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Thyroid Cancer and SNPs

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Genetic Polymorphism and cancer susceptibility

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Abstract

Thyroid cancer (TC) is the most common endocrine malignancy especially in women with papillary thyroid carcinoma (PTC) being the most prevalent type of endocrine cancer whose incidence is growing. Despite the favorable outcome and long survival rates of most patients, some tumors display an aggressive behavior and may progress to the highly aggressive and lethal, anaplastic thyroid carcinoma. In recent years, several progresses have been made on the molecular characterization of TC. The large number of single nucleotide polymorphism (SNP) markers available in the public databases makes studies of association and fine mapping of disease loci very practical. In this chapter we have summarized the genetic characterization of TC, giving a particular emphasis to SNPs, their diagnostic importance in the risk stratification of TC and their therapeutic value.

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Abbreviations

AFIP:

Armed Forces Institute of Pathology

AJCC:

The American Joint Committee on Cancer

ATC:

Anaplastic TC

BTD:

Benign thyroid disease

DNA:

Deoxyribonucleic acid

DTC:

Differentiated thyroid carcinoma

ERCC2:

Excision repair cross-complementation group 2

FTC:

Follicular TC

HCC:

Hürthle cell cancer

HRAS:

Harvey rat sarcoma

HSCR:

Hirschsprung disease

MALT:

Mucosa-associated lymphoid tissue

MTC:

Medullary TC

OS:

Oxidative stress

PDTC:

Poorly differentiated thyroid carcinoma

PTC:

Papillary TC

RET:

Rearranged during transfection

RNA:

Ribonucleic acid

TC:

Thyroid cancer

TP53:

Tumor protein 53

TSH:

Thyroid-stimulating hormone

TSHR:

Thyroid-stimulating hormone receptor

XPD:

Xeroderma pigmentosum group D

XRCC1:

X-ray repair cross-complementing protein 1

XRCC3:

X-ray repair cross-complementing protein 3

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Authors and Affiliations

  1. Department of Biochemistry, Government Medical College Srinagar & Associated Hospitals, Srinagar, Jammu and Kashmir, India

    Mosin S. Khan

  2. Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Kashmir, India

    Mosin S. Khan & Syed Mudassar

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  1. Mosin S. Khan
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  2. Syed Mudassar
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Editors and Affiliations

  1. Basic Medical Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Jeddah, Saudi Arabia

    Aga Syed Sameer

  2. Department of Biochemistry, Government Medical College, Karan Nagar, Srinagar, Jammu and Kashmir, India

    Mujeeb Zafar Banday

  3. Department of Biochemistry, Government Medical College, Karan Nagar, Srinagar, Jammu and Kashmir, India

    Saniya Nissar

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Khan, M.S., Mudassar, S. (2021). Thyroid Cancer and SNPs. In: Sameer, A.S., Banday, M.Z., Nissar, S. (eds) Genetic Polymorphism and cancer susceptibility. Springer, Singapore. https://doi.org/10.1007/978-981-33-6699-2_8

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