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Approaches to Drug Discovery Against Ascariasis: Opportunity and Challenges in Plant-Based Products

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Natural Product Based Drug Discovery Against Human Parasites

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Abstract

Current treatment for effective control of ascariasis largely relies on mass use of anthelmintics. Nonetheless, Ascaris lumbricoides infection still is a major burden of parasitic diseases, especially in areas with poor sanitation and hygiene. Despite the concerns regarding onset of parasitic genotype resistance to drugs, reduction in drug efficacy, side effects, and cost-effectiveness, there has been slow progress in new drug discovery or no new drug development in pipeline against ascariasis. In this report, we highlighted avenues for soil-transmitted helminthes (STHs) drug candidates based on natural plant products. We give an overview and discussed on the plant-derived compounds having anthelmintic activity and its therapeutic potential. We reviewed some of the opportunities and challenges in the approaches to plant-based drug discovery against ascariasis.

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Authors and Affiliations

  1. Zoology Department, Hansraj College, University of Delhi, Delhi, India

    Haorei Yarreiphang

  2. Zoology Department, Deshbandhu College, University of Delhi, Delhi, India

    Irengbam Rocky Mangangcha & Moses Rinchui Ngasainao

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  1. Haorei Yarreiphang
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  2. Irengbam Rocky Mangangcha
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  3. Moses Rinchui Ngasainao
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Corresponding author

Correspondence to Moses Rinchui Ngasainao .

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Editors and Affiliations

  1. Department of Plant Molecular Biology & Delhi School of Climate Change, University of Delhi (South Campus), New Delhi, Delhi, India

    Archana Singh

  2. Department of Chemistry & Delhi School of Public Health, Hansraj College, University of Delhi, Delhi, India

    Brijesh Rathi

  3. Department of Zoology & Delhi School of Public Health, Kirorimal College, University of Delhi, Delhi, India

    Anita K. Verma

  4. Molecular Biology Research Laboratory, Department of Zoology & Delhi School of Public Health, Deshbandhu College, University of Delhi, New Delhi, Delhi, India

    Indrakant K. Singh

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Yarreiphang, H., Mangangcha, I.R., Ngasainao, M.R. (2023). Approaches to Drug Discovery Against Ascariasis: Opportunity and Challenges in Plant-Based Products. In: Singh, A., Rathi, B., Verma, A.K., Singh, I.K. (eds) Natural Product Based Drug Discovery Against Human Parasites. Springer, Singapore. https://doi.org/10.1007/978-981-19-9605-4_23

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