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Hepatitis E Virus Life Cycle

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Hepatitis E Virus

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1417))

Abstract

Hepatitis E virus (HEV) infects over 20 million people worldwide per year, leading to 30,000–40,000 deaths. In most cases HEV infection in a self-limited, acute illness. However, chronic infections could occur in immunocompromised individuals. Due to scarcity of robust cell culture models in vitro and genetic tractable animal models in vivo, the details of HEV life cycle, as well as its interaction with host cells still remain elusive, which dampens antivirals discovery. In this chapter, we present an update in the HEV infectious cycle steps: entry, genome replication/subgenomic RNA transcription, assembly, and release. Moreover, we discussed the future prospective on HEV research and illustrates important questions urgently to be addressed.

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Abbreviations

ALF:

Acute liver failure

CRISPR:

Clustered regularly interspaced short palindromic repeats

eHEV:

enveloped HEV

ELISA:

Enzyme-linked immunosorbent assay

ESCRT:

Endosomal sorting complexes required for transport

GOF:

Gain of function

GTP:

Guanosine triphosphate

HA:

Hemagglutinin

Hel:

Helicase

HEV:

Hepatitis E virus

HVR:

Proline-rich hypervariable region

LOF:

Loss of function

mAb:

Monoclonal antibody

MeT:

Methyltransferase

MVBs:

Multivesicular bodies

neHEV:

nonenveloped HEV

ORFs:

Open reading frames

PCP:

Papain-like cysteine protease

RdRp:

RNA-dependent RNA polymerase

SDS-PAGE:

Sodium dodecyl sulfate–polyacrylamide gel electrophoresis

UTR:

Untranslated region

VLPs:

Virus-like particles

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  1. School of Medicine, Tsinghua University, Beijing, China

    Xiaohui Ju, Lin Dong & Qiang Ding

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    Youchun Wang

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Ju, X., Dong, L., Ding, Q. (2023). Hepatitis E Virus Life Cycle. In: Wang, Y. (eds) Hepatitis E Virus. Advances in Experimental Medicine and Biology, vol 1417. Springer, Singapore. https://doi.org/10.1007/978-981-99-1304-6_10

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