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Crassocephalum crepidioides (Benth.) S. Moore: Traditional Uses, Chemical Constituents, and Biological Activities

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Medicinal Plants of the Asteraceae Family

Abstract

Medicinal plants belonging to the Asteraceae family are reported to have long history in traditional medicines which are widely distributed throughout the world in several ecological habitats. The genus Crassocephalum consists of 24 accepted species in which species C. crepidioides is one of them. It is commonly known as “fireweed ragleaf” in English and “Anikale jhar” in Nepali. There are several traditional uses associated with the plant which have been proven by several scientific studies. C. crepidioides is consumed as leafy vegetables in Africa. Several pharmacological activities including antibacterial, wound healing, antidiabetic, anti-inflammatory, and antioxidant properties are reported in the plant. Secondary metabolites such as alkaloids, flavonoids, and phenolic compounds are the main constituents present in C. crepidioides. In this chapter, the traditional uses, pharmacological activities, and phytochemical constituents of C. crepidioides are presented along with the safety and toxicity profile.

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References

  • Adefegha SA, Oboh G, Molehin OR, Saliu JA, Athayde ML, Boligon AA (2014) Chromatographic fingerprint analysis, acetylcholinesterase inhibitory properties and antioxidant activities of Redflower ragleaf (Crassocephalum crepidioides) extract. J Food Biochem 40:109–119. https://doi.org/10.1111/jfbc.12200

    Article  CAS  Google Scholar 

  • Adjatin A, Dansi A, Eze CS, Assogba P, Dossou-Aminon I, Akpagana K, Akoegninou A, Sanni A (2012) Ethnobotanical investigation and diversity of Gbolo (Crassocephalum rubens (Juss. Ex Jacq.) S. Moore and Crassocephalum crepidioides (Benth.) S. Moore), a traditional leafy vegetable under domestication in Benin. Genet Resour Crop Evol 59(8):1867–1881

    Article  Google Scholar 

  • Aniya Y, Koyama T, Miyagi C, Miyahira M, Inomata C, Kinoshita S, Ichiba T (2005) Free radical scavenging and Hepatoprotective actions of the medicinal herb, Crassocephalum crepidioides from the Okinawa Islands. Biol Pharm Bull 28(1):19–23. https://pubmed.ncbi.nlm.nih.gov/15635156/

    Article  CAS  Google Scholar 

  • Ayodele OO, Onajobi FD, Osoniyi O (2019) In vitro anticoagulant effect of Crassocephalum crepidioides leaf methanol extract and fractions on human blood. J Exp Pharmacol 11:99–107. https://doi.org/10.2147/JEP.S218261

    Article  CAS  Google Scholar 

  • Ayodele OO, Onajobi FD, Osoniyi OR (2020a) Chemical profiling of the hexane fraction of Crassocephalum crepidioides Benth S. Moore leaves by GC-MS. Afr J Pure Appl Chem 14(1):1–8. https://doi.org/10.5897/AJPAC2019.0815

    Article  CAS  Google Scholar 

  • Ayodele O, Osonlyl RO, Onajobi FD (2020b) Phytochemical profiling of the hexane fraction of Crassocephalum crepidioides Benth S. Moore leaves by GC-MS. Afr J Pure Appl Chem 14(1):1–8. https://www.researchgate.net/publication/340310897

    Article  CAS  Google Scholar 

  • Bahar E, Akter KM, Lee GH, Lee HY, Rashid HO, Choi MK, Bhattarai KR, Hossain MMM, Ara J, Mazumder K, Raihan O, Chae HJ, Yoon H (2017) β-Cell protection and antidiabetic activities of Crassocephalum crepidioides (Asteraceae) Benth. S. Moore extract against alloxan-induced oxidative stress via regulation of apoptosis and reactive oxygen species (ROS). BMC Complement Altern Med 17:179. https://doi.org/10.1186/s12906-017-1697-0

    Article  CAS  Google Scholar 

  • Can NM, Thao DTP (2020) Wound healing activity of Crassocephalum crepidioides (Benth.) S. Moore. Leaf hydroethanolic extract. Oxid Med Cell Longev 2020:2483187. https://doi.org/10.1155/2020/2483187

    Article  CAS  Google Scholar 

  • Dansi A, Adjatin A, Badoussi E, Loko YL, Dansi M, Gbaguidi F, Ajokpota P, Ahissou H, Akoegninou A, Akpagana K, Sanni A (2013) Phytochemical screening and toxicity studies of Crassocephalum rubens (Juss. Ex Jacq.) S. Moore and Crassocephalum crepidioides (Benth.) S. Moore consumed as vegetable in Benin. J Chem Pharm Res 5(6):160–167

    Google Scholar 

  • Hung NH, Satyal P, Dai DN, Tai TA, Huong LT, Hong Chuong NT, Hieu HV, Tuan PA, Vuong PV, Setzer WN (2019) Chemical compositions of Crassocephalum crepidioides essential oils and larvicidal activities against Aedes aegypti, Aedes albopictus, and Culex quinquefasciatus. Nat Prod Commun 14(6):1–5. https://doi.org/10.1177/1934578X19850033

    Article  Google Scholar 

  • Joshi RK (2014) Study of essential oil composition of the roots of Crassocephalum crepidioides (Benth.) S. Moore. J Chil Chem Soc 59:1. https://doi.org/10.4067/S0717-97072014000100025

    Article  Google Scholar 

  • Manandhar NP (2002) Plants and people of Nepal. Timber Press, Inc., Portland

    Google Scholar 

  • Nguemfo EL, Mbock AJ, Zangueu Bogning C, Magne Fongang AL, Belle Ebanda Kedi P, Dongmo AB (2020) Acute and sub-acute toxicity assessment of aqueous leaves extract of Crassocephalum crepidioides (Asteraceae) in Wister rats. J Complement Integr Med 18(2):295–302. https://doi.org/10.1515/jcim-2020-0018

    Article  CAS  Google Scholar 

  • Owokotomo IA, Ekundayo O, Abayomi TG, Chukwuka AV (2015) In-vitro anti-cholinesterase activity of essential oil from four tropical medicinal plants. Toxicol Rep 2:850–857. https://pubmed.ncbi.nlm.nih.gov/28962420/

    Article  CAS  Google Scholar 

  • Schramm S, Rozhon W, Adedeji-Badmus AN, Liang Y, Nayem S, Winkelmann T, Poppenberger B (2021) The orphan crop Crassocephalum crepidioides accumulates the pyrrolizidine alkaloid jacobine in response to nitrogen starvation. Frontiers. Plant Sci 12:702985. https://doi.org/10.3389/fpls.2021.702985

    Article  Google Scholar 

  • Tomimori K, Nakama S, Kimura R, Tamaki K, Ishikawa C, Mori N (2012) Antitumor activity and macrophage nitric oxide producing action of medicinal herb Crassocephalum crepidioides. BMC Complement Altern Med 12:78. https://doi.org/10.1186/1472-6882-12-78

    Article  Google Scholar 

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Correspondence to Prakash Poudel .

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Gurung, S., Poudel, P., Adhikari, N., Lamichhane, G., Thapa, R. (2022). Crassocephalum crepidioides (Benth.) S. Moore: Traditional Uses, Chemical Constituents, and Biological Activities. In: Devkota, H.P., Aftab, T. (eds) Medicinal Plants of the Asteraceae Family. Springer, Singapore. https://doi.org/10.1007/978-981-19-6080-2_9

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