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Stimuli-Sensitive Polymeric Micelles for Biomedical Applications

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Polymeric Micelles: Principles, Perspectives and Practices

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Abstract

Stimuli-responsive polymeric micelles (PMs) have emerged not only as a promising technology to achieve on-demand, targeted, and regulated drug release for therapeutic applications but also for diagnostic purposes, emerging collectively as a theranostic toolkit. The stimuli can be exogenous (extrinsic) such as light, temperature, ultrasound, electric and magnetic field, or endogenous (intrinsic) such as pH, glucose, reactive oxygen species, redox, hypoxia, and enzymes. Stimuli-responsive PMs find extensive application in the field of cancer research. Tumor cells as well as tumor sites undergo extensive changes during their development and progression including the accumulation of acidic metabolites which reduces their pH in comparison to normal tissues, the elevation of several enzymes as well as proteins, increased reactive oxygen species, reduced oxygen levels, altered redox potential in certain tumor tissues, and increased temperature around certain tumor sites. These unique features encourage the development and fabrication of stimuli-responsive systems. In addition, these systems can also be engineered to encapsulate a wide variety of bioactive molecules and tuned in a way to overcome biological barriers by external stimuli to improve the efficiency of accumulation at the target site or within the tumor cells. In recent years stimuli-responsive systems are capturing the attention in research on the controlled delivery of drugs. In this review, an emphasis on the recent developments of the external, internal, dual and multi-stimuli-responsive polymeric micelles is made along with its future perspectives.

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Authors and Affiliations

  1. Industrial Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science (BITS)—Pilani, Pilani, Rajasthan, India

    Kaushal K. Jain, Akanksha Yogesh Kadam, Yashika Tomar & Gautam Singhvi

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  1. Kaushal K. Jain
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  2. Akanksha Yogesh Kadam
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  3. Yashika Tomar
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  4. Gautam Singhvi
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Correspondence to Gautam Singhvi .

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Editors and Affiliations

  1. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

    Sachin Kumar Singh

  2. School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar, Punjab, India

    Monica Gulati

  3. Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India

    Srinivas Mutalik

  4. Harrison School of Pharmacy, Auburn University, Auburn, AL, USA

    Muralikrishnan Dhanasekaran

  5. Discipline of Pharmacy, University of Technology Sydney, Sydney, NSW, Australia

    Kamal Dua

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Jain, K.K., Kadam, A.Y., Tomar, Y., Singhvi, G. (2023). Stimuli-Sensitive Polymeric Micelles for Biomedical Applications. In: Singh, S.K., Gulati, M., Mutalik, S., Dhanasekaran, M., Dua, K. (eds) Polymeric Micelles: Principles, Perspectives and Practices. Springer, Singapore. https://doi.org/10.1007/978-981-99-0361-0_7

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