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Hydrogels for Stem Cell Fate Control and Delivery in Regenerative Medicine

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Book cover In-Situ Gelling Polymers

Part of the book series: Series in BioEngineering ((SERBIOENG))

Abstract

The dynamic tissue environment presents spatial and temporal heterogeneity in the cellular and matrix composition. Oxidative stress and inflammation affect the mobilization of stem cells from the stem cell niche, survival and engraftment of exogenous stem cells, and are therefore important considerations when delivering cells in injectable hydrogels to the site of tissue injury. Strategies of anti-inflammation and/or anti-oxidative injury may be incorporated into multifunctional hydrogels to modify the tissue environment and help in the survival/engraftment of the transplanted cells. This could improve the outcome of the regenerative therapy by combined approaches utilizing hydrogels, microtechnologies and controlled release strategies. These advances in hydrogel design and related enabling technologies will continue to grow and aid in our future design of customized hydrogel delivery systems for healthy and injured/diseased tissues, and guide the development of future therapies.

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Acknowledgement

This work was supported by National University of Singapore, National University Healthcare System, Ministry of Education and A*STAR SERC Personal Care IAF.

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Authors and Affiliations

  1. Faculty of Dentistry, National University of Singapore, 11 Lower Kent Ridge Road, Singapore, 119083, Singapore

    Wei Seong Toh

  2. Tissue Engineering Program, Life Sciences Institute National University of Singapore, 27 Medical Drive, Singapore, 117510, Singapore

    Wei Seong Toh

  3. Department of Biomedical Engineering, National University of Singapore, Singapore, 119083, Singapore

    Yi-Chin Toh

  4. Institute of Materials Research and Engineering (IMRE), A*STAR, 3 Research Link, Singapore, 117602, Singapore

    Xian Jun Loh

  5. Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117576, Singapore

    Xian Jun Loh

  6. Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore, 168751, Singapore

    Xian Jun Loh

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    Xian Jun Loh

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Toh, W.S., Toh, YC., Loh, X.J. (2015). Hydrogels for Stem Cell Fate Control and Delivery in Regenerative Medicine. In: Loh, X. (eds) In-Situ Gelling Polymers. Series in BioEngineering. Springer, Singapore. https://doi.org/10.1007/978-981-287-152-7_8

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