofenac sodium: preparation, characterization and in vitro studies. J Microencapsul 27(8):726–734

    Article  CAS  PubMed  Google Scholar 

  • Loyo E et al (2013) Autoimmunity in connection with a metal implant: a case of autoimmune/autoinflammatory syndrome induced by adjuvants. Autoimmun Highlights 4(1):33–38

    Article  Google Scholar 

  • Lv S et al (2014) Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer. Biomaterials 35(23):6118–6129

    Article  CAS  PubMed  Google Scholar 

  • Mahato R, Tai W, Cheng K (2011) Prodrugs for improving tumor targetability and efficiency. Adv Drug Deliv Rev 63(8):659–670

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Maldonado RA et al (2015) Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance. Proc Natl Acad Sci 112(2):E156–E165

    Article  CAS  PubMed  Google Scholar 

  • Mane V, Muro S (2012) Biodistribution and endocytosis of ICAM-1-targeting antibodies versus nanocarriers in the gastrointestinal tract in mice. Int J Nanomedicine 7:4223

    CAS  PubMed  PubMed Central  Google Scholar 

  • McRae Page S et al (2013) Disulfide cross-linked phosphorylcholine micelles for triggered release of camptothecin. Mol Pharm 10(7):2684–2692

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Moriuchi-Murakami E et al (2000) Treatment of established collagen induced arthritis with prostaglandin E1 incorporated in lipid microspheres. J Rheumatol 27(10):2389–2396

    CAS  PubMed  Google Scholar 

  • Nesher G et al (2015) Severe ASIA syndrome associated with lymph node, thoracic, and pulmonary silicone infiltration following breast implant rupture: experience with four cases. Lupus 24(4–5):463–468

    Article  CAS  PubMed  Google Scholar 

  • Nicholas D, Odumosu O, Langridge WH (2011) Autoantigen based vaccines for type 1 diabetes. Discov Med 11(59):293

    PubMed  PubMed Central  Google Scholar 

  • Nicodemus GD, Bryant SJ (2008) Cell encapsulation in biodegradable hydrogels for tissue engineering applications. Tissue Eng Part B Rev 14(2):149–165

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nossal G (1994) Negative selection of lymphocytes. Cell 76(2):229–239

    Article  CAS  PubMed  Google Scholar 

  • Owens DE III et al (2007) Temperature-responsive polymer–gold nanocomposites as intelligent therapeutic systems. J Biomed Mater Res A 83(3):692–695

    Article  PubMed  Google Scholar 

  • Patenaude M, Hoare T (2012) Injectable, mixed natural-synthetic polymer hydrogels with modular properties. Biomacromolecules 13(2):369–378

    Article  CAS  PubMed  Google Scholar 

  • Peppas N, Kim B (2006) Stimuli-sensitive protein delivery systems. J Drug Deliv Sci Technol 16(1):11–18

    Article  CAS  Google Scholar 

  • Periasamy AP, Chang Y-J, Chen S-M (2011) Amperometric glucose sensor based on glucose oxidase immobilized on gelatin-multiwalled carbon nanotube modified glassy carbon electrode. Bioelectrochemistry 80(2):114–120

    Article  CAS  PubMed  Google Scholar 

  • Petryayeva E, Krull UJ (2011) Localized surface plasmon resonance: nanostructures, bioassays and biosensing—a review. Anal Chim Acta 706(1):8–24

    Article  CAS  PubMed  Google Scholar 

  • Rodell CB et al (2015) Selective proteolytic degradation of guest–host assembled, injectable hyaluronic acid hydrogels. ACS Biomater Sci Eng 1(4):277–286

    Article  CAS  PubMed  Google Scholar 

  • Rosenthal KS et al (2015) Rheumatoid arthritis vaccine therapies: perspectives and lessons from therapeutic ligand epitope antigen presentation system vaccines for models of rheumatoid arthritis. Expert Rev Vaccines 14(6):891–908

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sanchez-Guerrero J et al (1995) Silicone breast implants and the risk of connective-tissue diseases and symptoms. N Engl J Med 332(25):1666–1670

    Article  CAS  PubMed  Google Scholar 

  • Sekhon JS, Verma S (2011) Refractive index sensitivity analysis of Ag, Au, and Cu nanoparticles. Plasmonics 6(2):311–317

    Article  CAS  Google Scholar 

  • Shodeinde AB et al (2020) Recent advances in smart biomaterials for the detection and treatment of autoimmune diseases. Adv Funct Mater 30(37):1909556

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Singh S et al (2009) Enhanced transdermal delivery of ketoprofen from bioadhesive gels. Pak J Pharm Sci 22(2)

    Google Scholar 

  • Singh M et al (2016) Silicone-induced granuloma after buttock augmentation. Plast Reconstr Surg Glob Open 4(2)

    Google Scholar 

  • Sionkowska A (2011) Current research on the blends of natural and synthetic polymers as new biomaterials. Prog Polym Sci 36(9):1254–1276

    Article  CAS  Google Scholar 

  • Soehngen EC et al (1988) Encapsulation of indomethacin in liposomes provides protection against both gastric and intestinal ulceration when orally administered to rats. Arthritis Rheum 31(3):414–422

    Article  CAS  PubMed  Google Scholar 

  • Sonawane ND, Szoka FC Jr, Verkman A (2003) Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J Biol Chem 278(45):44826–44831

    Article  CAS  PubMed  Google Scholar 

  • Spiera R, Gibofsky A, Spiera H (1994) Silicone gel filled breast implants and connective tissue disease: an overview. J Rheumatol 21(2):239–245

    CAS  PubMed  Google Scholar 

  • Su K-H et al (2003) Interparticle coupling effects on plasmon resonances of nanogold particles. Nano Lett 3(8):1087–1090

    Article  CAS  Google Scholar 

  • Suda K et al (2016) Deterioration of autoimmune condition associated with repeated injection of dextranomer/hyaluronic acid copolymer: a case report. J Pediatr Surg Case Rep 4:10–12

    Article  Google Scholar 

  • Tacchini L et al (2008) Role of HIF-1 and NF-κB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals. J Biol Chem 283(30):20674–20686

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tai W, Mahato R, Cheng K (2010) The role of HER2 in cancer therapy and targeted drug delivery. J Control Release 146(3):264–275

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tang L-Y et al (2009) Shell-detachable micelles based on disulfide-linked block copolymer as potential carrier for intracellular drug delivery. Bioconjug Chem 20(6):1095–1099

    Article  CAS  PubMed  Google Scholar 

  • Tirosh B et al (2009) Transferrin as a luminal target for negatively charged liposomes in the inflamed colonic mucosa. Mol Pharm 6(4):1083–1091

    Article  CAS  PubMed  Google Scholar 

  • Truong VX et al (2015) Simultaneous orthogonal dual-click approach to tough, in-situ-forming hydrogels for cell encapsulation. J Am Chem Soc 137(4):1618–1622

    Article  CAS  PubMed  Google Scholar 

  • Ulbrich K et al (2016) Targeted drug delivery with polymers and magnetic nanoparticles: covalent and noncovalent approaches, release control, and clinical studies. Chem Rev 116(9):5338–5431

    Article  CAS  PubMed  Google Scholar 

  • Unnikrishnan B, Palanisamy S, Chen S-M (2013) A simple electrochemical approach to fabricate a glucose biosensor based on graphene–glucose oxidase biocomposite. Biosens Bioelectron 39(1):70–75

    Article  CAS  PubMed  Google Scholar 

  • Utech S et al (2015) Supplementary data for article: Utech, S.; Prodanovic, R.; Mao, AS; Ostafe, R.; Mooney, DJ; Weitz, DA Microfluidic Generation of Monodisperse, Structurally Homogeneous Alginate Microgels for Cell Encapsulation and 3D Cell Culture. Adv Healthc Mater 4(11):1628–1633. https://doi.org/10.1002/adhm.201500021. Advanced Healthcare Materials, 2015

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Van Belle TL, Coppieters KT, Von Herrath MG (2011) Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev 91(1):79–118

    Article  PubMed  Google Scholar 

  • Van de Broek B et al (2011) Specific cell targeting with nanobody conjugated branched gold nanoparticles for photothermal therapy. ACS Nano 5(6):4319–4328

    Article  PubMed  Google Scholar 

  • Van Nunen SA, Gatenby PA, Basten A (1982) Post-mammoplasty connective tissue disease. Arthritis Rheum 25(6):694–697

    Article  PubMed  Google Scholar 

  • Vannucci L et al (2012) Selective targeting of melanoma by PEG-masked protein-based multifunctional nanoparticles. Int J Nanomedicine 7:1489

    CAS  PubMed  PubMed Central  Google Scholar 

  • Venkatesh S et al (2005) Applications of biomimetic systems in drug delivery. Expert Opin Drug Deliv 2(6):1085–1096

    Article  CAS  PubMed  Google Scholar 

  • Verbeke CS et al (2017) Multicomponent Injectable Hydrogels for Antigen-Specific Tolerogenic Immune Modulation. Adv Healthc Mater 6(6):1600773

    Article  Google Scholar 

  • von Boehmer H (1990) Developmental biology of T cells in T cell-receptor transgenic mice. Annu Rev Immunol 8(1):531–556

    Article  Google Scholar 

  • Wang Q et al (2011) PLGA-chitosan/PLGA-alginate nanoparticle blends as biodegradable colloidal gels for seeding human umbilical cord mesenchymal stem cells. J Biomed Mater Res A 96(3):520–527

    Article  PubMed  PubMed Central  Google Scholar 

  • Xiong W et al (2011) Dual temperature/pH-sensitive drug delivery of poly (N-isopropylacrylamide-co-acrylic acid) nanogels conjugated with doxorubicin for potential application in tumor hyperthermia therapy. Colloids Surf B: Biointerfaces 84(2):447–453

    Article  CAS  PubMed  Google Scholar 

  • Yang F, Kamiya N, Goto M (2012) Transdermal delivery of the anti-rheumatic agent methotrexate using a solid-in-oil nanocarrier. Eur J Pharm Biopharm 82(1):158–163

    Article  CAS  PubMed  Google Scholar 

  • Yarkoni Y, Getahun A, Cambier JC (2010) Molecular underpinning of B-cell anergy. Immunol Rev 237(1):249–263

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yeste A et al (2012) Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis. Proc Natl Acad Sci 109(28):11270–11275

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yoon YM et al (2015) A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice. Sci Rep 5(1):1–13

    Article  CAS  Google Scholar 

  • Zeng S et al (2011) A review on functionalized gold nanoparticles for biosensing applications. Plasmonics 6(3):491–506

    Article  CAS  Google Scholar 

  • Zhang H et al (2015) A new comonomer design for enhancing the pH-triggered LCST shift of thermosensitive polymers. Polym Chem 6(37):6644–6650

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Cellular Signalling Laboratory, Department of Nanotechnology, University of Kashmir Hazratbal, Srinagar, Jammu and Kashmir, India

    Iqra Jan, Asma Rafiq, Mehvish Ali & Sabreena Aashaq

  2. Department of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India

    Sabreena Aashaq

  3. Department of Biotechnology, University of Kashmir Hazratbal, Srinagar, Jammu and Kashmir, India

    Bilal A. Reshi

  4. Nanostructured and Biomimetic Lab, Department of Nanotechnology, University of Kashmir Hazratbal, Srinagar, Jammu and Kashmir, India

    Faheem A. Sheikh

  5. Laboratory for Multifunctional Nanomaterials, Department of Nanotechnology, University of Kashmir Hazratbal, Srinagar, Jammu and Kashmir, India

    Shafquat Majeed

  6. Cellular Signalling and Nanotherapeutics Laboratory, Department of Nanotechnology, University of Kashmir Hazratbal, Srinagar, Jammu and Kashmir, India

    Mushtaq A. Beigh

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  1. Iqra Jan
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  2. Asma Rafiq
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  3. Mehvish Ali
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  6. Faheem A. Sheikh
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Correspondence to Mushtaq A. Beigh .

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  1. Department of Nanotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India

    Faheem Arjamend Sheikh

  2. Department of Nanotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India

    Shafquat Majeed

  3. Department of Nanotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India

    Mushtaq A. Beigh

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Jan, I. et al. (2023). Biomaterials in Autoimmune Diseases. In: Sheikh, F.A., Majeed, S., Beigh, M.A. (eds) Interaction of Nanomaterials With Living Cells. Springer, Singapore. https://doi.org/10.1007/978-981-99-2119-5_30

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