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Probiotic Based Interventions for Improving Intestinal Health

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Probiotic Research in Therapeutics

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Abstract

Probiotics are beneficial microbial strains used for improving intestinal health, through the modulation of the microbiota of the gut. These microbes play a critical role in regulating nutrition, metabolism, physiology, and immunity of human. Gut microbes are unique in nature and are non-pathogenic with anti-inflammatory potential and are responsible for maintenance of resistance in the intestine. This paper provides a broad review on promising intestinal probiotic properties of Lactobacillus sp., Bifidobacterium sp., and other yeast species, and their role in the prevention of acute gastroenteritis, inflammatory bowel disease, atopic dermatitis, allergic asthma, food allergy, food-induced anaphylaxis, Candida infection, colic infection, enter colitis, H. pylori infection, celiac disease, ulcerative colitis along with the importance of probiotic-rich foods for gut health.

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Abbreviations

CD:

Celiac disease

DOB:

Delta over baseline

EFFCA:

European food and feed cultures association

EFSA:

European food safety authority

GI:

Gastrointestinal

IBD:

Inflammatory bowel disease

IKB:

I Kappa B protein

LAB:

Lactic acid bacteria

MALT:

Mucosa-associated lymphoid tissue lymphoma

NF-kB:

Nuclear factor kappa B

QPS:

Qualified presumption of safety

SCFAs:

Short chain fatty acids

UC:

Ulcerative colitis

References

  • Aagaard K, Riehle K, Ma J, Segata N, Mistretta TA, Coarfa C, Raza S, Rosenbaum S, Van den Veyver I, Milosavljevic A, Gevers D, Huttenhower C, Petrosino J, Versalovic J (2012) A Metagenomic approach to characterization of the vaginal microbiome signature in pregnancy. PLoS ONE 7(6):1–15

    Article  Google Scholar 

  • Adriano Gomes DC, Flávia C, Alonso B, Cinthia Hoch Batista DS, José Assis FF, Susana MIS (2009) Probiotic cheese: health benefits, technological and stability aspects. Trends Food Sci Technol 20:344–354

    Article  Google Scholar 

  • Akito KK, Kensei N, Mai T, Mitsuhisa K, Hiroko KH, Kazunori S, Hiroshi I, Yusuke G, Kensuke S, Takahiro M, Akira K, Ryoutaro H, Osamu W, Tomoki I, Kouji M, Yuki K, Kazuhito R (2016) Fermented milk containing lactobacillus casei strain shirota preserves the diversity of the gut microbiota and relieves abdominal dysfunction in healthy medical students exposed to academic stress. Appl Environ Microbiol 82(12):3649–3658

    Article  Google Scholar 

  • Aloysius W, Davey Yueh SN, Lydia AD, Amanda O, Renee Lay HL (2015) Detection of antibiotic resistance in probiotics of dietary supplements. Nutr J 14:95–101

    Article  Google Scholar 

  • Amir Q, Aboudola S, Warny M, Michetti P, Pothoulakis C, LaMont JT, Kelly CP (2001) Saccharomyces boulardii stimulates intestinal immunoglobulin A immune response to Clostridium difficile toxin a in mice. Infect Immun 69(4):2762–2765

    Article  Google Scholar 

  • Anabrees J, Indrio F, Paes B, Alfaleh K (2013) Probiotics for infantile colic: a systematic review. BMC Pediatr 13(186):1–9

    Google Scholar 

  • Astrup A (2014) Yogurt and dairy product consumption to prevent cardiometabolic diseases: epidemiologic and experimental studies. Am J Clin Nutr 99:1235–1242

    Article  Google Scholar 

  • Baohong W, Mingfei Y, Longxian L, Zongxin L, Lanjuan L (2017) The human microbiota in health and disease. Engineering 3:71–82

    Article  Google Scholar 

  • Bean K, Varga Z, Petrov VO, Boyko N, Rajnavolgyi E (2017) Gut microbiota species can provoke both inflammatory and tolerogenic immune responses in human dendritic cells mediated by retinoic acid receptor alpha ligation. Front Immunol 8(427):1–17

    Google Scholar 

  • Binna K, Hong VM, Yang J, Hyun H, Im JJ, Hwang J, Yoon S, Kim JE (2016) A review of fermented foods with beneficial effects on brain and cognitive function. Prev Nutr Food Sci 21(4):297–309

    Article  Google Scholar 

  • Bourdichon F, Casaregola S, Farrokh C, Frisvad JC, Gerds ML, Hammes WP, Harnett J, Huys G, Laulund S, Ouwehand A, Powell IB, Prajapati JB, Seto Y, TerSchure E, Van Boven A, Vankerckhoven V, Zgoda A, Tuijtelaars S, Hansen EB (2012) Food fermentations: microorganisms with technological beneficial use. Int J Food Microbiol 154:87–97

    Article  CAS  PubMed  Google Scholar 

  • Breidt F, Mc Feeters RF, Perez DI, Lee CH (2013) Fermented vegetables. Food microbiology: fundamentals and frontiers, 4th edn. ASM Press, Washington, DC. https://doi.org/10.1128/9781555818463.ch33

  • Brenner DM, Chey WD (2009) Bifidobacterium infantis 35624: a novel probiotic for the treatment of irritable bowel syndrome. Rev Gastroenterol Disord 9(1):7–15

    PubMed  Google Scholar 

  • Catherine S, Whitney JC, Lord SR, Herbert RD, Cumming RG (2008) Effective exercise for the prevention of falls: a systematic review and meta-analysis. J Am Geriatr Soc 56(12):22–34

    Google Scholar 

  • Cekin AH, Sahinturk Y, Akbay Harmandar F, Uyar S, Oguz Yolcular B, Cekin Y (2017) Use of probiotics as an adjuvant to sequential H. pylori eradication therapy: impact on eradication rates, treatment resistance, treatment-related side effects, and patient compliance. Turkish J Gastroenterol 28(1):3–11

    Article  Google Scholar 

  • Cevikbas A, Yemni E, Ezzedenn FW, Yardimici T, Cevikbas U, Stohs SJ (1994) Antitumoural, antibacterial and antifungal activities of Kefir and Kefir grain. Phytother Res 8:78–82

    Article  Google Scholar 

  • Chang H, Kim K, Nam Y, Roh S, Kim M, Jeon C, Oh H, Bae J (2008) Analysis of yeast and archaeal population dynamics in kimchi using denaturing gradient gel electrophoresis. Int J Food Microbiol. 126(1–2):159–116

    Article  CAS  PubMed  Google Scholar 

  • Charalabos P, Kelly CP, Joshi MA, Gao N, O’keane CJ, Castagliuolo I, Lamont JT (1993) Saccharomyces boulardii Inhibits Clostridium difficile Toxin A binding and enterotoxicity in Rat Ileum. Gastroenterology 104:1108–1115

    Article  Google Scholar 

  • Chau K, Lau E, Greenberg S (2015) Probiotics for infantile colic: a randomized, double-blind, placebo controlled trial investigating Lactobacillus reuteri DSM 17938. J Pediatr 166(1):74–78

    Article  CAS  PubMed  Google Scholar 

  • Chen J, Cai W, Feng Y (2007) Development of intestinal bifidobacteria and Lactobacilli in breastfed neonates. Clin Nutr 26:559–566

    Google Scholar 

  • Chen Z, Shi J, Yang X, Nan B, Liu Y, Wang Z (2015) Chemical and physical characteristics and antioxidant activities of the exopolysaccharide produced by Tibetan kefir grains during milk fermentation. Int Dairy J 43:15–21

    Article  Google Scholar 

  • Chyn BW, Odamaki T, Xiao J-Z (2019) Beneficial effects of Bifidobacteriumlongumsubsp.longumBB536 on human health: modulation of gut microbiome as the principal action. J Functional Foods 54:506–519

    Article  Google Scholar 

  • Cho J, Lee D, Yang C, Jeon J, Kim J, Han H (2006) Microbial population dynamics of kimchi, a fermented cabbage product. FEMS Microbiol Lett 257(2):262–267

    Article  CAS  PubMed  Google Scholar 

  • Christoph B, Longford N, Gale C, Modi N, Uthaya S (2018) Body composition following necrotising enterocolitis in preterm infants. Neonatology 113:242–248

    Article  Google Scholar 

  • Christoph H, Julia P, Juliane S, Janne PH, Michael Z, Dorothee V, Christian G, Stephan G, David F, Jan R, Egbert H, Wolfgang G (2017) Lactobacillus acidophilus/Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics. Sci Rep 7:5633–5643

    Article  Google Scholar 

  • D’arienzo R, Stefanile R, Maurano F, Mazzarella G, Ricca E, Troncone R, Auricchio S, Rossi M (2011) Immunomodulatory effects of Lactobacillus casei administration in a mouse model of gliadin-sensitive enteropathy. Scandinavian J Immunol 74:335–341

    Article  Google Scholar 

  • Denis DGM, Laurent B, Olivier F, Maria JF, Agnés M, Jean LB, Gerard C (2005) Streptococcus thermophilus and Lactobacillus delbrueckii subsp. Bulgaricus survive gastrointestinal transit of healthy volunteers consuming yogurt. FEMS Microbiol Lett 250(2):185–187

    Article  Google Scholar 

  • Dufresne C, Farnworth E (2000) Tea, Kombucha, and health: a review. Food Res Int 33:409–421

    Article  CAS  Google Scholar 

  • Dylag K, Hubalewska MM, Surmiak M, Szmyd J, Brzozowski T (2014) Probiotics in the mechanism of protection against gut inflammation and therapy of gastrointestinal disorders. Curr Pharm Des 20(7):1149–1155

    Article  CAS  PubMed  Google Scholar 

  • Elsa J, Florian C, Harry S, Philippe L, Luis G, Bermúdez H (2017) Probiotic strain Lactobacillus casei BL23 prevents colitis associated colorectal cancer. Front Immunol 8:1–10

    Google Scholar 

  • Fang F, Jie X, Qiaoyu L, Xiaoxuan X, Guocheng D (2018) Characterization of a Lactobacillus brevis strain with potential oral probiotic properties. BMCMicrobiol 18(221):1–9

    Google Scholar 

  • Franqois C, Ducrotte P, Lerebours E, Colin R, Humbert G, Denis P (1991) Effects of Amoxicillin-Clavulanate combination on the motility of the small intestine in human beings. Antimicrobial Agents Chemother 35(6):1085–1088

    Article  Google Scholar 

  • Fridman WH, Zitvogel L, Sautes-Fridman C, Kroemer G (2017) The immune contexture in cancer prognosis and treatment. Nat. Rev. Clin. Oncol. 14:717–734

    Article  CAS  PubMed  Google Scholar 

  • Galdeano CM, Perdigón G (2007) The probiotic bacterium Lactobacillus casei induces activation of the gut mucosal immune system through innate immunity. Clin Vaccine Immunol 13:219–226

    Article  Google Scholar 

  • Gayathri D, Rashmi BS (2016) Anti-cancer properties of probiotics: a natural strategy for cancer prevention. EC Nutr 5:1191–1202

    Google Scholar 

  • Gijsbers L, Ding EL, Malik VS, de Goede GJ, Geleijnse JM, Soedamah MSS (2016) Consumption of dairy foods and diabetes incidence: a dose-response meta-analysis of observational studies. Am J Clin Nutr 103(4):1111–1124

    Article  CAS  PubMed  Google Scholar 

  • Gilliland SE, Speck ML (1977) Antagonistic action of Lactobacillus acidophilus towards intestinal and foodborne pathogens in associative cultures. J Food Protect 40(12):820–823

    Article  CAS  Google Scholar 

  • Gómez M, Barizzone F, Brozzi R, Correia S, Heng L, Istace F, Lythgo C, Fernandéz EPS (2017) Scientific opinion on the update of the list of QPS recommended biological agents intentionally added to food or feed as notified to EFSA. EFSA J 15:1–178

    Google Scholar 

  • Greco L, Gobbetti M, Auricchio R, Di Mase R, Landolfo F, Paparo F, Di Cagno R, De Angelis M, Rizzello CG, Cassone A (2011) Safety for patients with celiac disease of baked goods made of wheat flour hydrolysed during food processing. Clin Gastroenterol Hepatol 9:24–29

    Article  PubMed  Google Scholar 

  • Guslandi M, Mezzi G, Sorghi M, Testoni PA (2000) Saccharomyces boulardii in maintenance treatment of Crohn’s disease. Dig Dis Sci 45(7):1462–1464

    Article  CAS  PubMed  Google Scholar 

  • Guslandi M, Giollo P, Testoni PA (2003) A pilot trial of Saccharomyces boulardii in ulcerative colitis. Eur J Gastroenterol Hepatol 15:697–698

    Article  PubMed  Google Scholar 

  • Guzel SZB, Kok TT, Greene AK, Seydim AC (2011) Review: functional properties of kefir. Crit Rev Food Sci Nutr 51(3):261–268

    Article  Google Scholar 

  • Hara M, Hanaoka T, Kobayashi M, Otani T, Adachi HY, Montani A, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Matsuzawa T, Ikekawa T, Sasaki S, Sugane S (2003) Cruciferous vegetables, mushrooms, and gastrointestinal cancer risks in a multicenter, hospital-based case-control study in Japan. Nutr Cancer 46:13–47

    Article  Google Scholar 

  • Hatakka K, Holma R, El Nezami H, Suomalainen T, Kuisma M, Saxelin M, Poussa T, Mykkänen H, Korpela R (2008) The influence of Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp. shermanii JS on potentially carcinogenic bacterial activity in human colon. Int J Food Microbiol 128:406–410

    Article  CAS  PubMed  Google Scholar 

  • Hennequin C, Kauffmann Lacroix C, Jobert A, Viard JP, Ricour C, Jacquemin JL, Berche P (2000) Possible role of catheters in Saccharomyces boulardii fungemia. Eur J Clin Microbiol Infect Dis 19:16–20

    Article  CAS  PubMed  Google Scholar 

  • Hong Y, Yang HS, Chang HC, Kim HY (2013) Comparison of bacterial community changes in fermenting Kimchi at two different temperatures using a denaturing gradient gel electrophoresis analysis. J Microbiol Biotechnol 23(1):76–84

    Article  CAS  PubMed  Google Scholar 

  • Ibarra A, Latreille BM, Donazzolo Y, Pelletier X, Ouwehand AC (2018) Effects of 28- day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: a double-blind, randomized, placebo-controlled, and dose-ranging trial. Gut Microbes 9(3):236–251

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Imase K, Tanaka A, Tokunaga K, Sugano H, Ishida H, Takahashi S (2007) Lactobacillus reuteri tablets suppress Helicobacter pylori infection–a double-blind randomised placebo controlled cross-over clinical study. J Japanese Assoc Infect Dis 81(4):387–393

    Google Scholar 

  • Inoue R, Otsuka M, Nishio A, Ushida K (2007) Primary administration of Lactobacillus johnsonii NCC533 in weaning period suppresses the elevation of proinflammatory cytokines and CD86 gene expressions in skin lesions in NC/Nga mice. FEMS Immunol Med Microbiol 50:67–76

    Article  CAS  PubMed  Google Scholar 

  • Ishikawa H (2003) Randomized controlled trial of the effect of bifidobacteria-fermented milk on ulcerative colitis. J Am Coll Nutr 22:56–63

    Article  PubMed  Google Scholar 

  • Jamie M, Pinto MD, Petrova A (2015) Lactobacillus acidophilus mixture in treatment of children hospitalized with acute diarrhea. Clin Pediatr 55(13):1202–1209

    Google Scholar 

  • Jung SL, Gun YH, Jun WL, Yun JO, Jeong AP, Yong HP, Yu RP, Jong SA (2004) Analysis of Kimchi microflora using denaturing gradient gel electrophoresis. Int J Food Microbiol 102(2):143–150

    Google Scholar 

  • Kaburagi T, Yamano T, Fukushima Y, Yoshino H, Mito N (2007) Effect of Lactobacillus johnsonii La1 on immune function and serum albumin in aged and malnourished aged mice. Nutrition 23:342–350

    Article  CAS  PubMed  Google Scholar 

  • Kafshdooz T, Akbarzadeh A, Majdi Seghinsara A, Pourhassan M, Nasrabadi HT, Milani M (2017) Role of probiotics in managing of Helicobacter pylori infection: a review. Drug Res 67(2):88–93

    CAS  Google Scholar 

  • Kang BK, Cho MS, Park DS (2016) Red pepper powder is a crucial factor that influences the ontogeny of Weissella cibaria during kimchi fermentation. Sci Rep 6:1–8

    Google Scholar 

  • Kaukinen K, Lindfors K, Mäki M (2014) Advances in the treatment of coeliac disease: an immunopathogenic perspective. Nat Rev Gastroenterol Hepatol 11:36–44

    Article  CAS  PubMed  Google Scholar 

  • Kennedy AR (1995) The evidence for soybean products as cancer preventive agents. J Nutr 125:733–743

    Google Scholar 

  • Koji I, Miyata K, Mohri M, Hideki O, Hideo Y (2017) The effects of the habitual consumption of miso soup on the blood pressure and heart rate of Japanese adults: a cross-sectional study of a health examination. Int Med 56:23–29

    Article  Google Scholar 

  • Kruis W (2004) Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut 53:1617–1623

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kuipers EJ (1997) Helicobacter pylori and the risk and management of associated diseases: gastritis, ulcer disease, atrophic gastritis and gastric cancer. Aliment Pharmacol Ther 11(1):71–88

    Article  PubMed  Google Scholar 

  • Lira-Junior R, Boström EA (2018) Oral-gut connection: One step closer to an integrated view of the gastrointestinal tract? Mucosal Immunol 11:316–318

    Article  CAS  PubMed  Google Scholar 

  • Liu HY, Roos S, Jonsson H, Ah D, Dicksved J, Lindberg JE, Lundh T (2015) Effects of Lactobacillus johnsonii and Lactobacillus reuteri on gut barrier function and heat shock proteins in intestinal porcine epithelial cells. Physiol Rep 3(4):1–13

    Article  Google Scholar 

  • Liu K (2000) Expanding soybean food utilization. Food Technol 54:46–58

    Google Scholar 

  • Liu Z, Qin H, Yang Z, Xia Y, Liu W, Yang J, Jiang Y, Zhang H, Yang Z, Wang Y (2011) Randomised clinical trial: the effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery: a double-blind study. Aliment Pharmacol Ther 33:50–63

    Article  CAS  PubMed  Google Scholar 

  • Lorenzo C, Laura M, Veronica S, Francesco L, Francesco A (2014) T helper cells plasticity in inflammation. CytometryA 85(1):36–42

    Article  Google Scholar 

  • Madsen KL (2012) Enhancement of epithelial barrier function by probiotics. J Epithelial Biol Pharmacol 5:55–59

    Article  CAS  Google Scholar 

  • Makarova K, Slesarev A, Wolf Y, Sorokin A, Mirkin B, Koonin E, Pavlov A, Pavlova N, Karamychev V, Polouchine N (2006) Comparative genomics of the lactic acid bacteria. Proc Natl Acad Sci U S A 103(42):15611–15616

    Article  PubMed  PubMed Central  Google Scholar 

  • Markowiak P, Śliżewska K (2017) Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients 9(9):1–30

    Google Scholar 

  • Messina M (1995) Modern applications for an ancient bean: soybeans and the prevention and treatment of chronic disease. J Nutr 125:567–569

    Google Scholar 

  • Moraes LFS, Grzeskowiak LM, Teixeira TFS, Peluzio MCG (2014) Intestinal microbiota and probiotics in celiac disease. Clin Microbiol Rev 27:482–489

    Article  Google Scholar 

  • Najma HJ, Musaad BA, Jagdish K (2016) Oral feeding of probiotic Bifidobacterium infantis: colonic morphological changes in rat model of TNBS-induced colitis. Scientifica 1–11

    Google Scholar 

  • Nardis C, Mastromarino P, Mosca L (2013) Vaginal microbiota and viral sexually transmitted diseases. Annali di Igiene 25(5):443–456

    CAS  PubMed  Google Scholar 

  • Neu J, Walker WA (2011) Necrotizing enterocolitis. N Engl J Med 364(255–264):1–12

    Google Scholar 

  • Nóvoa Medina Y, López-Capapé M, Lara Orejas E, Alonso Blanco M, Camarero Salces C, Barrio Castellanos R (2008) Impact of diagnosis of celiac disease on metabolic control of Type 1 diabetes. An Pediatr (Barc) 68(1):13–17

    Article  Google Scholar 

  • Oelschlaeger AT (2009) Mechanisms of probiotic actions - a review. Int J Med Microbiol 300(1):57–62

    Article  PubMed  Google Scholar 

  • Ohara T, Yoshino K, Kitajima M (2010) Possibility of preventing colorectal carcinogenesis with probiotics. Hepato Gastroenterol 57:1411–1415

    Google Scholar 

  • Oskar A, Simin NM, Robert MR (2004) Yogurt and gut function. Am J Clin Nutr 80:245–256

    Article  Google Scholar 

  • Ourtin P, Rul FO (2003) Interactions between microorganisms in a simple ecosystem: yogurt bacteria as a study model. Le Lait 84:125–134

    Google Scholar 

  • Pavlova SI, Kilic AO, Kilic SS (2002) Genetic diversity of vaginal lactobacilli from women in different countries based on 16S rRNA gene sequences. J Appl Microbiol 92(3):451–459

    Article  CAS  PubMed  Google Scholar 

  • Peñas E, Martinez VC, Frias J (2017) Sauerkraut: production, composition, and health benefits. Fermented Foods in Health and Disease Prevention 557–576

    Google Scholar 

  • Perdigon G, Alvarez S, Rachid M, Agüero G, Gobbato N (1995) Immune system stimulation by probiotics. J Dairy Sci 78:1597–1606

    Article  CAS  PubMed  Google Scholar 

  • Reid G (2012) Microbiology: categorize probiotics to speed research. Nature 23(7399):446

    Article  Google Scholar 

  • Ricci A, Allende A, Bolton D, Chemaly M, Davies R, Girones R, Herman L, Koutsoumanis K, Lindqvist R, Nørrung B, Robertson L, Ru G, Sanaa M, Simmons M, Skandamis P, Snary E, Speybroeck N, Ter Kuile B, Threlfall J, Wahlström H, Cocconcelli PS, Klein G, Prieto Maradona M, Querol A, Peixe L, Suarez JE, Sundh I, Vlak JM, Aguilera G.M, Barizzone F, Brozzi R, Correia S, Heng L, Istace F, Lythgo C, Fernandéz EPS (2017) Scientific opinion on the update of the list of QPS- recommended biological agents intentionally added to food or feed as notified to EFSA. EFSA J 15:4664

    Google Scholar 

  • Rijkers GT, De V, Brummer WM, Morelli RJ, Corthier L, Marteau GP (2011) Health benefits and health claims of probiotics: bridging science and marketing. Br J Nutr 106:1291–1296

    Article  CAS  PubMed  Google Scholar 

  • Rima H, Steve L, Ismail F (2012) Antimicrobial and probiotic properties of yeasts: from fundamental to novel applications. Front Microbiol 3:1–12

    Google Scholar 

  • Rodrigues KL, Caputo LRG, Carvalho JCT, Evangelista J, Schneedorf JM (2005a) Antimicrobial and healing activity of kefir and Kefiran extract. Int J Antimicrob Agents 25:404–408

    Article  CAS  PubMed  Google Scholar 

  • Rodrigues KL, Carvalho JCT, Schneedorf JM (2005b) Anti-inflammatory properties of Kefir and its polysaccharide extract. Inflammopharmacology:13485–13492

    Google Scholar 

  • Roma H, Steve L, Ismail F (2012) Antimicrobial and probiotic properties of yeasts: from fundamental to novel applications. Front Microbiol 3:1–12

    Google Scholar 

  • Salas Jara MJ, Sanhueza EA, Retamal Díaz A, González C, Urrutia H, García A (2016) Probiotic Lactobacillus fermentum UCO-979C biofilm formation on AGS and Caco-2 cells and Helicobacter pylori inhibition. Biofouling 32(10):1245–1257

    Article  CAS  PubMed  Google Scholar 

  • Saloheimo P (2005) Captain cook used sauerkraut to prevent scurvy. Duodecim 121:1014–1015

    PubMed  Google Scholar 

  • Sartor RB (2004) Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics. Gastroenterology 126:1620–1633

    Article  PubMed  Google Scholar 

  • Savino F, Cordisco L, Tarasco V (2010) Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trial. Pediatrics 126(3):526–533

    Article  Google Scholar 

  • Savino F, Quartieri A, De Marco A (2016) Comparison of formula fed infants with and without colic revealed significant differences in total bacteria, Enterobacteriaceae and faecal ammonia. Acta Paediatr 4:573–578

    Google Scholar 

  • Schreck Bird A, Gregory PJ, Jalloh MA, Risoldi Cochrane Z, Hein DJ (2017) Probiotics for the treatment of infantile colic: a systematic review. J Pharm Pract 30(3):366–374

    Article  PubMed  Google Scholar 

  • Seockmo K, Park MS, Ji GE, You HJ (2016) Review on Bifidobacterium bifidum BGN4: functionality and nutraceutical applications as a probiotic microorganism. Int J Mol Sci 17(9):1–23

    Google Scholar 

  • Serafini F, Turroni P, Ruas Madiedo GA, Lugli C, Milani S, Duranti N (2014) Kefir fermented milk and kefiran promote growth of Bifidobacterium bifidum PRL2010 and modulate its gene expression. Int J Food Microbiol 178:50–59

    Article  CAS  PubMed  Google Scholar 

  • Sharma G, Im SH (2018) Probiotics as a potential immunomodulating pharmabiotics in allergic diseases: current Status and Future Prospects. Allergy Asthma Immunol Res 10(6):575–590

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shiou R, Yu Y, Guo Y, He SM, Andrew CHM, Hoenig J, Sun J, Petrof EO, Claud EC (2013) Synergistic protection of combined probiotic conditioned media against neonatal necrotizing enterocolitis like intestinal injury. PLoS ONE 8(5):65–108

    Article  Google Scholar 

  • Stetinova V, Smetanova L, Kvetina J, Svoboda Z, Zidek Z, Tlaskalova Hogenova H (2010) Caco-2 cell monolayer integrity and effect of pro-biotic Escherichia coli Nissle 1917 components. Neuro Endocrinol Lett 31(Suppl 2):51–56

    CAS  PubMed  Google Scholar 

  • Sung V, Collett S, De Gooyer T, Hiscock H, Tang M, Wake M (2013) Probiotics to prevent or treat excessive infant crying: systematic review and meta-analysis. JAMA Pediatr 167(12):1150–1157

    Article  PubMed  Google Scholar 

  • Sung V, Cabana MD, D’Amico F (2014) Lactobacillus reuteri DSM 17938 for managing infant colic: protocol for an individual participant data meta analysis. BMJ Open 4(12):64–75

    Article  Google Scholar 

  • Szajewska H, Gyrczuk E, Horvath A (2013) Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, double-blind, placebo-controlled trial. J Pediatr 162(2):257–262

    Article  PubMed  Google Scholar 

  • Taverniti V, Scabiosi C, Arioli S, Mora D, Gugliel Metti S (2013) Short-term daily intake of 6 billion live probiotic cells can be insufficient in healthy adults to modulate the intestinal bifidobacteria and Lactobacilli. J Funct Foods 6:482–491

    Article  Google Scholar 

  • Teemu T, Pienihäkkinen K, Isolauri E, Söderling E (2011) Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in infancy. Br J Nutr 105:409–416

    Article  Google Scholar 

  • Teoh AL, Heard G, Cox J (2004) Yeast ecology of kombucha fermentation. Int J Food Microbiol 95(2):119–126

    Article  CAS  PubMed  Google Scholar 

  • Thygesen JB, Glerup H, Tarp B (2012) Saccharomyces boulardii fungemia caused by treatment with a probioticum. BMJ Case Rep 1–3

    Google Scholar 

  • Tomaro DC, Jones ML, Shah D, Jain P, Saha S, Prakash S (2014). Cholesterol assimilation by Lactobacillus probiotic bacteria: an in vitro investigation. Bio Med Res Int 1–9

    Google Scholar 

  • Tomita M, Maeda M (2015) Mechanisms and biological importance of photon-induced bystander responses: do they have an impact on low-dose radiation responses. J Radiat Res 56(2):205–219

    Article  CAS  PubMed  Google Scholar 

  • Venturi A (1999) Impact on the composition of the faecal flora by a new probiotic preparation: preliminary data on maintenance treatment of patients with ulcerative colitis. Aliment Pharmacol Ther 13:1103–1108

    Article  CAS  PubMed  Google Scholar 

  • Vinderola G, Perdigón G, Duarte J, Farnworth E, Matar C (2006) Effects of the oral administration of the exopolysaccharide produced by Lactobacillus kefiranofaciens on the gut mucosal immunity. Cytokine 36:254–260

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Ahmed Z, Feng W, Li C, Song S (2008) Physicochemical properties of exopolysaccharide produced by Lactobacillus kefiranofaciens ZW3 isolated from Tibet kefir. Int J Biol Macromol 43:283–288

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

Authors are thankful to the Director, CSIR-IICT Hyderabad. Dr. Kezia Devarapalli, Post-doctoral fellow and Ganji Praveena, Senior Research Fellow gratefully acknowledges the UGC, New Delhi, for providing financial support. Chandara Kala Gunturu thankful to the Microl remedies private ltd. The manuscript communication number through CSIR-IICT is IICT/Pubs./2020/061.

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Authors and Affiliations

  1. Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India

    Kezia Devarapalli, Praveena Ganji, Prakasham Reddy Shetty & Linga Banoth

  2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

    Kezia Devarapalli, Praveena Ganji, Prakasham Reddy Shetty & Linga Banoth

  3. Microl Remedies Private Ltd., Hyderabad, Telangana, India

    Chandrakala Gunturu

Authors
  1. Kezia Devarapalli
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  2. Praveena Ganji
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  3. Chandrakala Gunturu
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  4. Prakasham Reddy Shetty
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  5. Linga Banoth
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Corresponding author

Correspondence to Linga Banoth .

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Editors and Affiliations

  1. University Institute of Pharmaceutical Sciences, Chandigarh, Punjab, India

    Sandip V. Pawar

  2. Department of Microbiology, Panjab University, Chandigarh, Punjab, India

    Praveen Rishi

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Devarapalli, K., Ganji, P., Gunturu, C., Reddy Shetty, P., Banoth, L. (2021). Probiotic Based Interventions for Improving Intestinal Health. In: Pawar, S.V., Rishi, P. (eds) Probiotic Research in Therapeutics. Springer, Singapore. https://doi.org/10.1007/978-981-33-6236-9_2

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