Stem Cell-Based Regeneration of Salivary Glands: From Bench to Clinics

Upadhyay, Akshaya; Cao, Uyen; Cai, Wenji; Alli, Babatunde; Khayambashi, Parisa; Mai, Crystal To Tam; Sultan, Stephanie; Tran, Simon D.

doi:10.1007/978-981-99-0846-2_52-2

Akshaya Upadhyay²,
Uyen Cao²,
Wenji Cai²,
Babatunde Alli²,
Parisa Khayambashi²,
Crystal To Tam Mai²,
Stephanie Sultan³ &
…
Simon D. Tran⁴

2 Accesses

Abstract

Exocrine gland regeneration, particularly salivary gland regeneration, remains an exciting arena for the scientific world due to its crucial role in maintaining human health. Salivary gland cells produce saliva, which lubricates the oral cavity, maintains the pH, partially or wholly digests complex nutrients, and provides the first line of defense against pathogens. Thus, its damage can be debilitating to the oral as well as the general health of an individual, compromising their quality of life. Most commonly, this impairment is due to autoimmune diseases such as Sjogren’s syndrome or off-target radiation effects during radiotherapy, where the dry mouth condition clinically can be 100% in these patients, with an average prevalence of 64.8% of the whole population. This chapter combines the latest theories and proof of concepts for salivary gland regeneration using stem cells and their secretome. Also, this chapter describes various stem cells’ derivation and characterization, followed by a comprehensive discussion of the latest salivary gland regenerative strategies being tested in preclinical and clinical studies.

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Abbreviations

ANKRD56:: Ankyrin repeat domain-containing protein
ANXA1:: Annexin A1
AQP5:: Aquaporin 5
CCL2:: C-C motif chemokine ligand 2
c-Myc:: Cellular-master regulator of cell cycle entry and proliferative
CYP11A1:: Cytochrome P450 family 11 subfamily A member 1
DPSC:: Dental pulp stem cells
HAPLN1:: Hyaluronan and proteoglycan link protein
HES1:: Hes family BHLH transcription factor 1
HMG20B:: High mobility group 20B
IRF6:: Interferon regulatory factor 6
Klf4:: Krüppel-like factor 4
LUM:: Lumican
MSX2:: Msh homeobox 2
OCN:: Osteocalcin
Oct3/4:: Octamer-binding transcription factor
PSP:: Parotid secretory protein
SABPA:: Salivary androgen-binding protein
SGSPC:: Salivary gland stem and progenitor cells
SMA-α:: Alpha smooth muscle actin
Sox2/9:: SRY-related SMG box 2/9
TCF3:: Transcription factor 3
TGFβ:: Transforming growth factor β

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McGill University, Montreal, Montreal, QC, Canada
Akshaya Upadhyay, Uyen Cao, Wenji Cai, Babatunde Alli, Parisa Khayambashi & Crystal To Tam Mai
McGill University Health Center, Montreal, QC, Canada
Stephanie Sultan
Craniofacial Stem Cells and Tissue Engineering Laboratory, McGill University, Montreal, QC, Canada
Simon D. Tran

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Akshaya Upadhyay
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Wenji Cai
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Babatunde Alli
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Khawaja H. Haider

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Upadhyay, A. et al. (2024). Stem Cell-Based Regeneration of Salivary Glands: From Bench to Clinics. In: Haider, K.H. (eds) Handbook of Stem Cell Applications. Springer, Singapore. https://doi.org/10.1007/978-981-99-0846-2_52-2

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DOI: https://doi.org/10.1007/978-981-99-0846-2_52-2
Received: 22 February 2023
Accepted: 11 April 2023
Published: 23 April 2024
Publisher Name: Springer, Singapore
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Stem Cell-Based Regeneration of Salivary Glands: From Bench to Clinics

Published:

23 April 2024

DOI: https://doi.org/10.1007/978-981-99-0846-2_52-2
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Stem Cell-Based Regeneration of Salivary Glands: From Bench to Clinics

Published:

11 August 2023

DOI: https://doi.org/10.1007/978-981-99-0846-2_52-1