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Dermatological Sequelae of COVID-19 Infection

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Post COVID-19 Complications and Management

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Abstract

Various mucocutaneous manifestations of COVID-19 infection have been recorded in the literature. They may precede, coexist with, or follow the other symptoms of COVID-19 infection. Cutaneous manifestations may be the only manifestation of COVID-19 infection in up to a fifth of patients. Certain cutaneous findings may have a prognostic significance, such as pernio, which typically occurs in mild or asymptomatic disease, and retiform purpura, which may signal a more severe disease. This chapter covers the dermatological manifestations of COVID-19 infection per se, as well as those as a consequence of COVID-19 vaccination, treatment, and use of personal protective equipment (PPE).

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References

  1. Visconti A, Bataille V, Rossi N, Kluk J, Murphy R, Puig S, et al. Diagnostic value of cutaneous manifestation of SARS-CoV-2 infection. Br J Dermatol. 2021;184:880–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Rerknimitr P, Theerawattanawit C, Lertpichitkul P, Jan-Tarabenjakul W, Putcharoen O, Puthanakit T, et al. Skin manifestations in COVID-19: the tropics experience. J Dermatol. 2020;47:444–6.

    Article  Google Scholar 

  3. Matar S, Oulès B, Sohier P, Chosidow O, Beylot-Barroy M, Dupin N, et al. Cutaneous manifestations in SARS-CoV-2 infection (COVID-19): a French experience and a systematic review of the literature. J Eur Acad Dermatol Venereol. 2020;34:686–9.

    Article  Google Scholar 

  4. Solak EO, Ketencioglu BB, Aslaner H, Cinar SL, Kartal D, Benli AR, et al. Cutaneous symptoms of patients diagnosed with COVID-19 in one province: a cross-sectional survey. J Eur Acad Dermatol Venereol. 2021;35:105–6.

    Google Scholar 

  5. Tammaro A, Adebanjo GAR, Parisella FR, Pezzuto A, Rello J. Cutaneous manifestations in COVID-19: the experiences of Barcelona and Rome. J Eur Acad Dermatol Venereol. 2020;34:306–7.

    Article  Google Scholar 

  6. Tamai M, Maekawa A, Goto N, Ge L, Nishida T, Iwahashi H, et al. Three cases of COVID-19 patients presenting with erythema. J Dermatol. 2020;47:1175–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Pangti R, Gupta S, Nischal N, Trikha A. Recognizable vascular skin manifestations of SARS-CoV-2 (COVID-19) infection are uncommon in patients with darker skin phototypes. Clin Exp Dermatol. 2021;46:180–2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Fernandez-Nieto D, Ortega-Quijano D, Suarez-Valle A, Jimenez-Cauhe J, Jaen-Olasolo P, Fernandez-Guarino M. Lack of skin manifestations in COVID-19 hospitalized patients during the second epidemic wave in Spain: a possible association with a novel SARS-CoV-2 variant—a cross-sectional study. J Eur Acad Dermatol Venereol. 2021;35:e183–5.

    Article  CAS  PubMed  Google Scholar 

  9. Sardana K, Sinha S, Yadav A, Deepak D, Panesar S, Mathachan SR. Paucity of cutaneous manifestations of COVID-19 among inpatients in a referral hospital in India. JAAD Int. 2022;8:10–5. https://doi.org/10.1016/j.jdin.2022.01.001.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Khurana A, Mittal A, Jain R, Mishra A, Mathachan SR. Rarity of cutaneous findings among asymptomatic to mildly symptomatic patients with COVID-19 admitted to a COVID care facility in Delhi, India: an observational study. Br J Dermatol. 2021;185:666–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Jamshidi P, Hajikhani B, Mirsaeidi M, Vahidnezhad H, Dadashi M, Nasiri MJ. Skin manifestations in COVID-19 patients: are they indicators for disease severity? A systematic review. Front Med (Lausanne). 2021;8:634208.

    Article  Google Scholar 

  12. Gisondi P, Leo SD, Bellinato F, Cazzaniga S, Piaserico S, Naldi L. Time of onset of selected skin lesions associated with COVID-19: a systematic review. Dermatol Ther (Heidelb). 2021;11:695–705.

    Article  Google Scholar 

  13. Unterluggauer L, Pospischil I, Krall C, et al. Cutaneous manifestations of SARS-CoV-2: a 2-center, prospective, case-controlled study. J Am Acad Dermatol. 2021;85(1):202–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Ng SM. Prolonged dermatological manifestation 4 weeks following recovery of COVID-19 in a child. BMJ Case Rep. 2020;13:e237056.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Bourgonje AR, Abdulle AE, Timens W, Hillebrands JL, Navis GJ, Gordijn SJ, et al. Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19). J Pathol. 2020;251:228–48.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Suchonwanit P, Leerunyakul K, Kositkuljorn C. Cutaneous manifestations in COVID-19: lessons learned from current evidence. J Am Acad Dermatol. 2020;83:57–60.

    Article  Google Scholar 

  17. Jamiolkowski D, Mühleisen B, Müller S, Navarini AA, Tzankov A, Roider E. SARS-CoV-2 PCR testing of skin for COVID-19 diagnostics: a case report. Lancet. 2020;396:598–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Colmenero I, Santonja C, Alonso-Riaño M, Noguera-Morel L, Hernández-Martín A, Andina D, et al. SARS-CoV-2 endothelial infection causes COVID-19 chilblains: histopathological, immunohistochemical and ultrastructural study of seven paediatric cases. Br J Dermatol. 2020;183:729–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Seque CA, Enokihara MMSES, Porro AM, Tomimori J. Skin manifestations associated with COVID-19. An Bras Dermatol. 2022;97(1):75–88.

    Article  PubMed  Google Scholar 

  20. Keshavarz P, Yazdanpanah F, Azhdari S, Kavandi H, Nikeghbal P, Bazyar A, Rafiee F, Nejati SF, Sadabad FE, Rezaei N. Coronavirus disease 2019 (COVID-19): a systematic review of 133 children that presented with Kawasaki-like multisystem inflammatory syndrome. J Med Virol. 2021;93:5458–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Esmaeilzadeh H, Mortazavi N, Salehi A, Fatemian H, Dehghani SM, Vali M, Vardanjani HM. Effect of COVID-19 on Kawasaki disease: decrease age of onset and increase skin manifestation. BMC Pediatr. 2021;21:571.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Freeman EE, McMahon DE, Lipoff JB, Rosenbach M, Kovarik C, Desai SR, Harp J, Takeshita J, French LE, Lim HW, Thiers BH, Hruza GJ, Fox LP. The spectrum of COVID-19-associated dermatologic manifestations: an international registry of 716 patients from 31 countries. J Am Acad Dermatol. 2020;83:1118–29.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Nuno-Gonzalez A, Martin-Carrillo P, Magaletsky K, Rios MDM, Mañas CH, Almazan JA, et al. Prevalence of mucocutaneous manifestations in 666 patients with COVID-19 in a field hospital in Spain: oral and palmoplantar findings. Br J Dermatol. 2021;184:184–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Starace M, Iorizzo M, Sechi A, Alessandrini AM, Carpanese M, Bruni F, et al. Trichodynia and telogen effluvium in COVID-19 patients: results of an international expert opinion survey on diagnosis and management. JAAD Int. 2021;5:11–8.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Hussain N, Agarwala P, Iqbal K, Omar HMS, Jangid G, Patel V, et al. A systematic review of acute telogen effluvium, a harrowing post-COVID-19 manifestation. J Med Virol. 2021; https://doi.org/10.1002/jmv.27534.

  26. Abrantes TF, Artounian KA, Falsey R, Simão JCL, Vañó-Galván S, Ferreira SB, Davis TL, Ridenour W, Goren A, Tosti A, Wambier CG. Time of onset and duration of post-COVID-19 acute telogen effluvium. J Am Acad Dermatol. 2021;85:975–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Moreno-Arrones OM, Lobato-Berezo A, Gomez-Zubiaur A. SARS-CoV-2-induced telogen effluvium: a multicentric study. J Eur Acad Dermatol Venereol. 2021;35:e181–3.

    Article  CAS  PubMed  Google Scholar 

  28. Sattur SS, Sattur IS. COVID-19 infection: impact on hair. Indian J Plast Surg. 2021;54:521–6.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Aksoy H, Yıldırım UM, Ergen P, Gürel MS. COVID-19 induced telogen effluvium. Dermatol Ther. 2021;34:e15175.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Thuangtong R, Angkasekwinai N, Leeyaphan C, et al. Patient recovery from COVID-19 infections: follow-up of hair, nail, and cutaneous manifestations. Biomed Res Int. 2021;2021:5595016.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Preda-Naumescu A, Penney K, Pearlman RL, Brodell RT, Daniel CR, Nahar VK. Nail manifestations in COVID-19: insight into a systemic viral disease. Skin Appendage Disord. 2021;183:1–6.

    PubMed  Google Scholar 

  32. Hadeler E, Morrison BW, Tosti A. A review of nail findings associated with COVID-19 infection. J Eur Acad Dermatol Venereol. 2021;35:e699–709.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Neri I, Guglielmo A, Virdi A, Gaspari V, Starace M, Piraccini BM. The red half-moon nail sign: a novel manifestation of coronavirus infection. J Eur Acad Dermatol Venereol. 2020;34:e663–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Martinez-Lopez A, Cuenca-Barrales C, Montero-Vilchez T, Molina-Leyva A, Arias-Santiago S. Review of adverse cutaneous reactions of pharmacologic interventions for COVID-19: a guide for the dermatologist. J Am Acad Dermatol. 2020;83:1738–48.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Mohseni Afshar Z, Babazadeh A, Hasanpour A, Barary M, Sayad B, Janbakhsh A, Aryanian Z, Ebrahimpour S. Dermatological manifestations associated with COVID-19: a comprehensive review of the current knowledge. J Med Virol. 2021;93:5756–67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Jose S, Cyriac MC, Dhandapani M. Health problems and skin damages caused by personal protective equipment: experience of frontline nurses caring for critical COVID-19 patients in intensive care units. Indian J Crit Care Med. 2021;25:134–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Etgu F, Onder S. Skin problems related to personal protective equipment among healthcare workers during the COVID-19 pandemic (online research). Cutan Ocul Toxicol. 2021;40:207–13.

    Article  CAS  PubMed  Google Scholar 

  38. Teo WL. Diagnostic and management considerations for “maskne” in the era of COVID-19. J Am Acad Dermatol. 2021;84:520–1.

    Article  CAS  PubMed  Google Scholar 

  39. Kaul S, Kaur I, Jakhar D. Facial mask-related acne and acneiform eruption during the coronavirus disease 2019 pandemic: a case series. J Clin Aesthet Dermatol. 2021;14:32–4.

    PubMed  PubMed Central  Google Scholar 

  40. Chiriac AE, Chiriac A, Wollina U. Chloronychia in healthcare workers in COVID-19 times. Skin Appendage Disord. 2021;7:80–1.

    Article  PubMed  Google Scholar 

  41. Rivers JK, Arlette JP, DeKoven J, Guenther LC, Muhn C, Richer V, Rosen N, Tremblay JF, Wiseman MC, Zip C, Zloty D. Skin care and hygiene among healthcare professionals during and after the SARS-CoV-2 pandemic. SAGE Open Med. 2021;8(9):20503121211062795. https://doi.org/10.1177/20503121211062795.

    Article  Google Scholar 

  42. Sun Q, Fathy R, McMahon DE, Freeman EE. COVID-19 vaccines and the skin: the landscape of cutaneous vaccine reactions worldwide. Dermatol Clin. 2021;39:653–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Zare H, Rezapour H, Mahmoodzadeh S, Fereidouni M. Prevalence of COVID-19 vaccines (Sputnik V, AZD-1222, and Covaxin) side effects among healthcare workers in Birjand city. Iran Int Immunopharmacol. 2021;101:108351.

    Article  CAS  PubMed  Google Scholar 

  44. Diab R, Araghi F, Gheisari M, Kani ZA, Moravvej H. Lichen planus and lichen planopilaris flare after COVID-19 vaccination. Dermatol Ther. 2021;24:e15283. https://doi.org/10.1111/dth.15283.

    Article  CAS  Google Scholar 

  45. Scollan ME, Breneman A, Kinariwalla N, Soliman Y, Youssef S, Bordone LA, Gallitano SM. Alopecia areata after SARS-CoV-2 vaccination. JAAD Case Rep. 2022;20:1–5.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology and Venereology, AIIMS, New Delhi, India

    Pankhuri Dudani, Vishal Gupta & Kaushal K. Verma

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  1. Pankhuri Dudani
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  2. Vishal Gupta
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Editors and Affiliations

  1. Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India

    Anant Mohan

  2. Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India

    Saurabh Mittal

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Dudani, P., Gupta, V., Verma, K.K. (2022). Dermatological Sequelae of COVID-19 Infection. In: Mohan, A., Mittal, S. (eds) Post COVID-19 Complications and Management. Springer, Singapore. https://doi.org/10.1007/978-981-19-4407-9_12

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  • DOI: https://doi.org/10.1007/978-981-19-4407-9_12

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  • Online ISBN: 978-981-19-4407-9

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