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Targeting Host and Bacterial Signaling Pathways in Tuberculosis: An Effective Strategy for the Development of Novel Anti-tubercular Therapies

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Targeting Cellular Signalling Pathways in Lung Diseases

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Abstract

Tuberculosis (TB) is a pandemic disease caused by an obligate intracellular pathogen Mycobacterium tuberculosis (M.tb). The current TB therapy, Directly Observed Treatment Short-Course (DOTS), consists of the prolonged use of four antibiotics (Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol) that must be administered alone or in combination for at least 6 months to patients affected by drug-sensitive pulmonary TB. Although this therapy is efficient in eliminating M.tb, it has numerous side effects such as liver toxicity, poor compliance, and development of multidrug-resistant strains. Therefore, there is an urgent need for the development of new drug targets for the effective management of the disease and to also ensure the prevention of reinfection and reactivation of the disease. Here, in this chapter, we have discussed the presently available drugs and their mechanism of action for the treatment of TB as well as various other drugs, which have been repurposed and deployed for the treatment against drug-sensitive and drug-resistant TB.

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Authors and Affiliations

  1. Immunobiology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India

    Samreen Fatima, Bhavya Bhardwaj & Ved Prakash Dwivedi

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  1. Samreen Fatima
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  2. Bhavya Bhardwaj
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  3. Ved Prakash Dwivedi
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Correspondence to Ved Prakash Dwivedi .

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Editors and Affiliations

  1. Graduate School of Health, Discipline of Pharmacy, University of Technology Sydney, Sydney, NSW, Australia

    Kamal Dua

  2. Drug Development and Innovation Centre, University of Alberta, Edmonton, AB, Canada

    Raimar Löbenberg

  3. Haematology and Hemotherapy Center, State University of Campinas, Campinas, São Paulo, Brazil

    Ângela Cristina Malheiros Luzo

  4. Graduate School of Health, Discipline of Pharmacy, University of Technology Sydney, Sydney, NSW, Australia

    Shakti Shukla

  5. School of Pharmaceutical Sciences & Division of Research & Development, Lovely Professional University, Phagwara, Punjab, India

    Saurabh Satija

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Fatima, S., Bhardwaj, B., Dwivedi, V.P. (2021). Targeting Host and Bacterial Signaling Pathways in Tuberculosis: An Effective Strategy for the Development of Novel Anti-tubercular Therapies. In: Dua, K., Löbenberg, R., Malheiros Luzo, Â.C., Shukla, S., Satija, S. (eds) Targeting Cellular Signalling Pathways in Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-33-6827-9_16

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