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Animal Models in Sleep Research

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Animal Models in Research

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Abstract

Sleep is an integral and indispensable part of life in the animal kingdom. In the current world of 24 × 7, loaded with digital technologies, there are growing concerns about decreasing sleep quality and quantity and its effect on health. Sleep studies in animal models have offered enormous insight into the sleep regulation process; nonetheless, much more research is needed. Animals serve as an important experimental model for sleep studies because experiments on controlled sleep deprivation cannot be conducted in humans due to ethical constraints. As the techniques employed in these studies may not be familiar to all, this chapter will detail the procedures adopted for performing implantation of electrodes for sleep recording, in the rat model. Along with that, relevant methods that may assist new laboratories in establishing animal sleep laboratories are showcased. These will also provide the necessary knowledge for examining its relation with cognition and other functions to investigate the cellular/genetic basis of linked disorders.

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Acknowledgments

The author acknowledges the Sree Chitra Tirunal Institute for Medical Sciences and Technology for providing the in-house grant for establishing the Sleep Research facility in 2010, and the extra-mural grants for further research studies from the Cognitive Science Research Initiation program of the Department of Science and Technology, India (SR/CSI/110/2012 and SR/CSRI/102/2014). KKG expresses special gratitude to Prof. V. Mohan Kumar for making this state-of-the-art facility possible in Kerala.

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Authors and Affiliations

  1. Division of Sleep Research, Department of Applied Biology, BioMedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India

    Kamalesh K. Gulia

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  1. Kamalesh K. Gulia
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Correspondence to Kamalesh K. Gulia .

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Editors and Affiliations

  1. Laboratory Animal Science Division, Sree Chitra Tirunal Institute for Medical Sciences & Technology, BioMedical Technology Wing, Thiruvananthapuram, Kerala, India

    Harikrishnan Vijayakumar Sreelatha

  2. Animal Research Facilities, Zydus Lifesciences Ltd, Ahmedabad, Gujarat, India

    Satish Patel

  3. Experimental Animal Facility, National Institute of Immunology, New Delhi, Delhi, India

    Perumal Nagarajan

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Gulia, K.K. (2024). Animal Models in Sleep Research. In: Vijayakumar Sreelatha, H., Patel, S., Nagarajan, P. (eds) Animal Models in Research. Springer, Singapore. https://doi.org/10.1007/978-981-97-0048-6_12

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