Abstract
Lung cancer is a chronic disease and speaks to one of the greatest health care issues for mankind. It is an illness with a high morbidity and high demise rates. Subsequently, it is regularly connected with a plenty of affliction and general abatement in the quality of life. Just chemotherapy and radiation therapies are now and again effective and in much occasions harmful and deadly. Alternative and less toxic medicine is very considerably essential to this ailment. The goal of this study is to review the medicinal plants having antitumor activity for the management of lung cancer. Medicinal plants are presently standing out as likely wellsprings of anticancer specialists and are broadly utilized because of accessibility of the materials, generally modest, little, or no side effects, wide pertinence, and helpful adequacy which thus have quickened the scientific exploration. The study was directed with lung cancer cell line (Human), on humans and animals, and lung carcinoma (Lewis) was the maximum utilized exploratory model. In this review we have summarized some medicinal plants keep being an abundant wellspring of herbal remedies or bioactive composites against Lung cancer.
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References
American Cancer Society (2010) Cancer facts & figures. American Cancer Society, Atlanta
Luo J, Solimini NL, Elledge SJ (2009) Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 136:823–837
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674
Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70
Kashfi K (2013) Dysfunctional cell signaling dynamics in oncology: diagnostic, prognostic and treatment opportunities. Biochem Pharmacol 85:595–596
Alwan A, Maclean DR, Riley LM, d'Espaignet ET, Mathers CD, Stevens GA, Bettcher D (2010) Monitoring and surveillance of chronic non-communicable diseases: progress and capacity in high-burden countries. Lancet 376:1861–1868
CDC—Global Cancer Statistics. http://www.cdc.gov/cancer/international/statistics.htm. Accessed 21 Jan 2016
Ford DW, Koch KA, Ray DE, Selecky PA (2013) Palliative and end-of-life care in lung cancer. Chest 143(5 Suppl):498S–512S
GBD 2015 Risk Factors Collaborators (2016) Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the global burden of disease study 2015. Lancet 388(10053):1659–1724
Alberg AJ, Brock MV, Ford JG, Samet JM, Spivack SD (2013) Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 143:1–29
Rom WN, Hay JG, Lee TC, Jiang Y (2000) Molecular and genetic aspects of lung cancer. Am J Respir Crit Care Med 16:1355–1367
Duarte RLM, Paschoal MEM (2005) Marcadores moleculares no câncer de pulmão: papel prognóstico e sua relação com o tabagismo. J Braz Pneumol 32:56–65
Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ, Thun MJ (2005) Cancer statistics, 2005. Cancer J Clin 55:10–30
Robert JC (2002) Lung cancer: a review. Am J Health-Syst Pharm 59(1):611–642
Rowlands MA, Gunnell D, Harris R, Vatten LJ, Holly JMP, Martin RM (2009) Circulating insulin-like growth factor peptides and prostate cancer risk: a systematic review and metaanalysis. Int J Cancer 124(10):2416–2429
Tan W, Huang M et al (2011) Anti-cancer natural products isolated from Chinese medicinal herbs. Chin Med 6(1):1–15
Rafieian-Kopaie M, Nasri H (2015) On the occasion of world cancer day 2015: the possibility of cancer prevention or treatment with antioxidants: the ongoing cancer prevention researches. Int J Prev Med 6:108–112. https://doi.org/10.4103/2008-7802.169077
Lachenmayer A, Alsinet C, Chang CY, Liovit JM (2010) Molecular approaches to treatment of hepatocellular carcinoma. Dig Liver Dis 42:264–272
Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod 70:461–477
Sakarkar DM, Deshmukh VN (2011) Ethnopharmacological review of traditional medicinal plants for anticancer activity. Int J PharmTech Res 3:298–308
Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C et al (2015) Discovery and resupply of pharmacologically active plant-derived natural products: a review. Biotechnol Adv 33(8):1582–1614
Dias DA, Urban S, Roessner U (2012) A historical overview of natural products in drug discovery. Meta 2:303–336
Cragg GM, Newman DJ (1830) Natural products: a continuing source of novel drug leads. Biochim Biophys Acta 2013:3670–3695
Jeong SJ, Koh W, Kim B, Kim SH (2011) Are there new therapeutic options for treating lung cancer based on herbal medicines and their metabolites? J Ethnopharmacol 138:652–661
Richardson MA, White JD (2000) Complementary/alternative medicine and cancer research. A national initiative. Cancer Pract 8:45–48
Gerber B, Scholz C, Reimer T, Briese V, Janni W (2006) Complementary and alternative therapeutic approaches in patients with early breast cancer: a systematic review. Breast Cancer Res Treat 95:199–209
Sedlacek HH (2001) Mechanisms of action of flavopiridol. Crit Rev Oncol Hematol 38:139–170
Kapoor S (2013) Combretastatin A4 and its emerging antineoplastic effects. Surgery 153:881
Shu-Yi Y, Wen-Chi W, Feng-Yin J, Ning-Sun Y (2013) Therapeutic applications of herbal medicines for cancer patients. Evid Based Complement Alternat Med 302426:1–15
Sanjar A, Deepti K, Richa G, Amita V, Ashu M (2013) Role of herbals in cancer management. J Phytopharmacol 2(6):46–51
Ngoc HN, Qui THT, Quang TP et al (2020) Anticancer activity of novel plant extracts and compounds from Adenosma bracteosum (Bonati) in human lung and liver cancer cells. Molecules 25:2912–2928
Kyo E, Uda N, Suzuki A, Kakimoto M, Ushijima M, Kasuga S, Itakura Y (1998) Immunomodulation and antitumor activities of aged garlic extract. Phytomedicine 5:259–267
Kyo E, Uda N, Kasuga S, Itakura Y, Sumiyoshi H (1999) In: Wagner H (ed) Garlic as an immuno -stimulant, immuno-modulatory agents from plants. Birkhauser Verlag, Basel, pp 273–288
Niwat K, Houghton PJ, Eno-Amooquaye E, Burke PJ (1997) Activity of extracts and alkaloids of Thai Aistonia species against human lung cancer cell lines. Planta Med 63:97–101
Wu TH, Yeh KY, Wang CH et al (2019) The combination of Astragalus membranaceus and Angelica sinensis inhibits lung cancer and cachexia through its immunomodulatory function. J Oncol 3–4:1–15
Curic S, Tadic Z, Valpotic I, Sulimanovic D, Basic I (1992) The effect of bee venom on tumor growth and metastasis formation of mammary carcinoma in CBA mice. Vet Arh 62:S31–S35
Akindele AJ, Wani Z, Mahajan G, Sharma S, Aigbe FR, Sati N (2015) Anticancer activity of Aristolochia ringens Vahl. (Aristolochiaceae). J Tradit Complement Med 5(1):35–41
Cassileth BR, Rizvi N, Deng G et al (2009) Safety and pharmacokinetic trial of docetaxel plus an Astragalus-based herbal formula for non-small cell lung cancer patients. Cancer Chemother Pharmacol 65:67–71
Manglani N, Vaishnava S, Dhamodaran P, Sawarkar H (2014) In-vitro and in-vivo anti-cancer activity of leaf extract of B. grandiflora. Int J Pharm Sci 6(3):70–82
Juthathip P, Patompong K, Subhawat S et al (2020) Potential of Thai herbal extracts on lung cancer treatment by inducing apoptosis and synergizing chemotherapy. Molecules 25:231–260
Wu S (1991) Preoperative intravenous drip of an anti-tumor Chinese herb preparation Brucea javanica oil emulsion (Ya Dan Zi Emulsion) for lung cancer. Shang-Hai I Hsueh 14:273–275
Hu B, Yang N, Liu W, Sha H, Yu D (1991) Estimation of integrations of various functional groups of Brucea javanica (L.) Merr. Oil. Bopuxue Zazhi 8:433–440
Su S et al (1985) Treatment of lung cancer with brain metastasis by using intravenous drip of 10% emulsion of Brucea javanica seminal oil. Chin J Integ Trad West Med 5:86–88
Loder J, Russell G (1969) Tumor inhibitory plants. The alkaloids of Bruguiera sexangula and Bruguiera exaristata (Rhizophoraceae). Aust J Chem 22:1271
Bochuan Y, Rui Y, Youngsheng M, Shan Z, Xiaodong Z, Ying L (2017) A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications. Pharm Biol 55(1):620–635
Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN, Ray C (1968) Screening of Indian plants for biological activity: part I. Indian J Exp Biol 6:232–247
Wu F, Zhou L, Jin W, Yang W, Wang Y, Yan B et al (2016) Antiproliferative and apoptosis-inducing effect of theabrownin against non-small cell lung adenocarcinoma A549 cells. Front Pharmacol 7:465
Jiang Y, Chen J, Wu Z, Lin L, Feng S (1998) Inhibitory effect of tea polyphenol on mice lung cancer induced by diethyl stilbestrol combined with urethane. Weisheng Dulixue Zazhi 12:7–9
Snodgrass MJ, Burke JD, Meetz GD (1976) Inhibitory effect of shark serum on the Lewis lung carcinoma. J Natl Cancer Inst 56:981–983
Kimura Y, Baba K, Okuda H (2000) Inhibitory effects of active substances isolated from Cassia garrettiana heartwood on tumor growth and lung metastasis in Lewis lung carcinoma-bearing mice (part 1). Anticancer Res 20:2899–2906
Nazir T, Taha N, Islam A, Abraham S, Mahmood A, Mustafa M (2016) Monocytopenia; induction by vinorelbine, cisplatin and doxorubicin in breast, non-small cell lung and cervix cancer patients. Int J Health Sci 10(4):542–547
Gaidhani SN, Singh A, Kumari S, Lavekar GS, Juekar AS, Sen S (2013) Evaluation of some plant extracts for standardization and anticancer activity. Indian J Tradit Knowl 12(4):682–687
Alothman EA, Awaad AS, Al-Qurayn NA, Al-Kanhal HF, El-Meligy RM, Zain YM (2018) Anticancer effect of Cenchrus ciliaris L. Saudi Pharm J 26(7):952–955
Staniszewski A, Slesak B, Kolodziej J, Harlozinska-Szmyrka A, Nowicky J (1992) Lymphocyte subsets in patients with lung cancer treated with thiophosphoric acid alkaloid derivatives from Chelidonium majus L. (Ukrain). Drugs Exp Clin Res 18:63–67
Noda K, Ohno N, Tanaka K, Okuda M, Yadomae T, Nomoto K, Shoyama Y (1998) A new type of biological response modifier from Chlorella vulgaris which needs protein moiety to show an antitumour activity. Phytother Res 12:309–319
Kupchan SM, Kopperman HL (1975) L-usnic acid: tumor inhibitor isolated from lichens. Experientia 31:625–752
Aranya M, Mathukorn S, Chariny C, Worapaka M, Jiradej M (2016) In vitro anti-cancer activities of Job’s tears (Coix lachryma-jobi Linn.) extracts on human colon adenocarcinoma. Saudi J Biol Sci 23:248–256
Bhavna J et al (2016) Cytotoxic and pro-apoptotic activities of leaf extract of Croton bonplandianus Baill. Against lung cancer cell line A549. Indian J Exp Biol 54:379–385
Kupchan SM, Hemingway RJ, Coggon P, Mc Phail AT, Sim GA (1968) Crotepoxide, a novel cyclohexane diepoxide tumor inhibitor from Croton macrostachys. J Am Chem Soc 90:2982
Kupchan SM, Hemingway RJ, Smith RM (1969) Tumor inhibitors. XLV. Crotepoxide, a novel cyclohexane diepoxide tumor inhibitor from Croton macrostachys. J Org Chem 34:3898–3902
Hiren JM, Vipul P, Ruxana T (2014) Curcumin and lung cancer- a review. Targ Oncol 9(4):295–310. https://doi.org/10.1007/s11523-014-0321-1
Djioev FK (1965) Influence of extract of eleutherococcus on arising of urethane induced lung adenomas in mice. Vopr Onkol 11:51
Kupchan SM, Uchida I, Branfman AR, Dailey RG, Fei BY (1976) Antileukemic principles isolated from Euphorbiaceae plants. Science 191:571–572
Shentu J, Wei P, Wang A et al (1984) A study of the antitumor effect of Euphorbia fischeriana steud on mice with induced tumor. Chin J Integ Trad West Med 4:46–47
Seied MV, Mehrdad I, Amirhossein S (2013) Cytotoxic activities of phytochemicals from ferula species. DARU J Pharm Sci 21(39):1–7
Furusawa E, Chou S, Furusawa S, Hirazumi A, Dang Y (1992) Antitumor activity of Ganoderma lucidum, an edible mushroom, on intraperitoneally implanted Lewis lung carcinoma in syngeneic mice. Phytother Res 6:300–304
Kimura Y, Taniguchi M, Baba K (2002) Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance. Anticancer Res 22:3309–3318
Zhang YY, Huang CT, Liu SM, Wang B, Guo J, Bai JQ et al (2016) Licochalcone A exerts antitumor activity in bladder cancer cell lines and mice models. Trop J Pharm Res 15(6):1151–1157
Jung SK, Lee MH, Kim JE, Singh P, Lee SY, Jeong CH et al (2014) Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR. J Biol Chem 289:35839–35848
Yong YL, Tan LT, Ming LC, Chan KG, Lee LH, Goh BH et al (2017) The effectiveness and safety of topical capsaicin in postherpetic neuralgia: a systematic review and meta-analysis. Front Pharm 7:538
Saitoh H, Feng W, Matsuzawa T, Ikekawa T (1997) Antitumor activity of Hypsizigus marmoreus. II. Preventive effect against lung metastasis of Lewis lung carcinoma. Yakugaku Zasshi 117:1006–1010
Shokrzadeh M, Parvaresh A, Shahani S, Habibi E, Zalzar Z (2013) Cytotoxic effects of Lagenaria siceraria Standl. Extract on cancer cell line. J Mazandaran Univ Med Sci 23:225–230
Nanba H, Mori K, Toyomasu T, Kuroda H (1987) Antitumor action of shiitake (Lentinus edodes) fruit bodies orally administered to mice. Chem Pharm Bull 35:2453–2458
Tripathy G, Pradhan D, Pradhan S, Dasmohapatra T (2016) Evaluation of plant extracts against lung cancer using H460 cell line. Asian J Pharm Clin Res 9(2):227–229
Medini F, Bourgou S, Lalancette KG et al (2015) Phytochemical analysis, anti-oxidant, anti-inflammatory and anticancer activities of the halophyte Limonium densiflorum extracts on human cell lines and murine macrophages. S Afr J Bot 99:158–164
Tanawan K (2005) Molecular mechanism of herbs in human lung cancer cells. J Med Assoc Thail 88(11):1725–1734
Kupchan SM, Komoda Y, Court WA, Thomas GJ, Smith RM, Karim A, Gilmore CJ, Haltiwanger RC, Bryan RF (1972) Tumor inhibitors. LXXIII. Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus. J Am Chem Soc 94:1354–1356
Hirazumi A, Furusawa E, Chou S, Hokama Y (1996) Immunomodulation contributes to the anticancer activity of Morinda citrifolia (noni) fruit juice. Proc West Pharmacol Soc 39:7–9
Shaban A, Mani GM, Nautiyal R (2012) In vitro cytotoxicity of Moringa oleifera against different human cancer cell lines. Asian J Pharm Clin Res 5:271–272
Anchala IK, Priyani P, Charitha LG (2019) Medicinal plants commonly used against cancer in traditional medicine formulae in Sri Lanka. Saudi Pharm J 27:565–573
Md. Asaduzzaman K, Han-chun C, Mousumi T, Dian-zheng Z (2011) Anticancer activities of Nigella sativa (Black cumin). Afr J Tradit Complement Altern Med 8(S):226–232
Wozniak L, Skapska S, Marszalek K (2015) Ursolic acid-a pentacyclic triterpenoid with a wide spectrum of pharmacological activities. Molecule 20:20614–20641
Yun YS, Lee YS, Jo SK, Jung IS (1993) Inhibition of autochthonous tumor by ethanol insoluble fraction from Panax ginseng as an immunomodulator. Planta Med 59:521–524
Yun TK, Yun YS, Han IW (1980) An experimental study on tumor inhibitory effect of red ginseng in mice and rats exposed to various chemical carcinogens. In: Proc. 3rd Int. Ginseng Symp. Seoul, South Korea. pp 87–113
Yang C, Lu W, Niu J (1983) Studies on the antitumor action of xiangshenboheyou (a mixture composed of Pelargonium graveolens and Sophora flavescens and other herbs). Chung Ts'ao Yao 14:409–410
Han S, Lee C, Jeon Y, Hong N, Yoo I, Yang K, Kim H (1999) The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis. Immunopharmacology 41:157–164
Ngamkitidechakul C, Jaijo K, Hansakul P, Soonthornchareonnon N, Sireeratawong S (2010) Antitumour effects of phyllanthus emblica l.: induction of cancer cell apoptosis and inhibition of in vivo tumour promotion and in vitro invasion of human cancer cells. Phytother Res 24:1405–1413
Choi JY, Hong WG, Cho JH, Kim EM, Kim J, Jung CH et al (2015) Podophyllotoxin acetate triggers anticancer effects against nonsmall cell lung cancer cells by promoting cell death via cell cycle arrest, ER stress and autophagy. Int J Oncol 47:1257–1265
Chin-Chuan C, Chun-Pin K, Mei-Miao C, Shu-Huei W (2017) The anti-cancer effects and mechanisms of Scutellaria barbata D. Don on CL1-5 lung cancer cells. Oncotarget 8(65):109340–109357
Sebastian Y, Hamm-Ming S, Chih-Hung L (2017) Solanum incanum extract (SR-T100) induces melanoma cell apoptosis and inhibits established lung metastasis. Oncotarget 8(61):103509–103517
Al Sinani SS, Eltayeb EA, Coomber BL, Adham SA (2016) Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway. Cancer Cell Int 16(1):11
Sorbera L, Castaner R, Leeson P (2000) Ae-941 oncolytic antipsoriatic treatment of age related macular degeneration angiogenesis inhibitor. Drugs Future 25:551–557
Ickes GR, Fong HHS, Schiff PL, Perdue JRE, Farnsworth NR (1973) Antitumor activity and preliminary phytochemical examination of Tagetes minuta (Compositae). J Pharm Sci 62:1009–1011
Robinson JP, Suriya K, Subbaiya R, Ponmurugan P (2017) Antioxidant and cytotoxic activity of Tecoma stans against lung cancer cell line (A549). Braz J Pharm Sci 53(3):1–5
Qi C et al (2002) Apoptosis of a human non-small cell lung cancer (NSCLC) cell line, PLA-801, induced by acutiaporberine, a novel bisalkaloid derived from Thalictrum acutifolium (Hand.-Mazz.) Boivin. Biochem Pharmacol 63(8):1389–1396
Sabzali S, Arman R, Panahi J, Havasian MR, Haghani K, Bakhtiyari S (2014) Investigation on the inhibitory effects of hydroalcoholic extract of Thymbra spicata on the growth of lung cancer cell line SK-Mes-1. J Ilam Univ Med Sci 22:153–158
Furusawa E, Furusawa S (1989) Anticancer potential of viva-natural, a dietary seaweed extract, on Lewis lung carcinoma in comparison with chemical immunomodulators and on cyclosporine accelerated akr leukemia. Oncology 46:343–349
Khwaja T, Dias C, Pentecost S (1986) Recent studies on the anticancer activities of mistletoe (Viscum album) and its alkaloids. Oncology 43(Suppl):42–50
Mishra L, Singh B, Dagenais S (2000) Scientific basis for the treatment use of Withania somnifera (Ashwagandha). Altern Med Rev 5:334–346
Singh S, Singh D, Gupta M, Singh N, Kohli R (1979) An experimental evaluation of antitumor activity of Withania somnifera (Ashwagandha) and Geriforte. Indian J Pharmacol 11:65b
Vedamurthy AB, Shettar AK, Madagi SB (2018) Phytochemical screening and in-vitro antioxidant and Antiproliferative activity of aqueous leaf extract of Ximenia americana against non- small cell lung Cancer. Cancer Surg (Los Angel, CA) 3(1):117–124
Sokoloff B (1968) The oncostatic and oncolytic factors present in certain plants. Oncology 22:49
Jaradat NA, Al-Ramahi R, Zaid AN, Ayesh OI, Eid AM (2016) Ethnopharmacological survey of herbal remedies used for treatment of various types of cancer and their methods of preparations in the West Bank-Palestine. BMC Complement Altern Med 16(93):1–12
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Awati, S.S. et al. (2021). Effect of Medicinal Plants against Lung Cancer. In: Dua, K., Nammi, S., Chang, D., Chellappan, D.K., Gupta, G., Collet, T. (eds) Medicinal Plants for Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-33-6850-7_12
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