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A Bird’s-Eye View of Fungal Peptides

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Fungi and Fungal Products in Human Welfare and Biotechnology

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Abstract

Peptide-based drugs/antibiotics are increasingly becoming preferable due to greater incidence of multidrug resistance towards non-peptidic drugs. In addition, several non-peptidic compounds also elicit unfavorable or toxic side effects. Consequently, besides bacteria, plants and animal-based sources, fungi have also been explored very much in the search for novel therapeutic peptides that can be more efficacious and safer. Based on the biosynthetic pathways, these peptides can be classified as (i) ribosomal peptides and (ii) non-ribosomal peptides (NRPs). Several NRPs from diverse fungal sources (soil, marine, and endophytes) have been identified and comprehensively characterized, whereas studies on ribosomal peptides of fungal origin are limited. In terms of molecular architecture, fungal peptides can be classified into four major categories: (i) linear peptides with modified N- and C-termini (e.g., peptaibiotics and peptaibols); (ii) head-to-tail (backbone) cyclized peptides; (iii) cyclic depsipeptides; and (iv) sidechain cyclized peptides. In this chapter, salient features of some major fungal peptides that have been found to elicit various kinds of biological activities are presented. A few aspects on some fungal peptide-based products of pharmaceutical or medical relevance, e.g., caspofungin (brand name: Cancidas) and cyclosporin A, which are already available in the market, are also briefly delineated.

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  1. Centre for Bio-Separation Technology (CBST), Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, India

    V. Sabareesh

  2. PG & Research Department of Chemistry, Auxilium College (Autonomous), Vellore, Tamil Nadu, India

    V. S. Gowri

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    Tulasi Satyanarayana

  2. R & D Division, Greenvention Biotech Pvt. Ltd., Uruli-Kanchan, Pune, Maharashtra, India

    Sunil Kumar Deshmukh

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Sabareesh, V., Gowri, V.S. (2023). A Bird’s-Eye View of Fungal Peptides. In: Satyanarayana, T., Deshmukh, S.K. (eds) Fungi and Fungal Products in Human Welfare and Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-19-8853-0_6

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