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Plant-Based Chemical Moieties for Targeting Chronic Respiratory Diseases

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Targeting Cellular Signalling Pathways in Lung Diseases

Abstract

The World Health Organization (WHO) has reported that chronic respiratory diseases such as asthma, chronic obstructive pulmonary disease, interstitial lung disease, and lung cancer are among the major chronic human diseases that posed a huge challenge to public health and socioeconomic growth. Pharmacotherapy is crucial in the management of these diseases; however, the utilization of conventional treatments is found to be futile, as most patients remained poorly controlled with low quality of life. This has prompted the discovery and development of novel therapeutic agents to improve treatment outcomes. Over the years, researchers have studied a vast range of natural products for their potential in managing chronic respiratory diseases. It has been demonstrated that chemical moieties obtained from plant sources improved pharmacokinetic and toxicological profiles, with a robust multi-prolonged action. Hence, they are held in high regard as possible replacements to address the limitations faced by current therapies. In this chapter, such a phytochemical approach with respect to their molecular mechanisms targeting signalling pathways involved in various chronic respiratory diseases will be discussed. We have also summarized some of the experimental evidence that supports the use of plant-based chemical moieties in chronic respiratory diseases.

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Authors and Affiliations

  1. School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia

    Yinghan Chan & Sin Wi Ng

  2. Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

    Yinghan Chan

  3. Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia

    Sin Wi Ng

  4. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia

    Kamal Dua

  5. Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia

    Dinesh Kumar Chellappan

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  1. Yinghan Chan
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Editors and Affiliations

  1. Graduate School of Health, Discipline of Pharmacy, University of Technology Sydney, Sydney, NSW, Australia

    Kamal Dua

  2. Drug Development and Innovation Centre, University of Alberta, Edmonton, AB, Canada

    Raimar Löbenberg

  3. Haematology and Hemotherapy Center, State University of Campinas, Campinas, São Paulo, Brazil

    Ângela Cristina Malheiros Luzo

  4. Graduate School of Health, Discipline of Pharmacy, University of Technology Sydney, Sydney, NSW, Australia

    Shakti Shukla

  5. School of Pharmaceutical Sciences & Division of Research & Development, Lovely Professional University, Phagwara, Punjab, India

    Saurabh Satija

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Chan, Y., Ng, S.W., Dua, K., Chellappan, D.K. (2021). Plant-Based Chemical Moieties for Targeting Chronic Respiratory Diseases. In: Dua, K., Löbenberg, R., Malheiros Luzo, Â.C., Shukla, S., Satija, S. (eds) Targeting Cellular Signalling Pathways in Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-33-6827-9_34

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