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Aptamers for the Diagnosis of Malign Tumors

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Aptamers for Medical Applications

Abstract

Malign tumor is one of the leading causes of human death worldwide, and its incidence increased rapidly year by year. Thus, it is of great importance to improve the strategy of early diagnosis for malign tumors. Aptamers are single-stranded oligonucleotide ligands with excellent chemical properties such as high affinity, easy synthesis, controllable chemical modifications, low immunogenicity, high stability, and fast tissue penetration. Therefore, aptamers are regarded as chemical antibodies and exhibit untapped potential for clinical applications. In this chapter, we highlight the advantages and properties of aptamer-based methods for cancer diagnosis, including cancer biomarker discovery, biosensing, and tumor imaging. We focus on describing several analyses approaches for protein biomarkers, circulating tumor cells, and cancer-related exosomes. The recent imaging techniques for tumor visual measurement are briefly expounded. Furthermore, the challenges and perspectives for the clinical application of aptamer-based methods are discussed.

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Authors and Affiliations

  1. School of Life Sciences, Zhengzhou University, 100# Science Avenue, Zhengzhou, 450001, People’s Republic of China

    Qiyan Lv, Huifang Cui & Xiaojie Song

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  1. Qiyan Lv
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  2. Huifang Cui
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  1. Beijing University of Chemical Technology, Beijing, China

    Yiyang Dong

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Lv, Q., Cui, H., Song, X. (2021). Aptamers for the Diagnosis of Malign Tumors. In: Dong, Y. (eds) Aptamers for Medical Applications. Springer, Singapore. https://doi.org/10.1007/978-981-33-4838-7_9

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