Overview
- Nominated as an outstanding Ph.D. thesis by Kyoto University
- Provides detailed introduction of the properties of cyclobutene and medium-sized trans-cycloalkene
- Explains detailed principle and provides a brief review of 4π-electrocyclic reaction
Part of the book series: Springer Theses (Springer Theses)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (6 chapters)
-
Front Matter
Keywords
About this book
This book explains the existence of the intermediate using two approaches: computational chemistry and coordination chemistry. In this book, the author has developed new methods for synthesizing medium-sized cycloalkenes by utilizing the 4π-electrocyclic reaction of fused-cyclobutenes. The fundamental and most important strategy and feature of the work are as follows: first, cyclobutene is used as a readily available raw material with high-strain energy to generate more strained medium-sized cis,trans-cycloalkadiene molecules. Second, by judiciously selecting the reaction conditions, the short-lived intermediate (medium-sized cis,trans-cycloalkadiene) can be converted to medium-sized cis- or trans-cycloalkenes. For the former, the generation of the medium-sized cis,trans-cycloalkadiene intermediate is greatly affected by the substituent on the cyclobutene, and there are few examples of its generation confirmed at room temperature. Regarding the latter, the synthesis of trans-cycloalkenes is noteworthy in terms of establishing a new synthetic methodology and providing one of the few asymmetric synthesis methods, which has not been achieved before. Readers of this book can gain novel insights into strained molecules involved not only in small-sized cycloalkenes but also in medium-sized ones.
Authors and Affiliations
About the author
Dr. Tomohiro is a researcher at the Department of Chemical Process Research and Development in ONO PHARMACEUTICAL CO., LTD. The author started his academic career as an undergraduate school student at the Department of Hospital Pharmacy at the University of Toyama and engaged in the discovery of hyaluronidase inhibitors from traditional plants. The author moved to Kyoto University and got his Ph.D. under the supervision of Dr. Kiyosei Takasu with the thesis titled, 'Synthetic Utility of Fused-Cyclobutenes: Synthesis of Medium-Sized Cycloalkenes.' The author’s current interest is focused on greenery, cost-effective, and safe production of active pharmaceutical ingredients on an industrial scale.
Bibliographic Information
Book Title: Synthesis of Medium-Sized Cycloalkenes via Fused-Cyclobutenes
Authors: Tomohiro Ito
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-981-97-0787-4
Publisher: Springer Singapore
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024
Hardcover ISBN: 978-981-97-0786-7Published: 06 April 2024
Softcover ISBN: 978-981-97-0789-8Due: 13 May 2024
eBook ISBN: 978-981-97-0787-4Published: 05 April 2024
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XII, 129
Number of Illustrations: 137 b/w illustrations, 25 illustrations in colour
Topics: Organic Chemistry, Chemistry/Food Science, general, Medicinal Chemistry, Pharmacology/Toxicology