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Functionalized Mesoporous Silica-Based Nanoparticles for Theranostic Applications

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Multifunctional And Targeted Theranostic Nanomedicines

Abstract

Mesoporous silica nanoparticles (MSNs) have gained huge attention among scientific groups by virtue of its distinct features. The monodispersity nature, tunable pore size, and surface engineering made it versatile nanocarriers in the field of pharmaceutical sciences and biomedical arena. MSNs have been exploited in bio-imaging by means of its greater stability and inherent photoluminescence features. Apart from bio-imaging, smart stimuli-responsive nanomaterials have been explored in the management of several devastating diseases specifically cancers and neurological disorders. The applicability of surface-modified MSNs provides the site-specific targeting while reducing the off-target noxious effects. The current chapter majorly covers the MSN-mediated nanotechnological approaches to showcase the significant theranostic applications.

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Abbreviations

5-FU:

5-Fluorouracil

AMF:

Alternating magnetic field

APTES:

(3-Aminopropyl) triethoxysilane

ATO:

Arsenic trioxide

ATP:

Adenosine tri-phosphate

CAP:

Capecitabine

CMC:

Critical micelle concentration

CTAB:

Cetyl trimethyl ammonium bromide

DDS:

Drug delivery systems

DNA:

Deoxyribonucleic acid

DOX:

Doxorubicin

EphA2:

Ephrin type-A receptor 2

EPR:

Enhanced permeability and retention

FA:

Folic acid

GEM:

Gemcitabine

HCC:

Hepatocellular cancer

LCST:

Lower critical solution temperature

MDR:

Multidrug resistance

MSNs:

Mesoporous silica nanoparticles

NIR:

Near infrared

O/W:

Oil in water

ORMOSIL:

Organically modified silica

PLAA:

Phospholipase A2 activating protein

PMO:

Periodic mesoporous organosilica

PNIPAM:

Poly(N-isopropylacrylamide)

PSMA:

Anti-prostrate-specific membrane antigen

RNA:

Ribonucleic acid

ROS:

Reactive oxygen species

SBA:

Santa Barbara Amorphous

TAT:

Trans-activator of transcription

TEOS:

Tetraethyl orthosilicate

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Authors and Affiliations

  1. Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Ajmer, Rajasthan, India

    Ujwala Ramteke, Vinay Kumar, Sanya Batheja, Ganesh Phulmogare & Umesh Gupta

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  1. Ujwala Ramteke
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  2. Vinay Kumar
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  3. Sanya Batheja
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  4. Ganesh Phulmogare
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  5. Umesh Gupta
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Correspondence to Umesh Gupta .

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Editors and Affiliations

  1. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) – Raebareli, Lucknow, India

    Keerti Jain

  2. Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradesh, India

    N. K. Jain

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Ramteke, U., Kumar, V., Batheja, S., Phulmogare, G., Gupta, U. (2023). Functionalized Mesoporous Silica-Based Nanoparticles for Theranostic Applications. In: Jain, K., Jain, N.K. (eds) Multifunctional And Targeted Theranostic Nanomedicines. Springer, Singapore. https://doi.org/10.1007/978-981-99-0538-6_16

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  • DOI: https://doi.org/10.1007/978-981-99-0538-6_16

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