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Lactic Acid Production from Fungal Machineries and Mechanism of PLA Synthesis: Application of AI-Based Technology for Improved Productivity

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Fungi and Fungal Products in Human Welfare and Biotechnology

Abstract

Lactic acid production and its polymerization to poly-lactide (PLA) using renewable resources have recently gained advancement in the field of biomedical science. It is greeted as a promising alternative to tackle the alarmingly environmental, economical and technological issues raised from excessive use of petroleum-based plastics. PLA due to its good processability and biocompatibility always has fascinated researchers in the clinical sector, yet its high degree of hydrophobicity and absence of reactive groups cause steric hindrance and impeded biofunctionalization of PLA surface for cell attachment. PLA production from renewable resources showed a significant reduction in greenhouse gas emissions and fossil energy use as compared to conventional petrochemical-based polymers, thus reducing the threat of global warming. Although lactic acid production from lactic acid bacteria (LAB) is an illustrious domain, production of the green chemical using fungal biomachineries is yet a domain to be explored. Artificial intelligence (AI), a high-tech next-generation technology, is being adapted in all research fields starting from big data analysis to personalized medicines. AI-based mycology modelling for lactic acid production unlocks new prospects for the researcher. The present article is an attempt to explain the potentials of lactic acid production using fungal machineries for sustainable development.

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Authors and Affiliations

  1. Microbial Biotechnology and Downstream Processing Laboratory, Agricultural and Food Engineering Department, Indian Institute of Technology Kharagpur, Kharagpur, India

    Mohan Das, Sayantan Santra,  Rajlakshmi, Sarveshwaran Saravanabhupathy & Rintu Banerjee

  2. P.K. Sinha Centre for Bioenergy and Renewables, Indian Institute of Technology Kharagpur, Kharagpur, India

    Subhara Dey & Rintu Banerjee

  3. Advanced Technology Development Centre, Indian Institute of Technology Kharagpur, Kharagpur, India

    Subhodeep Banerjee & Rintu Banerjee

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  1. Division of Biological Science & Engineering, Netaji Subhas University of Technology, New Delhi, Delhi, India

    Tulasi Satyanarayana

  2. R & D Division, Greenvention Biotech Pvt. Ltd., Uruli-Kanchan, Pune, Maharashtra, India

    Sunil Kumar Deshmukh

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Das, M. et al. (2023). Lactic Acid Production from Fungal Machineries and Mechanism of PLA Synthesis: Application of AI-Based Technology for Improved Productivity. In: Satyanarayana, T., Deshmukh, S.K. (eds) Fungi and Fungal Products in Human Welfare and Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-19-8853-0_8

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