Skip to main content

Effect of Medicinal Plants against Lung Cancer

  • Chapter
  • First Online:
Medicinal Plants for Lung Diseases

Abstract

Lung cancer is a chronic disease and speaks to one of the greatest health care issues for mankind. It is an illness with a high morbidity and high demise rates. Subsequently, it is regularly connected with a plenty of affliction and general abatement in the quality of life. Just chemotherapy and radiation therapies are now and again effective and in much occasions harmful and deadly. Alternative and less toxic medicine is very considerably essential to this ailment. The goal of this study is to review the medicinal plants having antitumor activity for the management of lung cancer. Medicinal plants are presently standing out as likely wellsprings of anticancer specialists and are broadly utilized because of accessibility of the materials, generally modest, little, or no side effects, wide pertinence, and helpful adequacy which thus have quickened the scientific exploration. The study was directed with lung cancer cell line (Human), on humans and animals, and lung carcinoma (Lewis) was the maximum utilized exploratory model. In this review we have summarized some medicinal plants keep being an abundant wellspring of herbal remedies or bioactive composites against Lung cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. American Cancer Society (2010) Cancer facts & figures. American Cancer Society, Atlanta

    Google Scholar 

  2. Luo J, Solimini NL, Elledge SJ (2009) Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 136:823–837

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674

    Article  CAS  PubMed  Google Scholar 

  4. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70

    Article  CAS  PubMed  Google Scholar 

  5. Kashfi K (2013) Dysfunctional cell signaling dynamics in oncology: diagnostic, prognostic and treatment opportunities. Biochem Pharmacol 85:595–596

    Article  CAS  PubMed  Google Scholar 

  6. Alwan A, Maclean DR, Riley LM, d'Espaignet ET, Mathers CD, Stevens GA, Bettcher D (2010) Monitoring and surveillance of chronic non-communicable diseases: progress and capacity in high-burden countries. Lancet 376:1861–1868

    Article  PubMed  Google Scholar 

  7. CDC—Global Cancer Statistics. http://www.cdc.gov/cancer/international/statistics.htm. Accessed 21 Jan 2016

  8. Ford DW, Koch KA, Ray DE, Selecky PA (2013) Palliative and end-of-life care in lung cancer. Chest 143(5 Suppl):498S–512S

    Article  Google Scholar 

  9. GBD 2015 Risk Factors Collaborators (2016) Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the global burden of disease study 2015. Lancet 388(10053):1659–1724

    Article  Google Scholar 

  10. Alberg AJ, Brock MV, Ford JG, Samet JM, Spivack SD (2013) Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 143:1–29

    Article  Google Scholar 

  11. Rom WN, Hay JG, Lee TC, Jiang Y (2000) Molecular and genetic aspects of lung cancer. Am J Respir Crit Care Med 16:1355–1367

    Article  Google Scholar 

  12. Duarte RLM, Paschoal MEM (2005) Marcadores moleculares no câncer de pulmão: papel prognóstico e sua relação com o tabagismo. J Braz Pneumol 32:56–65

    Article  Google Scholar 

  13. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ, Thun MJ (2005) Cancer statistics, 2005. Cancer J Clin 55:10–30

    Article  Google Scholar 

  14. Robert JC (2002) Lung cancer: a review. Am J Health-Syst Pharm 59(1):611–642

    Google Scholar 

  15. Rowlands MA, Gunnell D, Harris R, Vatten LJ, Holly JMP, Martin RM (2009) Circulating insulin-like growth factor peptides and prostate cancer risk: a systematic review and metaanalysis. Int J Cancer 124(10):2416–2429

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Tan W, Huang M et al (2011) Anti-cancer natural products isolated from Chinese medicinal herbs. Chin Med 6(1):1–15

    Article  CAS  Google Scholar 

  17. Rafieian-Kopaie M, Nasri H (2015) On the occasion of world cancer day 2015: the possibility of cancer prevention or treatment with antioxidants: the ongoing cancer prevention researches. Int J Prev Med 6:108–112. https://doi.org/10.4103/2008-7802.169077

    Article  PubMed  PubMed Central  Google Scholar 

  18. Lachenmayer A, Alsinet C, Chang CY, Liovit JM (2010) Molecular approaches to treatment of hepatocellular carcinoma. Dig Liver Dis 42:264–272

    Article  CAS  Google Scholar 

  19. Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod 70:461–477

    Article  CAS  PubMed  Google Scholar 

  20. Sakarkar DM, Deshmukh VN (2011) Ethnopharmacological review of traditional medicinal plants for anticancer activity. Int J PharmTech Res 3:298–308

    Google Scholar 

  21. Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C et al (2015) Discovery and resupply of pharmacologically active plant-derived natural products: a review. Biotechnol Adv 33(8):1582–1614

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Dias DA, Urban S, Roessner U (2012) A historical overview of natural products in drug discovery. Meta 2:303–336

    CAS  Google Scholar 

  23. Cragg GM, Newman DJ (1830) Natural products: a continuing source of novel drug leads. Biochim Biophys Acta 2013:3670–3695

    Google Scholar 

  24. Jeong SJ, Koh W, Kim B, Kim SH (2011) Are there new therapeutic options for treating lung cancer based on herbal medicines and their metabolites? J Ethnopharmacol 138:652–661

    Article  CAS  PubMed  Google Scholar 

  25. Richardson MA, White JD (2000) Complementary/alternative medicine and cancer research. A national initiative. Cancer Pract 8:45–48

    Article  CAS  PubMed  Google Scholar 

  26. Gerber B, Scholz C, Reimer T, Briese V, Janni W (2006) Complementary and alternative therapeutic approaches in patients with early breast cancer: a systematic review. Breast Cancer Res Treat 95:199–209

    Article  CAS  PubMed  Google Scholar 

  27. Sedlacek HH (2001) Mechanisms of action of flavopiridol. Crit Rev Oncol Hematol 38:139–170

    Article  CAS  PubMed  Google Scholar 

  28. Kapoor S (2013) Combretastatin A4 and its emerging antineoplastic effects. Surgery 153:881

    Article  PubMed  Google Scholar 

  29. Shu-Yi Y, Wen-Chi W, Feng-Yin J, Ning-Sun Y (2013) Therapeutic applications of herbal medicines for cancer patients. Evid Based Complement Alternat Med 302426:1–15

    Google Scholar 

  30. Sanjar A, Deepti K, Richa G, Amita V, Ashu M (2013) Role of herbals in cancer management. J Phytopharmacol 2(6):46–51

    Article  Google Scholar 

  31. Ngoc HN, Qui THT, Quang TP et al (2020) Anticancer activity of novel plant extracts and compounds from Adenosma bracteosum (Bonati) in human lung and liver cancer cells. Molecules 25:2912–2928

    Article  CAS  Google Scholar 

  32. Kyo E, Uda N, Suzuki A, Kakimoto M, Ushijima M, Kasuga S, Itakura Y (1998) Immunomodulation and antitumor activities of aged garlic extract. Phytomedicine 5:259–267

    Article  CAS  PubMed  Google Scholar 

  33. Kyo E, Uda N, Kasuga S, Itakura Y, Sumiyoshi H (1999) In: Wagner H (ed) Garlic as an immuno -stimulant, immuno-modulatory agents from plants. Birkhauser Verlag, Basel, pp 273–288

    Chapter  Google Scholar 

  34. Niwat K, Houghton PJ, Eno-Amooquaye E, Burke PJ (1997) Activity of extracts and alkaloids of Thai Aistonia species against human lung cancer cell lines. Planta Med 63:97–101

    Article  Google Scholar 

  35. Wu TH, Yeh KY, Wang CH et al (2019) The combination of Astragalus membranaceus and Angelica sinensis inhibits lung cancer and cachexia through its immunomodulatory function. J Oncol 3–4:1–15

    Google Scholar 

  36. Curic S, Tadic Z, Valpotic I, Sulimanovic D, Basic I (1992) The effect of bee venom on tumor growth and metastasis formation of mammary carcinoma in CBA mice. Vet Arh 62:S31–S35

    CAS  Google Scholar 

  37. Akindele AJ, Wani Z, Mahajan G, Sharma S, Aigbe FR, Sati N (2015) Anticancer activity of Aristolochia ringens Vahl. (Aristolochiaceae). J Tradit Complement Med 5(1):35–41

    Article  PubMed  Google Scholar 

  38. Cassileth BR, Rizvi N, Deng G et al (2009) Safety and pharmacokinetic trial of docetaxel plus an Astragalus-based herbal formula for non-small cell lung cancer patients. Cancer Chemother Pharmacol 65:67–71

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Manglani N, Vaishnava S, Dhamodaran P, Sawarkar H (2014) In-vitro and in-vivo anti-cancer activity of leaf extract of B. grandiflora. Int J Pharm Sci 6(3):70–82

    Google Scholar 

  40. Juthathip P, Patompong K, Subhawat S et al (2020) Potential of Thai herbal extracts on lung cancer treatment by inducing apoptosis and synergizing chemotherapy. Molecules 25:231–260

    Article  CAS  Google Scholar 

  41. Wu S (1991) Preoperative intravenous drip of an anti-tumor Chinese herb preparation Brucea javanica oil emulsion (Ya Dan Zi Emulsion) for lung cancer. Shang-Hai I Hsueh 14:273–275

    Google Scholar 

  42. Hu B, Yang N, Liu W, Sha H, Yu D (1991) Estimation of integrations of various functional groups of Brucea javanica (L.) Merr. Oil. Bopuxue Zazhi 8:433–440

    CAS  Google Scholar 

  43. Su S et al (1985) Treatment of lung cancer with brain metastasis by using intravenous drip of 10% emulsion of Brucea javanica seminal oil. Chin J Integ Trad West Med 5:86–88

    CAS  Google Scholar 

  44. Loder J, Russell G (1969) Tumor inhibitory plants. The alkaloids of Bruguiera sexangula and Bruguiera exaristata (Rhizophoraceae). Aust J Chem 22:1271

    Article  CAS  Google Scholar 

  45. Bochuan Y, Rui Y, Youngsheng M, Shan Z, Xiaodong Z, Ying L (2017) A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications. Pharm Biol 55(1):620–635

    Article  CAS  Google Scholar 

  46. Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN, Ray C (1968) Screening of Indian plants for biological activity: part I. Indian J Exp Biol 6:232–247

    CAS  PubMed  Google Scholar 

  47. Wu F, Zhou L, Jin W, Yang W, Wang Y, Yan B et al (2016) Antiproliferative and apoptosis-inducing effect of theabrownin against non-small cell lung adenocarcinoma A549 cells. Front Pharmacol 7:465

    Article  PubMed  PubMed Central  Google Scholar 

  48. Jiang Y, Chen J, Wu Z, Lin L, Feng S (1998) Inhibitory effect of tea polyphenol on mice lung cancer induced by diethyl stilbestrol combined with urethane. Weisheng Dulixue Zazhi 12:7–9

    CAS  Google Scholar 

  49. Snodgrass MJ, Burke JD, Meetz GD (1976) Inhibitory effect of shark serum on the Lewis lung carcinoma. J Natl Cancer Inst 56:981–983

    Article  CAS  PubMed  Google Scholar 

  50. Kimura Y, Baba K, Okuda H (2000) Inhibitory effects of active substances isolated from Cassia garrettiana heartwood on tumor growth and lung metastasis in Lewis lung carcinoma-bearing mice (part 1). Anticancer Res 20:2899–2906

    CAS  PubMed  Google Scholar 

  51. Nazir T, Taha N, Islam A, Abraham S, Mahmood A, Mustafa M (2016) Monocytopenia; induction by vinorelbine, cisplatin and doxorubicin in breast, non-small cell lung and cervix cancer patients. Int J Health Sci 10(4):542–547

    Google Scholar 

  52. Gaidhani SN, Singh A, Kumari S, Lavekar GS, Juekar AS, Sen S (2013) Evaluation of some plant extracts for standardization and anticancer activity. Indian J Tradit Knowl 12(4):682–687

    Google Scholar 

  53. Alothman EA, Awaad AS, Al-Qurayn NA, Al-Kanhal HF, El-Meligy RM, Zain YM (2018) Anticancer effect of Cenchrus ciliaris L. Saudi Pharm J 26(7):952–955

    Article  PubMed  PubMed Central  Google Scholar 

  54. Staniszewski A, Slesak B, Kolodziej J, Harlozinska-Szmyrka A, Nowicky J (1992) Lymphocyte subsets in patients with lung cancer treated with thiophosphoric acid alkaloid derivatives from Chelidonium majus L. (Ukrain). Drugs Exp Clin Res 18:63–67

    PubMed  Google Scholar 

  55. Noda K, Ohno N, Tanaka K, Okuda M, Yadomae T, Nomoto K, Shoyama Y (1998) A new type of biological response modifier from Chlorella vulgaris which needs protein moiety to show an antitumour activity. Phytother Res 12:309–319

    Article  CAS  Google Scholar 

  56. Kupchan SM, Kopperman HL (1975) L-usnic acid: tumor inhibitor isolated from lichens. Experientia 31:625–752

    Article  CAS  PubMed  Google Scholar 

  57. Aranya M, Mathukorn S, Chariny C, Worapaka M, Jiradej M (2016) In vitro anti-cancer activities of Job’s tears (Coix lachryma-jobi Linn.) extracts on human colon adenocarcinoma. Saudi J Biol Sci 23:248–256

    Article  Google Scholar 

  58. Bhavna J et al (2016) Cytotoxic and pro-apoptotic activities of leaf extract of Croton bonplandianus Baill. Against lung cancer cell line A549. Indian J Exp Biol 54:379–385

    Google Scholar 

  59. Kupchan SM, Hemingway RJ, Coggon P, Mc Phail AT, Sim GA (1968) Crotepoxide, a novel cyclohexane diepoxide tumor inhibitor from Croton macrostachys. J Am Chem Soc 90:2982

    Article  CAS  PubMed  Google Scholar 

  60. Kupchan SM, Hemingway RJ, Smith RM (1969) Tumor inhibitors. XLV. Crotepoxide, a novel cyclohexane diepoxide tumor inhibitor from Croton macrostachys. J Org Chem 34:3898–3902

    Article  CAS  PubMed  Google Scholar 

  61. Hiren JM, Vipul P, Ruxana T (2014) Curcumin and lung cancer- a review. Targ Oncol 9(4):295–310. https://doi.org/10.1007/s11523-014-0321-1

    Article  Google Scholar 

  62. Djioev FK (1965) Influence of extract of eleutherococcus on arising of urethane induced lung adenomas in mice. Vopr Onkol 11:51

    Google Scholar 

  63. Kupchan SM, Uchida I, Branfman AR, Dailey RG, Fei BY (1976) Antileukemic principles isolated from Euphorbiaceae plants. Science 191:571–572

    Article  CAS  PubMed  Google Scholar 

  64. Shentu J, Wei P, Wang A et al (1984) A study of the antitumor effect of Euphorbia fischeriana steud on mice with induced tumor. Chin J Integ Trad West Med 4:46–47

    Google Scholar 

  65. Seied MV, Mehrdad I, Amirhossein S (2013) Cytotoxic activities of phytochemicals from ferula species. DARU J Pharm Sci 21(39):1–7

    Google Scholar 

  66. Furusawa E, Chou S, Furusawa S, Hirazumi A, Dang Y (1992) Antitumor activity of Ganoderma lucidum, an edible mushroom, on intraperitoneally implanted Lewis lung carcinoma in syngeneic mice. Phytother Res 6:300–304

    Article  Google Scholar 

  67. Kimura Y, Taniguchi M, Baba K (2002) Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance. Anticancer Res 22:3309–3318

    CAS  PubMed  Google Scholar 

  68. Zhang YY, Huang CT, Liu SM, Wang B, Guo J, Bai JQ et al (2016) Licochalcone A exerts antitumor activity in bladder cancer cell lines and mice models. Trop J Pharm Res 15(6):1151–1157

    Article  CAS  Google Scholar 

  69. Jung SK, Lee MH, Kim JE, Singh P, Lee SY, Jeong CH et al (2014) Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR. J Biol Chem 289:35839–35848

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Yong YL, Tan LT, Ming LC, Chan KG, Lee LH, Goh BH et al (2017) The effectiveness and safety of topical capsaicin in postherpetic neuralgia: a systematic review and meta-analysis. Front Pharm 7:538

    Article  CAS  Google Scholar 

  71. Saitoh H, Feng W, Matsuzawa T, Ikekawa T (1997) Antitumor activity of Hypsizigus marmoreus. II. Preventive effect against lung metastasis of Lewis lung carcinoma. Yakugaku Zasshi 117:1006–1010

    Article  CAS  PubMed  Google Scholar 

  72. Shokrzadeh M, Parvaresh A, Shahani S, Habibi E, Zalzar Z (2013) Cytotoxic effects of Lagenaria siceraria Standl. Extract on cancer cell line. J Mazandaran Univ Med Sci 23:225–230

    Google Scholar 

  73. Nanba H, Mori K, Toyomasu T, Kuroda H (1987) Antitumor action of shiitake (Lentinus edodes) fruit bodies orally administered to mice. Chem Pharm Bull 35:2453–2458

    Article  CAS  Google Scholar 

  74. Tripathy G, Pradhan D, Pradhan S, Dasmohapatra T (2016) Evaluation of plant extracts against lung cancer using H460 cell line. Asian J Pharm Clin Res 9(2):227–229

    CAS  Google Scholar 

  75. Medini F, Bourgou S, Lalancette KG et al (2015) Phytochemical analysis, anti-oxidant, anti-inflammatory and anticancer activities of the halophyte Limonium densiflorum extracts on human cell lines and murine macrophages. S Afr J Bot 99:158–164

    Article  CAS  Google Scholar 

  76. Tanawan K (2005) Molecular mechanism of herbs in human lung cancer cells. J Med Assoc Thail 88(11):1725–1734

    Google Scholar 

  77. Kupchan SM, Komoda Y, Court WA, Thomas GJ, Smith RM, Karim A, Gilmore CJ, Haltiwanger RC, Bryan RF (1972) Tumor inhibitors. LXXIII. Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus. J Am Chem Soc 94:1354–1356

    Article  CAS  PubMed  Google Scholar 

  78. Hirazumi A, Furusawa E, Chou S, Hokama Y (1996) Immunomodulation contributes to the anticancer activity of Morinda citrifolia (noni) fruit juice. Proc West Pharmacol Soc 39:7–9

    CAS  PubMed  Google Scholar 

  79. Shaban A, Mani GM, Nautiyal R (2012) In vitro cytotoxicity of Moringa oleifera against different human cancer cell lines. Asian J Pharm Clin Res 5:271–272

    Google Scholar 

  80. Anchala IK, Priyani P, Charitha LG (2019) Medicinal plants commonly used against cancer in traditional medicine formulae in Sri Lanka. Saudi Pharm J 27:565–573

    Article  Google Scholar 

  81. Md. Asaduzzaman K, Han-chun C, Mousumi T, Dian-zheng Z (2011) Anticancer activities of Nigella sativa (Black cumin). Afr J Tradit Complement Altern Med 8(S):226–232

    Google Scholar 

  82. Wozniak L, Skapska S, Marszalek K (2015) Ursolic acid-a pentacyclic triterpenoid with a wide spectrum of pharmacological activities. Molecule 20:20614–20641

    Article  CAS  Google Scholar 

  83. Yun YS, Lee YS, Jo SK, Jung IS (1993) Inhibition of autochthonous tumor by ethanol insoluble fraction from Panax ginseng as an immunomodulator. Planta Med 59:521–524

    Article  CAS  PubMed  Google Scholar 

  84. Yun TK, Yun YS, Han IW (1980) An experimental study on tumor inhibitory effect of red ginseng in mice and rats exposed to various chemical carcinogens. In: Proc. 3rd Int. Ginseng Symp. Seoul, South Korea. pp 87–113

    Google Scholar 

  85. Yang C, Lu W, Niu J (1983) Studies on the antitumor action of xiangshenboheyou (a mixture composed of Pelargonium graveolens and Sophora flavescens and other herbs). Chung Ts'ao Yao 14:409–410

    Google Scholar 

  86. Han S, Lee C, Jeon Y, Hong N, Yoo I, Yang K, Kim H (1999) The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis. Immunopharmacology 41:157–164

    Article  CAS  PubMed  Google Scholar 

  87. Ngamkitidechakul C, Jaijo K, Hansakul P, Soonthornchareonnon N, Sireeratawong S (2010) Antitumour effects of phyllanthus emblica l.: induction of cancer cell apoptosis and inhibition of in vivo tumour promotion and in vitro invasion of human cancer cells. Phytother Res 24:1405–1413

    Article  CAS  PubMed  Google Scholar 

  88. Choi JY, Hong WG, Cho JH, Kim EM, Kim J, Jung CH et al (2015) Podophyllotoxin acetate triggers anticancer effects against nonsmall cell lung cancer cells by promoting cell death via cell cycle arrest, ER stress and autophagy. Int J Oncol 47:1257–1265

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Chin-Chuan C, Chun-Pin K, Mei-Miao C, Shu-Huei W (2017) The anti-cancer effects and mechanisms of Scutellaria barbata D. Don on CL1-5 lung cancer cells. Oncotarget 8(65):109340–109357

    Article  Google Scholar 

  90. Sebastian Y, Hamm-Ming S, Chih-Hung L (2017) Solanum incanum extract (SR-T100) induces melanoma cell apoptosis and inhibits established lung metastasis. Oncotarget 8(61):103509–103517

    Article  Google Scholar 

  91. Al Sinani SS, Eltayeb EA, Coomber BL, Adham SA (2016) Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway. Cancer Cell Int 16(1):11

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  92. Sorbera L, Castaner R, Leeson P (2000) Ae-941 oncolytic antipsoriatic treatment of age related macular degeneration angiogenesis inhibitor. Drugs Future 25:551–557

    Article  CAS  Google Scholar 

  93. Ickes GR, Fong HHS, Schiff PL, Perdue JRE, Farnsworth NR (1973) Antitumor activity and preliminary phytochemical examination of Tagetes minuta (Compositae). J Pharm Sci 62:1009–1011

    Article  CAS  PubMed  Google Scholar 

  94. Robinson JP, Suriya K, Subbaiya R, Ponmurugan P (2017) Antioxidant and cytotoxic activity of Tecoma stans against lung cancer cell line (A549). Braz J Pharm Sci 53(3):1–5

    Article  CAS  Google Scholar 

  95. Qi C et al (2002) Apoptosis of a human non-small cell lung cancer (NSCLC) cell line, PLA-801, induced by acutiaporberine, a novel bisalkaloid derived from Thalictrum acutifolium (Hand.-Mazz.) Boivin. Biochem Pharmacol 63(8):1389–1396

    Article  Google Scholar 

  96. Sabzali S, Arman R, Panahi J, Havasian MR, Haghani K, Bakhtiyari S (2014) Investigation on the inhibitory effects of hydroalcoholic extract of Thymbra spicata on the growth of lung cancer cell line SK-Mes-1. J Ilam Univ Med Sci 22:153–158

    Google Scholar 

  97. Furusawa E, Furusawa S (1989) Anticancer potential of viva-natural, a dietary seaweed extract, on Lewis lung carcinoma in comparison with chemical immunomodulators and on cyclosporine accelerated akr leukemia. Oncology 46:343–349

    Article  CAS  PubMed  Google Scholar 

  98. Khwaja T, Dias C, Pentecost S (1986) Recent studies on the anticancer activities of mistletoe (Viscum album) and its alkaloids. Oncology 43(Suppl):42–50

    Article  CAS  PubMed  Google Scholar 

  99. Mishra L, Singh B, Dagenais S (2000) Scientific basis for the treatment use of Withania somnifera (Ashwagandha). Altern Med Rev 5:334–346

    CAS  PubMed  Google Scholar 

  100. Singh S, Singh D, Gupta M, Singh N, Kohli R (1979) An experimental evaluation of antitumor activity of Withania somnifera (Ashwagandha) and Geriforte. Indian J Pharmacol 11:65b

    Google Scholar 

  101. Vedamurthy AB, Shettar AK, Madagi SB (2018) Phytochemical screening and in-vitro antioxidant and Antiproliferative activity of aqueous leaf extract of Ximenia americana against non- small cell lung Cancer. Cancer Surg (Los Angel, CA) 3(1):117–124

    Google Scholar 

  102. Sokoloff B (1968) The oncostatic and oncolytic factors present in certain plants. Oncology 22:49

    Article  CAS  PubMed  Google Scholar 

  103. Jaradat NA, Al-Ramahi R, Zaid AN, Ayesh OI, Eid AM (2016) Ethnopharmacological survey of herbal remedies used for treatment of various types of cancer and their methods of preparations in the West Bank-Palestine. BMC Complement Altern Med 16(93):1–12

    Google Scholar 

Download references

Conflict of Interest

The authors declare no conflict of interest.

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Awati, S.S. et al. (2021). Effect of Medicinal Plants against Lung Cancer. In: Dua, K., Nammi, S., Chang, D., Chellappan, D.K., Gupta, G., Collet, T. (eds) Medicinal Plants for Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-33-6850-7_12

Download citation

Publish with us

Policies and ethics